CCL17 signals through CCR8 to induce CCL3 expression and restrain atheroprotective Tregs
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Yimin Yan | C. Weber | L. Holdt | D. Teupser | Y. Döring | A. Habenicht | P. Hundelshausen | Cláudia | A. Faussner | S. Gencer | E. V. D. Vorst | C. Yin | Y. Jansen | Monaco | C. Neideck | Xi Zhang | S. Bayasgalan | Xavier | J. Leberzammer | Michael Hristov | Blanchet | Manuela Kemmerich | F. LinseyJ. | Peters | Inhye | Park | Carlos Neideck
[1] W. Dehaen,et al. Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists. , 2021, Biochemical pharmacology.
[2] Amal J. Ali,et al. Regulatory T Cell Stability and Plasticity in Atherosclerosis , 2020, Cells.
[3] N. Mukaida,et al. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis , 2020, Nature Communications.
[4] K. Ley,et al. T cell subsets and functions in atherosclerosis , 2020, Nature Reviews Cardiology.
[5] G. Lombardi,et al. Getting to the Heart of the Matter: The Role of Regulatory T-Cells (Tregs) in Cardiovascular Disease (CVD) and Atherosclerosis , 2019, Front. Immunol..
[6] T. Winkler,et al. CD83 orchestrates immunity towards self and non-self in dendritic cells. , 2019, JCI insight.
[7] E. McGhee,et al. Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans , 2019, Science Immunology.
[8] C. Weber,et al. Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. , 2019, Journal of molecular and cellular cardiology.
[9] S. Jane,et al. Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis , 2018, Cell Death & Disease.
[10] A. Luster,et al. The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response , 2018, Immunity.
[11] Daniel O. Villarreal,et al. Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer. , 2018, Cancer research.
[12] A. Saliba,et al. Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells , 2018, Front. Immunol..
[13] G. Stirparo,et al. Immunotherapy for cardiovascular disease , 2017, Journal of leukocyte biology.
[14] K. Steinbrink,et al. Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity , 2017, Front. Immunol..
[15] A. Zernecke,et al. Antigen‐presenting dendritic cells in atherosclerosis , 2017, European journal of pharmacology.
[16] A. Dattola,et al. The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins , 2017, Scientific Reports.
[17] S. Lira,et al. CCR8+FOXp3+ Treg cells as master drivers of immune regulation , 2017, Proceedings of the National Academy of Sciences.
[18] R. Förster,et al. Dendritic cell migration in health and disease , 2016, Nature Reviews Immunology.
[19] K. Steinbrink,et al. IL-10–Modulated Human Dendritic Cells for Clinical Use: Identification of a Stable and Migratory Subset with Improved Tolerogenic Activity , 2016, The Journal of Immunology.
[20] M. Mann,et al. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans , 2016, Nature Communications.
[21] Even Fossum,et al. Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery. , 2016, Immunity.
[22] A. Arce-Sillas,et al. Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation , 2016, Journal of immunology research.
[23] A. Gholami,et al. CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis. , 2016, Circulation research.
[24] Shuyang Zhang,et al. Serum chemokine CCL17/thymus activation and regulated chemokine is correlated with coronary artery diseases. , 2015, Atherosclerosis.
[25] Experimental Therapeutics,et al. Correction to “International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors” , 2014, Pharmacological Reviews.
[26] A. Mantovani,et al. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors , 2014, Pharmacological Reviews.
[27] W. Shreffler,et al. Identification of human CCR8 as a CCL18 receptor , 2013, The Journal of experimental medicine.
[28] R. Guo,et al. Atorvastatin Inhibits the 5-Lipoxygenase Pathway and Expression of CCL3 to Alleviate Atherosclerotic Lesions in Atherosclerotic ApoE Knockout Mice , 2013, Journal of cardiovascular pharmacology.
[29] G. Bricca,et al. Identification of two genes potentially associated in iron-heme homeostasis in human carotid plaque using microarray analysis , 2013, Journal of Biosciences.
[30] T. Lüscher,et al. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. , 2013, The Journal of clinical investigation.
[31] T. V. van Berkel,et al. Leukocyte-Specific CCL3 Deficiency Inhibits Atherosclerotic Lesion Development by Affecting Neutrophil Accumulation , 2013, Arteriosclerosis, thrombosis, and vascular biology.
[32] P. Murphy,et al. Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice. , 2013, Cardiovascular research.
[33] M. Hristov,et al. Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes , 2013, EMBO molecular medicine.
[34] Yun M. Zhao,et al. mTORC2-PKBα/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis. , 2013, The Journal of investigative dermatology.
[35] L. Su,et al. Expansion of CCR8+ Inflammatory Myeloid Cells in Cancer Patients with Urothelial and Renal Carcinomas , 2013, Clinical Cancer Research.
[36] N. Xia,et al. Impaired Thymic Export and Increased Apoptosis Account for Regulatory T Cell Defects in Patients with Non-ST Segment Elevation Acute Coronary Syndrome* , 2012, The Journal of Biological Chemistry.
[37] R. Steinman. Decisions about dendritic cells: past, present, and future. , 2012, Annual review of immunology.
[38] H. Lehr,et al. CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. , 2012, Gastroenterology.
[39] M. Jochum,et al. Helix 8 Plays a Crucial Role in Bradykinin B2 Receptor Trafficking and Signaling , 2011, The Journal of Biological Chemistry.
[40] Steffen Jung,et al. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. , 2011, The Journal of clinical investigation.
[41] S. Lira,et al. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells , 2011, Nature Immunology.
[42] H. Drexler,et al. Chemokine Receptor 7 Knockout Attenuates Atherosclerotic Plaque Development , 2010, Circulation.
[43] N. Novak,et al. Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells , 2010, Proceedings of the National Academy of Sciences.
[44] C. Weston,et al. Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver , 2010, The Journal of Immunology.
[45] G. Schuler,et al. ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21 , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[46] G. Lanfranchi,et al. Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries , 2009, BMC Genomics.
[47] M. Hensel,et al. Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis. , 2008, Blood.
[48] A. Rot,et al. CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells , 2007, The Journal of experimental medicine.
[49] Christian Weber,et al. Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice , 2006, Arteriosclerosis, thrombosis, and vascular biology.
[50] G. Keren,et al. Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes. , 2006, European heart journal.
[51] M. Cybulsky,et al. Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis , 2006, The Journal of experimental medicine.
[52] A. Zernecke,et al. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. , 2006, Blood.
[53] O. Kaminuma,et al. Functional chemokine receptors in allergic diseases: is CCR8 a novel therapeutic target? , 2006, Mini reviews in medicinal chemistry.
[54] R. Flavell,et al. Natural regulatory T cells control the development of atherosclerosis in mice , 2006, Nature Medicine.
[55] M. Dorf,et al. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor , 2005, The Journal of experimental medicine.
[56] S. Lira,et al. CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice1 , 2005, The Journal of Immunology.
[57] R. Koenen,et al. Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. , 2005, Blood.
[58] K. Pfeffer,et al. CCR4‐deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model , 2005, European journal of immunology.
[59] J. Parma,et al. Single-nucleotide polymorphism genotyping by melting analysis of dual-labeled probes: examples using factor V Leiden and prothrombin 20210A mutations. , 2003, Clinical chemistry.
[60] J. Alferink,et al. Compartmentalized Production of CCL17 In Vivo , 2003, The Journal of experimental medicine.
[61] A. Iellem,et al. Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells , 2001, The Journal of experimental medicine.
[62] H. Niederegger,et al. Network of Vascular-Associated Dendritic Cells in Intima of Healthy Young Individuals , 2001, Arteriosclerosis, thrombosis, and vascular biology.
[63] P. Allavena,et al. Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity1 , 2001, The Journal of Immunology.
[64] B. Damaj,et al. Human NK Cells Express CC Chemokine Receptors 4 and 8 and Respond to Thymus and Activation-Regulated Chemokine, Macrophage-Derived Chemokine, and I-3091 , 2000, The Journal of Immunology.
[65] M. Billah,et al. The assignment of chemokine‐chemokine receptor pairs: TARC and MIP‐1β are not ligands for human CC‐chemokine receptor 8 , 1999, European journal of immunology.
[66] A. Mantovani,et al. Identification of the CC chemokines TARC and macrophage inflammatory protein‐1β as novel functional ligands for the CCR8 receptor , 1998, European journal of immunology.
[67] O. Yoshie,et al. The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4* , 1997, The Journal of Biological Chemistry.
[68] Shuyang Zhang,et al. Association Between a CCL17 Genetic Variant and Risk of Coronary Artery Disease in a Chinese Han Population. , 2017, Circulation journal : official journal of the Japanese Circulation Society.
[69] T. Bonner,et al. Brief Definitive Report Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309 , 2022 .
[70] R. Steinman,et al. Brief Definitive Report Identifi Cation of Antigen-presenting Dendritic Cells in Mouse Aorta and Cardiac Valves , 2022 .