CCL17 signals through CCR8 to induce CCL3 expression and restrain atheroprotective Tregs

Institute for Cardiovascular Prevention (IPEK), LMU Munich, Munich, Germany; Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Switzerland; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, the Netherlands; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom; Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany.

[1]  W. Dehaen,et al.  Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists. , 2021, Biochemical pharmacology.

[2]  Amal J. Ali,et al.  Regulatory T Cell Stability and Plasticity in Atherosclerosis , 2020, Cells.

[3]  N. Mukaida,et al.  Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis , 2020, Nature Communications.

[4]  K. Ley,et al.  T cell subsets and functions in atherosclerosis , 2020, Nature Reviews Cardiology.

[5]  G. Lombardi,et al.  Getting to the Heart of the Matter: The Role of Regulatory T-Cells (Tregs) in Cardiovascular Disease (CVD) and Atherosclerosis , 2019, Front. Immunol..

[6]  T. Winkler,et al.  CD83 orchestrates immunity towards self and non-self in dendritic cells. , 2019, JCI insight.

[7]  E. McGhee,et al.  Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans , 2019, Science Immunology.

[8]  C. Weber,et al.  Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. , 2019, Journal of molecular and cellular cardiology.

[9]  S. Jane,et al.  Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis , 2018, Cell Death & Disease.

[10]  A. Luster,et al.  The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response , 2018, Immunity.

[11]  Daniel O. Villarreal,et al.  Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer. , 2018, Cancer research.

[12]  A. Saliba,et al.  Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells , 2018, Front. Immunol..

[13]  G. Stirparo,et al.  Immunotherapy for cardiovascular disease , 2017, Journal of leukocyte biology.

[14]  K. Steinbrink,et al.  Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity , 2017, Front. Immunol..

[15]  A. Zernecke,et al.  Antigen‐presenting dendritic cells in atherosclerosis , 2017, European journal of pharmacology.

[16]  A. Dattola,et al.  The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins , 2017, Scientific Reports.

[17]  S. Lira,et al.  CCR8+FOXp3+ Treg cells as master drivers of immune regulation , 2017, Proceedings of the National Academy of Sciences.

[18]  R. Förster,et al.  Dendritic cell migration in health and disease , 2016, Nature Reviews Immunology.

[19]  K. Steinbrink,et al.  IL-10–Modulated Human Dendritic Cells for Clinical Use: Identification of a Stable and Migratory Subset with Improved Tolerogenic Activity , 2016, The Journal of Immunology.

[20]  M. Mann,et al.  Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans , 2016, Nature Communications.

[21]  Even Fossum,et al.  Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery. , 2016, Immunity.

[22]  A. Arce-Sillas,et al.  Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation , 2016, Journal of immunology research.

[23]  A. Gholami,et al.  CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis. , 2016, Circulation research.

[24]  Shuyang Zhang,et al.  Serum chemokine CCL17/thymus activation and regulated chemokine is correlated with coronary artery diseases. , 2015, Atherosclerosis.

[25]  Experimental Therapeutics,et al.  Correction to “International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors” , 2014, Pharmacological Reviews.

[26]  A. Mantovani,et al.  International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors , 2014, Pharmacological Reviews.

[27]  W. Shreffler,et al.  Identification of human CCR8 as a CCL18 receptor , 2013, The Journal of experimental medicine.

[28]  R. Guo,et al.  Atorvastatin Inhibits the 5-Lipoxygenase Pathway and Expression of CCL3 to Alleviate Atherosclerotic Lesions in Atherosclerotic ApoE Knockout Mice , 2013, Journal of cardiovascular pharmacology.

[29]  G. Bricca,et al.  Identification of two genes potentially associated in iron-heme homeostasis in human carotid plaque using microarray analysis , 2013, Journal of Biosciences.

[30]  T. Lüscher,et al.  Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. , 2013, The Journal of clinical investigation.

[31]  T. V. van Berkel,et al.  Leukocyte-Specific CCL3 Deficiency Inhibits Atherosclerotic Lesion Development by Affecting Neutrophil Accumulation , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[32]  P. Murphy,et al.  Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice. , 2013, Cardiovascular research.

[33]  M. Hristov,et al.  Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes , 2013, EMBO molecular medicine.

[34]  Yun M. Zhao,et al.  mTORC2-PKBα/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis. , 2013, The Journal of investigative dermatology.

[35]  L. Su,et al.  Expansion of CCR8+ Inflammatory Myeloid Cells in Cancer Patients with Urothelial and Renal Carcinomas , 2013, Clinical Cancer Research.

[36]  N. Xia,et al.  Impaired Thymic Export and Increased Apoptosis Account for Regulatory T Cell Defects in Patients with Non-ST Segment Elevation Acute Coronary Syndrome* , 2012, The Journal of Biological Chemistry.

[37]  R. Steinman Decisions about dendritic cells: past, present, and future. , 2012, Annual review of immunology.

[38]  H. Lehr,et al.  CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. , 2012, Gastroenterology.

[39]  M. Jochum,et al.  Helix 8 Plays a Crucial Role in Bradykinin B2 Receptor Trafficking and Signaling , 2011, The Journal of Biological Chemistry.

[40]  Steffen Jung,et al.  CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. , 2011, The Journal of clinical investigation.

[41]  S. Lira,et al.  Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells , 2011, Nature Immunology.

[42]  H. Drexler,et al.  Chemokine Receptor 7 Knockout Attenuates Atherosclerotic Plaque Development , 2010, Circulation.

[43]  N. Novak,et al.  Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells , 2010, Proceedings of the National Academy of Sciences.

[44]  C. Weston,et al.  Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver , 2010, The Journal of Immunology.

[45]  G. Schuler,et al.  ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21 , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[46]  G. Lanfranchi,et al.  Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries , 2009, BMC Genomics.

[47]  M. Hensel,et al.  Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis. , 2008, Blood.

[48]  A. Rot,et al.  CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells , 2007, The Journal of experimental medicine.

[49]  Christian Weber,et al.  Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[50]  G. Keren,et al.  Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes. , 2006, European heart journal.

[51]  M. Cybulsky,et al.  Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis , 2006, The Journal of experimental medicine.

[52]  A. Zernecke,et al.  Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. , 2006, Blood.

[53]  O. Kaminuma,et al.  Functional chemokine receptors in allergic diseases: is CCR8 a novel therapeutic target? , 2006, Mini reviews in medicinal chemistry.

[54]  R. Flavell,et al.  Natural regulatory T cells control the development of atherosclerosis in mice , 2006, Nature Medicine.

[55]  M. Dorf,et al.  Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor , 2005, The Journal of experimental medicine.

[56]  S. Lira,et al.  CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice1 , 2005, The Journal of Immunology.

[57]  R. Koenen,et al.  Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. , 2005, Blood.

[58]  K. Pfeffer,et al.  CCR4‐deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model , 2005, European journal of immunology.

[59]  J. Parma,et al.  Single-nucleotide polymorphism genotyping by melting analysis of dual-labeled probes: examples using factor V Leiden and prothrombin 20210A mutations. , 2003, Clinical chemistry.

[60]  J. Alferink,et al.  Compartmentalized Production of CCL17 In Vivo , 2003, The Journal of experimental medicine.

[61]  A. Iellem,et al.  Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells , 2001, The Journal of experimental medicine.

[62]  H. Niederegger,et al.  Network of Vascular-Associated Dendritic Cells in Intima of Healthy Young Individuals , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[63]  P. Allavena,et al.  Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity1 , 2001, The Journal of Immunology.

[64]  B. Damaj,et al.  Human NK Cells Express CC Chemokine Receptors 4 and 8 and Respond to Thymus and Activation-Regulated Chemokine, Macrophage-Derived Chemokine, and I-3091 , 2000, The Journal of Immunology.

[65]  M. Billah,et al.  The assignment of chemokine‐chemokine receptor pairs: TARC and MIP‐1β are not ligands for human CC‐chemokine receptor 8 , 1999, European journal of immunology.

[66]  A. Mantovani,et al.  Identification of the CC chemokines TARC and macrophage inflammatory protein‐1β as novel functional ligands for the CCR8 receptor , 1998, European journal of immunology.

[67]  O. Yoshie,et al.  The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4* , 1997, The Journal of Biological Chemistry.

[68]  Shuyang Zhang,et al.  Association Between a CCL17 Genetic Variant and Risk of Coronary Artery Disease in a Chinese Han Population. , 2017, Circulation journal : official journal of the Japanese Circulation Society.

[69]  T. Bonner,et al.  Brief Definitive Report Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309 , 2022 .

[70]  R. Steinman,et al.  Brief Definitive Report Identifi Cation of Antigen-presenting Dendritic Cells in Mouse Aorta and Cardiac Valves , 2022 .