The distribution of haptoglobin and transferrin types in northeast New Guinea.

This paper reports haptoglobin testing of 2,029 serum specimens and transferrin typing of 1,911 specimens obtained from villages representing a wide range of environments and cultures in the Markham River Valley region of northeast New Guinea. The haptoglobin gene frequencies ranged from 90.0% to 61.4% for Hp1 and the frequency of the transferring gene Tfc ranged from 94.9% to 71.5%. Other transferrin genes present were TfD1 and, in low frequency, TfB Lae. Overall, no apparent correlations were found between the frequencies of these genes and altitudes, languages or distances of the villages studied up the valley. It was felt that the arguments put forward earlier emphasizing the role of genetic drift in determining gene distribution in New Guinea could be also applied to explain the distribution of the haptoglobin and transferrin genes in the Markham River Valley.

[1]  E. Giles,et al.  Distribution of beta-thalassemia trait and erythrocyte glucose-6-phosphate dehydrogenase deficiency in the Markham River Valley of New Guinea. , 1967, American journal of physical anthropology.

[2]  H. Sutton,et al.  Transferrin D1: Identity in Australian Aborigines and American Negroes , 1967, Science.

[3]  G. Fraser,et al.  Population genetic studies in the Congo. IV. Haptoglobin and transferrin serum groups in the Congo and in other African population.s. , 1966, American journal of human genetics.

[4]  E. Giles,et al.  MICRO‐EVOLUTION IN NEW GUINEA: THE ROLE OF GENETIC DRIFT * , 1966 .

[5]  D. Gajdusek,et al.  Haptoglobins and transferrins in Melanesia: relation to hemoglobin, serum haptoglobin and serum iron levels in population groups in Papua--New Guinea. , 1965, American journal of physical anthropology.

[6]  A. Steinberg,et al.  Gamma-Globulin Factors (Gm and Inv) in New Guinea: Anthropological Significance , 1965, Science.

[7]  H. Sutton,et al.  Human Transferrins C and D1: Chemical Difference in a Peptide , 1965, Science.

[8]  A. Baumgarten.  Computer Analysis of Concordance of Inherited Characteristics , 1965, Nature.

[9]  T. Arends,et al.  Transferrins in Venezuelan Indians: High Frequency of a Slow-Moving Variant , 1964, Science.

[10]  A. Baumgarten.  IDENTIFICATION OF CATALASE FOLLOWING ELECTROPHORESIS ON ACRYLAMIDE GELS. , 1963, Blood.

[11]  A. Baumgarten.  Micro Method of Haptoglobin Typing using Acrylamide Gels , 1963, Nature.

[12]  E. Giblett,et al.  Haptoglobin Types: Haptoglobin Sub-types in Three Racial Groups , 1963, Nature.

[13]  D. Gajdusek,et al.  Distribution pattern, population genetics and anthropological significance of thalassemia and abnormal hemoglobins in Melanesia. , 1962, American journal of physical anthropology.

[14]  J. Gorman,et al.  Distribution pattern of an inherited trait, red cell enzyme deficiency, in New Guinea and New Britain. , 1962, American journal of physical anthropology.

[15]  A. Bearn,et al.  Haptoglobin and transferrin variation in humans and primates: two new transferrins in Chinese and Japanese populations , 1962, Annals of human genetics.

[16]  D. Gajdusek,et al.  Studies on Kuru. V. A Blood Group Genetical Survey of the Kuru Region and other Parts of Papua-New Guinea. , 1961 .

[17]  J. Kariks,et al.  HAPTOGLOBIN AND TRANSFERRIN VARIANTS IN PEOPLES OF THE NEW GUINEA HIGHLANDS , 1960, Medical Journal of Australia.

[18]  A. Steinberg,et al.  The inheritance of serum haptoglobin types in American Negroes: evidence for a third allele Hp-2m. , 1960, American journal of human genetics.

[19]  C. Got,et al.  Detection of Hæmoglobin, Hæmoglobin–Haptoglobin Complexes and other Substances with Peroxidase Activity after Zone Electrophoresis , 1958, Nature.

[20]  M. D. Poulik.  Starch Gel Electrophoresis in a Discontinuous System of Buffers , 1957, Nature.

[21]  E. Giles,et al.  Distribution of the group specific (Gc) serum component in the populations of the Markham Valley, New Guinea. , 1967, American journal of physical anthropology.

[22]  R. Kirk.  The distribution of genetic markers in Australian Aborigines , 1965 .