The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assembly.

Individual steps in the assembly of RNA polymerase II and general initiation factors into a preinitiation complex serve as points of control for activators, whose functions require additional cofactors. The full range of induction by activators appears to involve both the reversal of negative constraints and net positive effects on promoter interactions with general factors.

[1]  J. Nevins,et al.  Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation , 1988, Cell.

[2]  J. Workman,et al.  Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly , 1988, Cell.

[3]  Robert Tjian,et al.  Mechanism of transcriptional activation by Sp1: Evidence for coactivators , 1990, Cell.

[4]  Roger D. Kornberg,et al.  A mediator required for activation of RNA polymerase II transcription in vitro , 1991, Nature.

[5]  J. Greenblatt,et al.  Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II , 1989, Nature.

[6]  P Chambon,et al.  Organization and expression of eucaryotic split genes coding for proteins. , 1981, Annual review of biochemistry.

[7]  J. Workman,et al.  Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II , 1987, Cell.

[8]  R. Roeder,et al.  Physical analysis of transcription preinitiation complex assembly on a class II gene promoter. , 1988, Science.

[9]  P. Lieberman,et al.  Cloning of a transcriptionally active human TATA binding factor. , 1990, Science.

[10]  P. Sharp,et al.  Five intermediate complexes in transcription initiation by RNA polymerase II , 1989, Cell.

[11]  R. Tjian,et al.  Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation , 1991, Cell.

[12]  M. Horikoshi,et al.  Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA box-promoter interactions of TFIID , 1988, Molecular and cellular biology.

[13]  Michael Carey,et al.  A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives , 1990, Nature.

[14]  R. Tjian,et al.  Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. , 1989, Science.

[15]  M. Horikoshi,et al.  A plant DNA-binding protein increases the number of active preinitiation complexes in a human in vitro transcription system. , 1990, Genes & development.

[16]  R. Roeder,et al.  Activation of class II gene transcription by regulatory factors is potentiated by a novel activity , 1991, Cell.

[17]  C. Ingles,et al.  Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID , 1990, Nature.

[18]  A. Sentenac,et al.  RNA polymerase B (II) and general transcription factors. , 1990, Annual review of biochemistry.

[19]  J. Workman,et al.  Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains. , 1991, Genes & development.

[20]  M. Grunstein,et al.  Nucleosomes: regulators of transcription. , 1990, Trends in genetics : TIG.

[21]  Masami Horikoshi,et al.  Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex , 1988, Cell.

[22]  Masami Horikoshi,et al.  Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID) , 1990, Nature.

[23]  M. Ptashne.  How eukaryotic transcriptional activators work , 1988, Nature.

[24]  B. Lewin.  Commitment and activation at pol II promoters: A tail of protein-protein interactions , 1990, Cell.

[25]  D. Reinberg,et al.  Cloning of a human gene encoding the general transcription initiation factor IIB , 1991, Nature.

[26]  M. Ptashne,et al.  Activators and targets , 1990, Nature.

[27]  M. Ptashne,et al.  GAL11P: A yeast mutation that potentiates the effect of weak GAL4-derived activators , 1990, Cell.

[28]  D. Reinberg,et al.  Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex , 1990, Molecular and cellular biology.

[29]  Michael R. Green,et al.  Mechanism of action of an acidic transcriptional activator in vitro , 1991, Cell.