Factors affecting consumers' adherence to gluten-free diet, a systematic review

Abstract Background The gluten-free market is expanding rapidly. The reasons for this reflect a growing interest in adopting a gluten-free diet (GFD). This is partly explained by an increasing number of people diagnosed with Celiac Disease (CD), but also because of public perceptions that a GFD is a healthy diet option. However, products specifically marketed as gluten-free (GF) are reduced in several sensorial characteristics, are more expensive, and have lower nutritional values than comparable alternatives. Scope and approach The aim of this review is to provide an up-to-date set of factors that underpin consumers' preferences and adherence to GFD. After screening, 54 articles were considered for the review. Key findings and conclusions The review classifies the factors affecting GFD in eight groups: “Factors specific to the GFD”; “Socio-demographic factors”; “GF products' factors”; “Psychological Factors”; “Symptoms related to Celiac”; “Celiac Disease's factors”; “Quality of Life”; “Other Factors”. Results on the level of association and significance of the factors affecting adherence to GFD are mixed. Moreover, in the process of reviewing the literature, this review reveals that most of the studies that have investigated factors associated with adherence to GFD are focused primarily on celiac patients while neglecting the fact that many non-celiac adopt the diet. From this we discuss future research directions, and what questions remain unanswered in the domain of adherence to the GFD.

[1]  G. Fiates,et al.  Gluten-free is not enough – perception and suggestions of celiac consumers , 2014, International journal of food sciences and nutrition.

[2]  C. Isonne,et al.  Impact of gluten-free diet on quality of life in celiac patients. , 2016, Acta gastro-enterologica Belgica.

[3]  L. Verrill,et al.  Food label usage and reported difficulty with following a gluten-free diet among individuals in the USA with coeliac disease and those with noncoeliac gluten sensitivity. , 2013, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[4]  D. Sanders,et al.  Quality of life in Coeliac Disease is determined by perceived degree of difficulty adhering to a gluten-free diet, not the level of dietary adherence ultimately achieved. , 2011, Journal of gastrointestinal and liver diseases : JGLD.

[5]  A. Cano Ruiz,et al.  [Non-celiac gluten sensitivity: a true entity or just a chimera?]. , 2014, Medicina clinica.

[6]  P. Green,et al.  Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder , 2005, Annals of Internal Medicine.

[7]  G. Bacigalupe,et al.  Celiac is a social disease: family challenges and strategies. , 2015, Families, systems & health : the journal of collaborative family healthcare.

[8]  D. Leffler,et al.  Body mass index and the risk of obesity in coeliac disease treated with the gluten‐free diet , 2012, Alimentary pharmacology & therapeutics.

[9]  K. Whelan,et al.  Limited availability and higher cost of gluten-free foods. , 2011, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[10]  Magdalena Ferster,et al.  Trudności związane z przestrzeganiem diety bezglutenowej przez chorych na celiakię mieszkających na Górnym Śląsku , 2015 .

[11]  T. de-Magistris,et al.  The Role of Taste and Label Information on Purchase Decision: Assessment of a Gluten-Free Wafer by Non-Celiac Consumers , 2015 .

[12]  M. Mearin,et al.  Dietary compliance and health-related quality of life in patients with coeliac disease , 2009, European journal of gastroenterology & hepatology.

[13]  D. Franko,et al.  Psychological Correlates of Gluten-free Diet Adherence in Adults With Celiac Disease , 2009, Journal of clinical gastroenterology.

[14]  M. Zarkadas,et al.  Living with coeliac disease and a gluten-free diet: a Canadian perspective. , 2013, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[15]  G. Makharia,et al.  Adherence to gluten-free diet and barriers to adherence in patients with celiac disease , 2015, Indian Journal of Gastroenterology.

[16]  E. Cook,et al.  A simple validated gluten-free diet adherence survey for adults with celiac disease. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[17]  H. Rammensee,et al.  Neurological symptoms in patients with biopsy proven celiac disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[18]  Suzanne K. Lewis,et al.  Is Dietitian Use Associated with Celiac Disease Outcomes? , 2013, Nutrients.

[19]  K. Kaukinen,et al.  Patients' experiences and perceptions of living with coeliac disease - implications for optimizing care. , 2012, Journal of gastrointestinal and liver diseases : JGLD.

[20]  C. Cellier,et al.  [CELIAC DISEASE]. , 2015, La Revue du praticien.

[21]  N. Afzal,et al.  Parental knowledge of coeliac disease , 2015, Informatics for health & social care.

[22]  M. Beauchamp,et al.  Motives for adherence to a gluten-free diet: a qualitative investigation involving adults with coeliac disease. , 2014, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[23]  A. Ivarsson,et al.  Seeking a new normality : masculinity, interaction and a gluten free diet , 2016 .

[24]  K. Kaukinen,et al.  Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional study , 2013, BMC Gastroenterology.

[25]  E. Arendt,et al.  Gluten-free cereal products and beverages , 2008 .

[26]  A. Ivarsson,et al.  Living with Celiac Disease: Norms of Femininity and the Complications of Everyday Life , 2017 .

[27]  P. Gibson,et al.  Characterization of Adults With a Self-Diagnosis of Nonceliac Gluten Sensitivity. , 2014, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[28]  D. Schuppan,et al.  Factors that Influence Adherence to a Gluten-Free Diet in Adults with Celiac Disease , 2008, Digestive Diseases and Sciences.

[29]  B. Mullan,et al.  Dissemination of an Online Theory-Based Intervention to Improve Gluten-Free Diet Adherence in Coeliac Disease: the Relationship Between Acceptability, Effectiveness, and Attrition , 2015, International Journal of Behavioral Medicine.

[30]  A. Lucendo,et al.  Benefit on health-related quality of life of adherence to gluten-free diet in adult patients with celiac disease. , 2015, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[31]  E. Giltay,et al.  Coeliac disease, diet adherence and depressive symptoms. , 2013, Journal of psychosomatic research.

[32]  D. Schuppan,et al.  Update on Serologic Testing in Celiac Disease , 2010, The American Journal of Gastroenterology.

[33]  D. Sanders,et al.  Factors influencing the type, timing and severity of symptomatic responses to dietary gluten in patients with biopsy-proven coeliac disease. , 2013, Journal of gastrointestinal and liver diseases : JGLD.

[34]  S. Saxena,et al.  The World Health Organization Quality of Life assessment (WHOQOL): position paper from the World Health Organization. , 1995, Social science & medicine.

[35]  L. Graff,et al.  Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods. , 2016, Nutrition.

[36]  F. Casellas,et al.  Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain. , 2016, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[37]  T. D. Magistris,et al.  The effect of sensory properties on non-celiac consumers’ willingness to pay for a gluten-free snack , 2015 .

[38]  V. Polzonetti,et al.  Gluten free diet and nutrient deficiencies: A review. , 2016, Clinical nutrition.

[39]  B. Mullan,et al.  Predicting intention and behaviour following participation in a theory-based intervention to improve gluten free diet adherence in coeliac disease , 2015, Psychology & health.

[40]  K. Kaukinen,et al.  Diet improves perception of health and well-being in symptomatic, but not asymptomatic, patients with celiac disease. , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[41]  R. Howard,et al.  Living with coeliac disease: a grounded theory study. , 2014, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[42]  J. Arěas,et al.  Gluten-free breadmaking: Improving nutritional and bioactive compounds , 2016 .

[43]  K. Kaukinen,et al.  Factors Associated with Dietary Adherence in Celiac Disease: A Nationwide Study , 2012, Digestion.

[44]  Fabio Aiello,et al.  Complications in Celiac Disease Under Gluten-Free Diet , 2009, Digestive Diseases and Sciences.

[45]  Mary M. Niewinski Advances in celiac disease and gluten-free diet. , 2008, Journal of the American Dietetic Association.

[46]  M. Dennis,et al.  Celiac Disease and the Gluten-Free Diet: Consequences and Recommendations for Improvement , 2015, Digestive Diseases.

[47]  Z. Szakály,et al.  The influence of lifestyle on health behavior and preference for functional foods , 2012, Appetite.

[48]  Hsiu-Fen Lin,et al.  Effects of extrinsic and intrinsic motivation on employee knowledge sharing intentions , 2007, J. Inf. Sci..

[49]  G. Makharia,et al.  Problems and Challenges to Adaptation of Gluten Free Diet by Indian Patients with Celiac Disease , 2013, Nutrients.

[50]  L. Graff,et al.  Living gluten-free: adherence, knowledge, lifestyle adaptations and feelings towards a gluten-free diet. , 2016, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[51]  S. Reeves,et al.  Adherence to a Gluten Free Diet Is Associated with Receiving Gluten Free Foods on Prescription and Understanding Food Labelling , 2017, Nutrients.

[52]  B. Mullan,et al.  Reduced quality of life in coeliac disease is more strongly associated with depression than gastrointestinal symptoms. , 2013, Journal of psychosomatic research.

[53]  E. Capristo,et al.  State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting , 2008, International journal of clinical practice.

[54]  P. Howdle,et al.  Evidence of high sugar intake, and low fibre and mineral intake, in the gluten‐free diet , 2010, Alimentary pharmacology & therapeutics.

[55]  C. Corposanto,et al.  Celiac Disease Seen with the Eyes of the Principle Component Analysis and Analyse Des Données , 2015 .

[56]  F. Casellas,et al.  Factors that impact health-related quality of life in adults with celiac disease: a multicenter study. , 2008, World journal of gastroenterology.

[57]  Klaus G. Grunert,et al.  Three issues in consumer quality perception and acceptance of dairy products , 2000 .

[58]  Halina Mayer Chaves Araújo,et al.  Coeliac disease. Following the diet and eating habits of participating individuals in the Federal District, Brazil , 2011, Appetite.

[59]  S. Acaster,et al.  A Novel Patient-Derived Conceptual Model of the Impact of Celiac Disease in Adults: Implications for Patient-Reported Outcome and Health-Related Quality-of-Life Instrument Development. , 2017, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

[60]  H. Ward,et al.  Predictive Validity of a Medication Adherence Measure in an Outpatient Setting , 2008, Journal of clinical hypertension.

[61]  Examining Non‐Celiac Consumers of Gluten‐Free Products: An Empirical Evidence in Spain , 2017 .

[62]  Carolyn Newberry,et al.  Going Gluten Free: the History and Nutritional Implications of Today’s Most Popular Diet , 2017, Current Gastroenterology Reports.

[63]  Farah Naqash,et al.  Gluten-free baking: Combating the challenges - A review , 2017 .

[64]  R. Nisihara,et al.  QUALITY OF LIFE EVALUATION IN CELIAC PATIENTS FROM SOUTHERN BRAZIL. , 2015, Arquivos de gastroenterologia.

[65]  R. Shamir,et al.  Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets. , 2013, World journal of gastroenterology.

[66]  Beat Mollet,et al.  Functional foods: at the frontier between food and pharma. , 2002, Current opinion in biotechnology.

[67]  H. Bolini,et al.  Prebiotic gluten-free bread: Sensory profiling and drivers of liking , 2014 .

[68]  A. Ivarsson,et al.  The everyday life of adolescent coeliacs: issues of importance for compliance with the gluten-free diet. , 2008, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[69]  D. Leffler,et al.  Factors governing long‐term adherence to a gluten‐free diet in adult patients with coeliac disease , 2015, Alimentary pharmacology & therapeutics.

[70]  Pradyuman Kumar,et al.  Gluten free approach in fat and sugar amended biscuits: A healthy concern for obese and diabetic individuals , 2018 .

[71]  P. Gibson,et al.  Randomised clinical trial: gluten may cause depression in subjects with non‐coeliac gluten sensitivity – an exploratory clinical study , 2014, Alimentary pharmacology & therapeutics.

[72]  Susy Rocha,et al.  Os impactos psicossociais gerados pelo diagnóstico e tratamento da doença celíaca , 2016 .

[73]  M. Ferster,et al.  Difficulties related to compliance with gluten-free diet by patients with coeliac disease living in Upper Silesia , 2015 .

[74]  J. Smyth,et al.  Psychiatric comorbidities in women with Celiac Disease , 2012, Chronic illness.

[75]  D. Leffler,et al.  Socioeconomic Risk Factors for Celiac Disease Burden and Symptoms , 2016, Journal of clinical gastroenterology.

[76]  D. Leffler,et al.  Patient Perception of Treatment Burden Is High in Celiac Disease Compared With Other Common Conditions , 2014, The American Journal of Gastroenterology.

[77]  G. Fiates,et al.  Availability, cost and nutritional composition of gluten-free products , 2014 .

[78]  T. Stellingwerff,et al.  Exploring the popularity, experiences, and beliefs surrounding gluten-free diets in nonceliac athletes. , 2015, International journal of sport nutrition and exercise metabolism.

[79]  G. Rubin,et al.  Systematic review: adherence to a gluten‐free diet in adult patients with coeliac disease , 2009, Alimentary pharmacology & therapeutics.

[80]  K. Sainsbury,et al.  The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis , 2018, Appetite.

[81]  Liisa Lähteenmäki,et al.  Reasons behind consumers’ functional food choices , 2003 .

[82]  R. Howard,et al.  Psychosocial aspects of coeliac disease: a cross-sectional survey of a UK population. , 2012, British journal of health psychology.

[83]  A. G. Cruz,et al.  Gluten-free bread: multiple time–intensity analysis, physical characterisation and acceptance test , 2013 .

[84]  J. König,et al.  Gluten-free food database: the nutritional quality and cost of packaged gluten-free foods , 2015, PeerJ.

[85]  Louise Sharpe,et al.  Gluten free diet adherence in coeliac disease. The role of psychological symptoms in bridging the intention–behaviour gap , 2013, Appetite.

[86]  N. Pellegrini,et al.  Nutritional aspects of gluten-free products. , 2015, Journal of the science of food and agriculture.

[87]  B. Neal,et al.  Are gluten-free foods healthier than non-gluten-free foods? An evaluation of supermarket products in Australia , 2015, British Journal of Nutrition.

[88]  P. Shekelle,et al.  Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation , 2015, BMJ : British Medical Journal.

[89]  Suzanne K. Lewis,et al.  Quality of Life in Screen-detected Celiac Disease Patients in the United States , 2015, Journal of clinical gastroenterology.

[90]  Barbara Mullan,et al.  Measuring beliefs about gluten free diet adherence in adult coeliac disease using the theory of planned behaviour , 2011, Appetite.