CSF cells in multiple sclerosis

Mononuclear cells were analyzed in CSF and blood of 102 patients with MS. In CSF, the majority (78%) of cells were T lymphocytes (T3 +1, and the ratio of inducer (T4 +1 to suppressor/cytotoxic (T8 +) cells was 2:l. No characteristic alterations in CSF phenotypes could be related to changes in circulating T8 cells or to disease activity. In a group of 75 patients, CSF cell count was higher in patients with low numbers of circulating T8 cells than in those with normal T8 cells. Thus, decreases in suuuressor cells in the blood of MS patients are associated with CSF pleocytosis but not with fluctuations in the kio of different subsets in CSF. Furthermore, large numbers of T8 cells are not sequestered in CSF when these cells are decreased in peripheral blood.

[1]  W. L. Benedict,et al.  Multiple Sclerosis , 2007, Journal - Michigan State Medical Society.

[2]  S. Kam‐Hansen,et al.  Immunoglobulin-producing cells in CSF and blood from patients with multiple sclerosis and other inflammatory neurological diseases enumerated by Protein-A plaque assay , 1981, Journal of Neuroimmunology.

[3]  J. Degos,et al.  DEFICIT OF SUPPRESSOR T CELLS IN ACTIVE MULTIPLE SCLEROSIS , 1980, The Lancet.

[4]  L. Nadler,et al.  Characterization of a human B lymphocyte-specific antigen. , 1980, Journal of immunology.

[5]  D. Richman,et al.  Detection of in vivo stimulated cerebrospinal-fluid lymphocytes by flow cytometry in patients with multiple sclerosis. , 1980, The New England journal of medicine.

[6]  J. Wolinsky,et al.  CEREBROSPINAL-FLUID LYMPHOCYTE POPULATIONS AND IMMUNE COMPLEXES IN ACTIVE MULTIPLE SCLEROSIS , 1980, The Lancet.

[7]  E. Reinherz,et al.  Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. , 1980, The New England journal of medicine.

[8]  E. Reinherz,et al.  Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison , 1980, The Journal of experimental medicine.

[9]  E. Reinherz,et al.  A monoclonal antibody reactive with human peripheral blood monocytes. , 1980, Journal of immunology.

[10]  E. Reinherz,et al.  Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression , 1979, The Journal of experimental medicine.

[11]  S. Kam‐Hansen.  Reduced number of active T cells in cerebrospinal fluid in multiple sclerosis , 1979, Neurology.

[12]  J. Antel,et al.  Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity , 1979, Annals of neurology.

[13]  T. Strom,et al.  SPECIFICITY OF CELLULAR MIGRATION INTO CARDIAC ALLOGRAFTS IN RATS , 1978, Transplantation.

[14]  A. Frydén,et al.  B and T lymphocytes in cerebrospinal fluid and blood in multiple sclerosis, optic neuritis and mumps meningitis , 1978, Acta neurologica Scandinavica.

[15]  B. Zweiman,et al.  In vitro cell-mediated immunity of cerebrospinal-fluid lymphocytes to myelin basic protein in primary demyelinating diseases. , 1977, The New England journal of medicine.

[16]  J. A. Robinson,et al.  Lymphocyte subpopulations in human cerebrospinal fluid , 1976, Neurology.

[17]  W. Sheremata,et al.  Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis , 1976, Neurology.

[18]  M. Sandberg‐Wollheim,et al.  Lymphocyte Subpopulations in the Cerebrospinal Fluid and Peripheral Blood in Patients with Multiple Sclerosis , 1975 .

[19]  M. Sandberg‐Wollheim,et al.  Immunoglobulin Synthesis In Vitro by Cerebrospinal Fluid Cells in Patients with Multiple Sclerosis , 1974, Scandinavian journal of immunology.

[20]  M. Oehmichen,et al.  Cytokinetic studies on the origin of cells of the cerebrospinal fluid , 1974 .

[21]  H. Link,et al.  Immunoglobulin abnormalities in multiple sclerosis. , 1973, Annals of clinical research.

[22]  P. Y. Paterson,et al.  Multiple sclerosis: an immunologic reassessment. , 1973, Journal of chronic diseases.

[23]  E. Reinherz,et al.  Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings. , 1980, The New England journal of medicine.

[24]  H. Nyland,et al.  Multiple sclerosis. T lymphocytes in cerebrospinal fluid and blood. , 1978, European neurology.