Structure of two human beta‐actin‐related processed genes one of which is located next to a simple repetitive sequence.

From a human gene library we have isolated and sequenced a beta‐actin‐like pseudogene, H beta Ac‐psi 2, which lacks intervening sequences and contains several mutations resulting in frame‐shifts, stop codons and in a departure from the known beta‐actin protein sequence. We have also extended our sequence work on the intronless human beta‐actin‐related pseudogene H beta Ac‐psi 1 described previously and we find that both genes are processed genes ending in a poly(dA) tract and flanked by direct repeats. The gene H beta Ac‐psi 2 is preceded by a 230‐bp region in which the simple sequence 5′‐GAAA‐3′ is repeated greater than 40 times. This satellite‐like sequence is highly repetitive in the human genome.