Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.

[1]  A. Goldberg,et al.  What the Archaeal PAN–Proteasome Complex and Bacterial ATP‐Dependent Proteases Can Teach Us About the 26S Proteasome , 2007 .

[2]  D. Nandi,et al.  The ubiquitin-proteasome system , 2006, Journal of Biosciences.

[3]  A. Goldberg,et al.  Proteasomes and their associated ATPases: a destructive combination. , 2006, Journal of structural biology.

[4]  Thomas Walz,et al.  ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. , 2005, Molecular cell.

[5]  Tania A. Baker,et al.  Asymmetric Interactions of ATP with the AAA+ ClpX6 Unfoldase: Allosteric Control of a Protein Machine , 2005, Cell.

[6]  C. Hill,et al.  The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. , 2005, Molecules and Cells.

[7]  Axel T Brunger,et al.  Nucleotide dependent motion and mechanism of action of p97/VCP. , 2005, Journal of molecular biology.

[8]  A. Goldberg.  Nobel Committee Tags Ubiquitin for Distinction , 2005, Neuron.

[9]  G. Demartino.  Purification of PA700, the 19S regulatory complex of the 26S proteasome. , 2005, Methods in enzymology.

[10]  S. Elsasser,et al.  Characterization of the proteasome using native gel electrophoresis. , 2005, Methods in enzymology.

[11]  J. Adams.  Proteasome Inhibitors in Cancer Therapy , 2004 .

[12]  C. Hill,et al.  The pore of activated 20S proteasomes has an ordered 7‐fold symmetric conformation , 2003, The EMBO journal.

[13]  R. Huber,et al.  Substrate access and processing by the 20S proteasome core particle. , 2003, The international journal of biochemistry & cell biology.

[14]  A. Goldberg,et al.  ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. , 2003, Molecular cell.

[15]  Dissecting various ATP-dependent steps involved in proteasomal degradation. , 2003, Molecular cell.

[16]  A. May,et al.  Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle , 2002, Nature Structural Biology.

[17]  L. Esser,et al.  Crystal Structure of ClpA, an Hsp100 Chaperone and Regulator of ClpAP Protease* , 2002, The Journal of Biological Chemistry.

[18]  A. Goldberg,et al.  The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. , 2002, Molecular immunology.

[19]  H. Ploegh,et al.  Multiple associated proteins regulate proteasome structure and function. , 2002, Molecular cell.

[20]  S. Eom,et al.  The C-terminal Tails of HslU ATPase Act as a Molecular Switch for Activation of HslV Peptidase* , 2002, The Journal of Biological Chemistry.

[21]  A. Goldberg,et al.  Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes , 2002, The EMBO journal.

[22]  A. Ciechanover,et al.  The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. , 2002, Physiological reviews.

[23]  Noa Reis,et al.  Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome , 2001, The EMBO journal.

[24]  J. Wang,et al.  Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU. , 2001, Structure.

[25]  A. Goldberg,et al.  The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. , 2001, Molecular cell.

[26]  A. Goldberg,et al.  Proteasome inhibitors: from research tools to drug candidates. , 2001, Chemistry & biology.

[27]  C. Hill,et al.  Structural basis for the activation of 20S proteasomes by 11S regulators , 2000, Nature.

[28]  R. Huber,et al.  A gated channel into the proteasome core particle , 2000, Nature Structural Biology.

[29]  Michael R Sawaya,et al.  Crystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides , 2000, Cell.

[30]  Robert Huber,et al.  The structures of HslU and the ATP-dependent protease HslU–HslV , 2000, Nature.

[31]  A. Goldberg,et al.  An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes* , 1999, The Journal of Biological Chemistry.

[32]  C. Slaughter,et al.  The Proteasome, a Novel Protease Regulated by Multiple Mechanisms* , 1999, The Journal of Biological Chemistry.

[33]  W. Baumeister,et al.  The 26S proteasome: a molecular machine designed for controlled proteolysis. , 1999, Annual review of biochemistry.

[34]  C. Hill,et al.  Identification of an activation region in the proteasome activator REGalpha. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[35]  W. Baumeister,et al.  26S proteasome structure revealed by three-dimensional electron microscopy. , 1998, Journal of structural biology.

[36]  R. Huber,et al.  Structure of 20S proteasome from yeast at 2.4Å resolution , 1997, Nature.

[37]  K Tanaka,et al.  Structure and functions of the 20S and 26S proteasomes. , 1996, Annual review of biochemistry.

[38]  R. Huber,et al.  Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. , 1995, Science.

[39]  C. Slaughter,et al.  PA28, an activator of the 20 S proteasome, is inactivated by proteolytic modification at its carboxyl terminus. , 1993, The Journal of biological chemistry.

[40]  B. Ames.  ASSAY OF INORGANIC PHOSPHATE, TOTAL PHOSPHATE AND PHOSPHATASE , 1966 .