Does aluminum exposure of pregnant animals lead to accumulation in mothers or their offspring?

There is concern that environmental and dietary aluminum (Al) might cause developmental toxicity. To better understand this concern, we reviewed published studies which administered Al compounds to pregnant animals and measured accumulation of Al in mother, fetus, or born offspring. A total of 7 studies were identified which administered Al during gestation and evaluated fetal accumulation. Another 7 studies administered Al at least until birth and then evaluated accumulation in mothers and/or pups. These 14 studies included 4 different Al compounds (hydroxide, chloride, lactate, and citrate) administered by 4 different routes (gavage, feed, intraperitoneal injection, and subcutaneous injection) with total doses ranging from 13.5 to 8,400 mg/kg. Fetal Al levels were not increased in 6 of 7 studies and pup Al levels were not increased in 4 of 5 studies in which they were measured. Maternal Al levels were increased in some studies, but there was no consistent pattern of organ-specific accumulation and several positive studies were contradicted by subsequent reports from the same laboratory. Placental levels were increased in 6 of 9 studies and were greater than corresponding fetal levels. The weight of evidence in these studies suggests that environmental and dietary Al exposures are unlikely to pose risks of Al accumulation to pregnant animals or their fetuses.

[1]  N. Bishop,et al.  Aluminum neurotoxicity in preterm infants receiving intravenous-feeding solutions. , 1997, The New England journal of medicine.

[2]  Á. Miklósi,et al.  The effect of social learning on a conditioned avoidance response of rats treated prenatally with aluminum lactate. , 1997, Neurotoxicology and teratology.

[3]  M. Jensen,et al.  Effect of casein phosphopeptides on zinc and calcium absorption from bread meals. , 1997, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[4]  H. Wiśniewski,et al.  Oral aluminum administration during pregnancy and lactation produces gastric and renal lesions in rat mothers and delay in CNS development of their pups. , 1996, Molecular and chemical neuropathology.

[5]  W. Forbes,et al.  Speciation of aluminum in biological systems. , 1996, Journal of toxicology and environmental health.

[6]  W. D. Ehmann,et al.  Standardization in biological analyses of aluminum: what are the needs? , 1996, Journal of toxicology and environmental health.

[7]  M. Golub,et al.  What we know and what we need to know about developmental aluminum toxicity. , 1996, Journal of toxicology and environmental health.

[8]  S. Agarwal,et al.  Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium. , 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[9]  M. Golub,et al.  Behavioral performance of Swiss Webster mice exposed to excess dietary aluminum during development or during development and as adults. , 1995, Toxicology and applied pharmacology.

[10]  M. Chang,et al.  Comparison of tissue retention of aluminum and Ga-67: effects of iron status in rats. , 1995, Toxicology.

[11]  L. Danielsson,et al.  Bioavailability of labile aluminium in acidic drinking water: a study in the rat. , 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[12]  D. Newton,et al.  Human metabolism of aluminium-26 and gallium-67 injected as citrates , 1995, Human & experimental toxicology.

[13]  R. Bertani,et al.  Perspective. Analytical validation of a general protocol for the preparation of dose-controlled solutions in aluminium toxicology , 1995 .

[14]  J. Gentleman,et al.  Geochemical Risk Factors for Mental Functioning, Based on the Ontario Longitudinal Study of Aging (LSA) V. Comparisons of the Results, relevant to Aluminum Water Concentrations, obtained from the LSA and from Death Certificates mentioning Dementia , 1995, Canadian Journal on Aging / La Revue canadienne du vieillissement.

[15]  L. Danielsson,et al.  Aluminium fractionation in a simulated rat stomach: an in vitro study. , 1995, The Analyst.

[16]  J. Trojanowski,et al.  Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau , 1994, Neuron.

[17]  R. Martin Aluminum: A Neurotoxic Product of Acid Rain , 1994 .

[18]  J. Domingo,et al.  Lack of maternal and developmental toxicity in mice given high doses of aluminium hydroxide and ascorbic acid during gestation. , 1994, Pharmacology & toxicology.

[19]  E. Alleva,et al.  Early exposure to aluminium affects eight-arm maze performance and hippocampal nerve growth factor levels in adult mice , 1994, Neuroscience Letters.

[20]  M. Golub,et al.  Developmental patterns of aluminum in mouse brain and effects of dietary aluminum excess on manganese deficiency. , 1993, Toxicology.

[21]  A. Manning,et al.  Alterations to the pattern of ultrasonic calling after prenatal exposure to aluminium sulfate. , 1993, Behavioral and neural biology.

[22]  R. Coll,et al.  Contamination of biological samples in metal determination. , 1993, Clinica chimica acta; international journal of clinical chemistry.

[23]  T. Misawa,et al.  Effects of prenatal aluminum treatment on development and behavior in the rat. , 1993, The Journal of toxicological sciences.

[24]  R. P. Thompson,et al.  The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption , 1993, Proceedings of the Nutrition Society.

[25]  N. Priest The bioavailability and metabolism of aluminium compounds in man , 1993, Proceedings of the Nutrition Society.

[26]  W. D. Ehmann,et al.  Laser microprobe analysis of brain aluminum in Alzheimer' disease , 1993, Annals of neurology.

[27]  T. Ittel Determinants of gastrointestinal absorption and distribution of aluminium in health and uraemia. , 1993, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[28]  B. Mcdonald,et al.  Absence of aluminium in neuritic plaque cores in Alzheimer's disease , 1992, Nature.

[29]  David R. Williams,et al.  Chemical speciation of aluminium in blood plasma with reference to silica , 1992 .

[30]  W. R. Harris,et al.  Equilibrium model for speciation of aluminum in serum. , 1992, Clinical chemistry.

[31]  M. Golub,et al.  Neurodevelopmental effect of aluminum in mice: fostering studies. , 1992, Neurotoxicology and teratology.

[32]  G. Voet Intestinal absorption of aluminium. , 1992 .

[33]  W. D. Ehmann,et al.  Brain aluminum in Alzheimer's disease using an improved GFAAS method. , 1992, Neurotoxicology.

[34]  A. Manning,et al.  Long-term effects of aluminium on the fetal mouse brain. , 1992, Life sciences.

[35]  C. Richart,et al.  Effect of ascorbic acid on gastrointestinal aluminium absorption , 1991, The Lancet.

[36]  C. Ecelbarger,et al.  Dietary citrate and kidney function affect aluminum, zinc and iron utilization in rats. , 1991, The Journal of nutrition.

[37]  P. Seabright,et al.  Aluminium absorption studied by 26Al tracer , 1991, The Lancet.

[38]  J. B. Henderson,et al.  Ranitidine suppresses aluminium absorption in man. , 1991, Clinical science.

[39]  J. Domingo,et al.  Developmental toxicity evaluation of oral aluminum in rats: influence of citrate. , 1991, Neurotoxicology and teratology.

[40]  J. Hauw,et al.  Absence of aluminium in Alzheimer's disease brain tissue: Electron microprobe and ion microprobe studie , 1991, Neuroscience Letters.

[41]  W. Lukiw,et al.  WOULD DECREASED ALUMINIUM INGESTION REDUCED THE INCIDENCE OF ALZHEIMER'S DISEASE ? , 1991 .

[42]  J. Domingo,et al.  Evaluation of the maternal and developmental toxicity of aluminum from high doses of aluminum hydroxide in rats. , 1990, Veterinary and human toxicology.

[43]  R. Cody,et al.  The effect of oral bases on enteral aluminum absorption. , 1990, Archives of internal medicine.

[44]  D. Burnel,et al.  Developmental alterations in offspring of female rats orally intoxicated by aluminum lactate at different gestation periods. , 1990, Teratology.

[45]  G. Taylor,et al.  Gallium‐67 as a Potential Marker for Aluminium Transport in Rat Brain: Implications for Alzheimer's Disease , 1990, Journal of neurochemistry.

[46]  B. Molitoris,et al.  Site and mechanism of enhanced gastrointestinal absorption of aluminum by citrate. , 1989, Kidney international.

[47]  B. Molitoris,et al.  Citrate: a major factor in the toxicity of orally administered aluminum compounds. , 1989, Kidney international.

[48]  A. Scheibel,et al.  A Reexamination of Aluminum in Alzheimer's Disease: Analysis by Energy Dispersive X-ray Microprobe and Flameless Atomic Absorption Spectrophotometry , 1989, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[49]  V. Bernuzzi,et al.  Developmental alternations in offspring of female rats orally intoxicated by aluminum chloride or lactate during gestation. , 1989, Teratology.

[50]  M. Golub,et al.  Neurobehavioral effects in offspring of mice given excess aluminum in diet during gestation and lactation. , 1989, Neurotoxicology and teratology.

[51]  G. Voet,et al.  Intestinal absorption of aluminum in rats: stimulation by citric acid and inhibition by dinitrophenol. , 1989 .

[52]  F. Regnier,et al.  Influence of dietary constituents on intestinal absorption of aluminum. , 1989, Kidney international.

[53]  J. Domingo,et al.  Lack of teratogenicity of aluminum hydroxide in mice. , 1989, Life sciences.

[54]  J. L. Paternáin,et al.  Embryotoxic and teratogenic effects of aluminum nitrate in rats upon oral administration. , 1988, Teratology.

[55]  J. Weber An interlaboratory comparison programme for several toxic substances in blood and urine. , 1988, The Science of the total environment.

[56]  A. R. Byrne,et al.  Certification of a second-generation biological reference material (freeze-dried human serum) for trace element determinations , 1988 .

[57]  J. L. Paternáin,et al.  The effects of aluminium ingestion on reproduction and postnatal survival in rats. , 1987, Life sciences.

[58]  M. Golub,et al.  Maternal and developmental toxicity of chronic aluminum exposure in mice , 1987 .

[59]  R. Martin The chemistry of aluminum as related to biology and medicine. , 1986, Clinical chemistry.

[60]  A. Cedergren,et al.  Dietary citric acid enhances absorption of aluminum in antacids. , 1986, Clinical chemistry.

[61]  P. O. Ganrot Metabolism and possible health effects of aluminum. , 1986, Environmental health perspectives.

[62]  L. Mandel,et al.  Primary active sodium transport, oxygen consumption, and ATP: coupling and regulation. , 1986, Kidney international.

[63]  J D Wilkins,et al.  Fetal-placental-maternal uptake of aluminum in mice following gestational exposure: effect of dose and route of administration. , 1986, Neurotoxicology.

[64]  G. Berlyne,et al.  Serum aluminum cannot be measured accurately. , 1985, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[65]  R. Yokel,et al.  Toxicity of gestational aluminum exposure to the maternal rabbit and offspring. , 1985, Toxicology and applied pharmacology.

[66]  S. F. Davis,et al.  Prenatal exposure to aluminum or stress: II. Behavioral and performance effects , 1985 .

[67]  J. T. Barach,et al.  What's new in genetic engineering of dairy starter cultures and dairy enzymes , 1985 .

[68]  S. F. Davis,et al.  Prenatal exposure to aluminum or stress: I. Birth-related and developmental effects , 1985 .

[69]  M. Burnatowska-Hledin,et al.  Microcytic anemia secondary to intraperitoneal aluminum in normal and uremic rats. , 1984, Kidney international.

[70]  M. Wide Effect of short-term exposure to five industrial metals on the embryonic and fetal development of the mouse. , 1984, Environmental research.

[71]  P. Kostyniak An electrothermal atomic absorption method for aluminum analysis in plasma: identification of sources of contamination in blood sampling procedures. , 1983, Journal of analytical toxicology.

[72]  B. Bennett Exposure of man to environmental nickel--an exposure commitment assessment. , 1982, The Science of the total environment.

[73]  G. Daston Fetal zinc deficiency as a mechanism for cadmium induced toxicity to the developing rat lung and pulmonary surfactant. , 1982, Toxicology.

[74]  W. D. Ehmann,et al.  Instrumental neutron activation analysis of brain aluminum in Alzheimer disease and aging , 1981, Annals of neurology.

[75]  I. Jakobson,et al.  Uptake, distribution and elimination of p-tert-butyltoluene (TBT) in mice by inhalation. , 2009, Acta pharmacologica et toxicologica.

[76]  J. Versieck,et al.  Measuring aluminum levels. , 1980, The New England journal of medicine.

[77]  G. Daston,et al.  Toxic effects of cadmium on the developing rat lung. I. Altered pulmonary surfactant and the induction of respiratory distress syndrome. , 1979, Journal of toxicology and environmental health.

[78]  R. Ahokas,et al.  Cadmium uptake by the rat embryo as a function of gestational age. , 1979, American journal of obstetrics and gynecology.

[79]  K. Iqbal,et al.  Brain aluminum in aging and Alzheimer disease , 1979, Neurology.

[80]  S. Sprague,et al.  Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat , 1979, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[81]  W. D. Kaehny,et al.  Gastrointestinal absorption of aluminum from aluminum-containing antacids. , 1977, The New England journal of medicine.

[82]  D. Crapper,et al.  Aluminium, neurofibrillary degeneration and Alzheimer's disease. , 1976, Brain : a journal of neurology.

[83]  G. Lucier,et al.  Placental transfer of cadmium in rats: influence of dose and gestational age. , 1975, Environmental health perspectives.

[84]  K. Mackenzie The biochemistry of aluminium: Effect of aluminium on growth and reproduction in the rat. IV. The occurrence of aluminium in the thyroid. V. Intestinal absorption of aluminium in the rabbit. , 1932, The Biochemical journal.