Pyridoxamine as inhibitor of the blood plasma benzylamine oxidase and other copper‐containing amine oxidases

Pyridoxamine inhibits rabbit and pig plasma benzylamine oxidase (BAO), the diamine oxidase of pig kidney and the lysyloxidase of pig aorta in‐vitro. In‐vivo in the rabbit, the inhibitory activity of pyridoxamine on plasma BAO is antagonized by an increase in the level of this enzyme that is dependent on an increase in rate of synthesis, there being no variation in the degradation rate constant.

[1]  F. Buffoni,et al.  Active-sitve titration of pig plasma benzylamine oxidase with phenylhydrazine. , 1975, The Biochemical journal.

[2]  M. Beeler,et al.  Standardization of serum ceruloplasmin concentrations in international enzyme units with o-dianisidine dihydrochloride as substrate. , 1974, Clinical chemistry.

[3]  D. W. Smith,et al.  The purification and partial characterization of a soluble elastin-like protein from copper-deficient porcine aorta. , 1969, Biochemistry.

[4]  G. Martin,et al.  The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[5]  H. Blaschko,et al.  Benzylamine oxidase and histaminase: purification and crystallization of an enzyme from pig plasma , 1964, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[6]  H. Wada,et al.  The enzymatic oxidation of pyridoxine and pyridoxamine phosphates. , 1961, The Journal of biological chemistry.

[7]  E. Angelakos,et al.  Histamine toxicity in mice and rats following treatment with histaminase inhibitors. , 1957, The Journal of pharmacology and experimental therapeutics.

[8]  W. J. Waddell,et al.  A simple ultraviolet spectrophotometric method for the determination of protein. , 1956, The Journal of laboratory and clinical medicine.

[9]  C. W. Tabor,et al.  Purification of amine oxidase from beef plasma. , 1954, The Journal of biological chemistry.

[10]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[11]  W. C. Schneider,et al.  INTRACELLULAR DISTRIBUTION OF ENZYMES V. FURTHER STUDIES ON THE DISTRIBUTION OF CYTOCHROME c IN RAT LIVER HOMOGENATES , 1950 .

[12]  F. Buffoni.  Biochemical pharmacology of amine oxidases , 1983 .

[13]  B. N. Bachra,et al.  Simplified assay for lysyl oxidase activity. , 1977, Analytical biochemistry.

[14]  E. Bernt,et al.  UV-Assay, Manual Method , 1974 .