The effect of ligation on infection of the patent ductus arteriosus

SIX years ago Gross (Gross and Hubbard, 1939), of Boston, Mass., performed the first successful ligation of a persistently patent ductus arteriosus, and sixteen months later the first ligation of a case complicated by subacute bacterial infection was performed in this country with a successful result (Bourne, Keele, and Tubbs, 1941). In this communication 9 infected cases treated by ligation are reported, 6 of these patients being well to-day and apparently cured. As so little has been published on this subject in the English literature, the essential anatomy and physiology of the ductus arteriosus and the pathological effects of its persistence, with particular reference to the complication of subacute bacterial infection, are described first.

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