Digging a little deeper: the stages of invadopodium formation and maturation.

[1]  J. Condeelis,et al.  Talin regulates moesin – NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis , 2014 .

[2]  J. Condeelis,et al.  A Trio-Rac1-PAK1 signaling axis drives invadopodia disassembly , 2014, Nature Cell Biology.

[3]  P. Ferguson,et al.  PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS The F-BAR protein PSTPIP 1 controls extracellular matrix degradation and fi lopodia formation in macrophages , 2014 .

[4]  M. McNiven,et al.  Vav1 as a Central Regulator of Invadopodia Assembly , 2014, Current Biology.

[5]  P. Paul-Gilloteaux,et al.  Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia , 2013, The Journal of cell biology.

[6]  S. Weed,et al.  NEDD9 Depletion Leads to MMP14 Inactivation by TIMP2 and Prevents Invasion and Metastasis , 2013, Molecular Cancer Research.

[7]  L. Counillon,et al.  NaV1.5 Na+ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia , 2013, Journal of Cell Science.

[8]  James Lee,et al.  Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells , 2013, Journal of Cell Science.

[9]  J. Condeelis,et al.  Tks5 and SHIP2 Regulate Invadopodium Maturation, but Not Initiation, in Breast Carcinoma Cells , 2013, Current Biology.

[10]  J. Condeelis,et al.  Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation , 2013, Oncogene.

[11]  H. Wiley,et al.  Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo , 2013, Oncogene.

[12]  J. Condeelis,et al.  Functions of cofilin in cell locomotion and invasion , 2013, Nature Reviews Molecular Cell Biology.

[13]  S. Kiriakidis,et al.  Hypoxia-induced invadopodia formation: a role for β-PIX , 2013, Open Biology.

[14]  J. Condeelis,et al.  β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation , 2013, Molecular biology of the cell.

[15]  C. Greer,et al.  Integrin α3 Is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior , 2013, The Journal of Neuroscience.

[16]  S. Higashiyama,et al.  Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia , 2013, The Journal of cell biology.

[17]  M. Charbonneau,et al.  HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion , 2013, PloS one.

[18]  C. Turner,et al.  Beta2-Adaptin Binds Actopaxin and Regulates Cell Spreading, Migration and Matrix Degradation , 2012, PloS one.

[19]  M. Tremblay,et al.  Met receptor tyrosine kinase signals through a cortactin–Gab1 scaffold complex, to mediate invadopodia , 2012, Journal of Cell Science.

[20]  Alissa M. Weaver,et al.  Adhesion rings surround invadopodia and promote maturation , 2012, Biology Open.

[21]  C. Turner,et al.  Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition , 2012, The Journal of cell biology.

[22]  John Condeelis,et al.  Directed cell invasion and migration during metastasis. , 2012, Current opinion in cell biology.

[23]  JaneR . Taylor,et al.  Integrin β1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior , 2012, The Journal of Neuroscience.

[24]  C. Der,et al.  The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector , 2012, Molecular and Cellular Biology.

[25]  M. McNiven,et al.  Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex , 2012, The Journal of cell biology.

[26]  D. Larson,et al.  Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway , 2011, The Journal of cell biology.

[27]  S. Linder,et al.  Degrading devices: invadosomes in proteolytic cell invasion. , 2011, Annual review of cell and developmental biology.

[28]  O. Destaing,et al.  Invadosome regulation by adhesion signaling. , 2011, Current opinion in cell biology.

[29]  S. Courtneidge,et al.  The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function , 2011, Nature Reviews Molecular Cell Biology.

[30]  Z. Kouchi,et al.  Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation , 2011, The Journal of cell biology.

[31]  H. Chander,et al.  Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis , 2011, Journal of Cell Science.

[32]  J. Condeelis,et al.  A Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia , 2011, Current Biology.

[33]  Thinzar M. Lwin,et al.  Twist1-induced invadopodia formation promotes tumor metastasis. , 2011, Cancer cell.

[34]  J. Condeelis,et al.  An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. , 2011, Cancer research.

[35]  Alissa M. Weaver,et al.  Sensing and modulation of invadopodia across a wide range of rigidities. , 2011, Biophysical journal.

[36]  S. Lim,et al.  p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. , 2011, Cancer research.

[37]  D. Bouvard,et al.  β1A Integrin Is a Master Regulator of Invadosome Organization and Function , 2010, Molecular biology of the cell.

[38]  J. Condeelis,et al.  Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia , 2010, Journal of Cell Science.

[39]  A. Paradiso,et al.  NHE1 promotes invadopodial ECM proteolysis through acidification of the peri‐invadopodial space , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  Robert D. Goldman,et al.  Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia , 2010, The Journal of cell biology.

[41]  Q. Feng,et al.  Phosphorylation of the Cool-1/β-Pix Protein Serves as a Regulatory Signal for the Migration and Invasive Activity of Src-transformed Cells* , 2010, The Journal of Biological Chemistry.

[42]  S. Webb,et al.  Focal adhesions are sites of integrin extension , 2010, The Journal of cell biology.

[43]  John C. Dawson,et al.  The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion , 2010, Current Biology.

[44]  A. Koleske,et al.  Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts , 2009, Journal of Cell Science.

[45]  J. Condeelis,et al.  Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation , 2009, The Journal of cell biology.

[46]  R. Grenman,et al.  Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia , 2009, Journal of cellular and molecular medicine.

[47]  S. Lim,et al.  A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells , 2009, Journal of Cell Science.

[48]  J. Condeelis,et al.  N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. , 2009, Cell motility and the cytoskeleton.

[49]  A. Huttenlocher,et al.  FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion , 2009, The Journal of cell biology.

[50]  Guillem Rigaill,et al.  Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. , 2009, Cancer research.

[51]  V. Castronovo,et al.  Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is up-regulated in prostate and breast cancer. , 2009, Cancer research.

[52]  K. Kikuchi,et al.  WAVE2‐ and microtubule‐dependent formation of long protrusions and invasion of cancer cells cultured on three‐dimensional extracellular matrices , 2008, Cancer science.

[53]  D. Bouvard,et al.  Podosome-type adhesions and focal adhesions, so alike yet so different. , 2008, European journal of cell biology.

[54]  Pierre Nassoy,et al.  MT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7 , 2008, Current Biology.

[55]  Jean-Baptiste Sibarita,et al.  The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA , 2008, The Journal of cell biology.

[56]  Mario Gimona,et al.  Assembly and biological role of podosomes and invadopodia. , 2008, Current opinion in cell biology.

[57]  A. Huttenlocher,et al.  Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion , 2008, The Journal of cell biology.

[58]  M. Gardel,et al.  PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility , 2008, The Journal of cell biology.

[59]  Alissa M. Weaver,et al.  Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. , 2007, Cancer research.

[60]  María C Montoya,et al.  MT1‐MMP proinvasive activity is regulated by a novel Rab8‐dependent exocytic pathway , 2007, The EMBO journal.

[61]  J. Settleman,et al.  Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. , 2006, Molecular biology of the cell.

[62]  E. Andrianantoandro,et al.  Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. , 2006, Molecular cell.

[63]  Thomas Walz,et al.  Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. , 2006, Immunity.

[64]  Françoise Seillier-Moiseiwitsch,et al.  Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. , 2006, Cancer research.

[65]  C. Der,et al.  GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors , 2005, Nature Reviews Molecular Cell Biology.

[66]  J. Segall,et al.  Molecular mechanisms of invadopodium formation , 2005, The Journal of cell biology.

[67]  Nicole Rusk,et al.  Role of Synaptojanin 2 in Glioma Cell Migration and Invasion , 2004, Cancer Research.

[68]  M. Humphries,et al.  Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? , 2004, Current opinion in cell biology.

[69]  J. Condeelis,et al.  Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension , 2004, Journal of Cell Science.

[70]  M. Gimona,et al.  Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains , 2004, Journal of Cell Science.

[71]  M. Kogo,et al.  Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells , 2003, Genes to cells : devoted to molecular & cellular mechanisms.

[72]  E. Génot,et al.  Actin Can Reorganize into Podosomes in Aortic Endothelial Cells, a Process Controlled by Cdc42 and RhoA , 2003, Molecular and Cellular Biology.

[73]  H. Itoh,et al.  Src Kinase Regulates the Activation of a Novel FGD-1-related Cdc42 Guanine Nucleotide Exchange Factor in the Signaling Pathway from the Endothelin A Receptor to JNK* , 2003, Journal of Biological Chemistry.

[74]  H. Duewel,et al.  Two Distinct Phosphorylation Pathways Have Additive Effects on Abl Family Kinase Activation , 2003, Molecular and Cellular Biology.

[75]  María Yáñez-Mó,et al.  ECM regulates MT1-MMP localization with β1 or αvβ3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells , 2002, The Journal of cell biology.

[76]  T. Uemura,et al.  Control of Actin Reorganization by Slingshot, a Family of Phosphatases that Dephosphorylate ADF/Cofilin , 2002, Cell.

[77]  Thilo Stehle,et al.  Crystal Structure of the Extracellular Segment of Integrin αVβ3 , 2001, Science.

[78]  S. Narumiya,et al.  Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. , 2001, Molecular biology of the cell.

[79]  D. Barber,et al.  Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. , 2000, Molecular cell.

[80]  Eric S. Lander,et al.  Genomic analysis of metastasis reveals an essential role for RhoC , 2000, Nature.

[81]  S. Akiyama,et al.  A Novel Protease-docking Function of Integrin at Invadopodia* , 1999, The Journal of Biological Chemistry.

[82]  M. Aepfelbacher,et al.  Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[83]  E. Nishida,et al.  Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization , 1998, Nature.

[84]  T. Cruz,et al.  Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts* , 1998, The Journal of Biological Chemistry.

[85]  P. Coopman,et al.  Integrin alpha 3 beta 1 participates in the phagocytosis of extracellular matrix molecules by human breast cancer cells. , 1996, Molecular biology of the cell.

[86]  W. T. Chen,et al.  Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins , 1994, Journal of cellular physiology.

[87]  W. T. Chen,et al.  Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells. , 1989, The Journal of experimental zoology.

[88]  A. Frelinger,et al.  Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. , 1988, The Journal of biological chemistry.

[89]  D. Megías,et al.  Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion. , 2009, Cell motility and the cytoskeleton.

[90]  Antje Gohla,et al.  Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics , 2005, Nature Cell Biology.