Porcine Small Intestine Submucosa for Soft Tissue Augmentation

OBJECTIVE Porcine small intestine submucosa was evaluated as a material for soft tissue augmentation in the hairless guinea pig model. MATERIALS AND METHODS Small intestine submucosa was formed into strips and rolls and implanted into the dorsum of the hairless guinea pig. The animals were divided into three groups and the implants were evaluated grossly and microscopically for persistence, infection, and inflammation. A total of 116 implants were evaluated grossly. RESULTS Selected samples from the 1- and 3-month cohorts and all identifiable samples from the 5-month cohort were evaluated microscopically. Some implants were not located, likely due to migration. With one exception, the identified implants in the 5-month cohort exhibited minimal inflammation and appeared well tolerated. The eight-ply small intestine submucosa material appears well tolerated and provided increased soft tissue volume at 5 months. CONCLUSION Small intestine submucosa may represent an alternative to autologous and homologous materials for soft tissue augmentation.

[1]  M. Gagner,et al.  A Biodegradeable Membrane from Porcine Intestinal Submucosa to Reinforce the Gastrojejunostomy in Laparoscopic Roux-en-Y Gastric Bypass: Preliminary Report , 2001, Obesity surgery.

[2]  Sueki.  Hairless guinea pig skin: anatomical basis for studies of cutaneous biology , 2000, European journal of dermatology : EJD.

[3]  T. Alster,et al.  Human-derived and new synthetic injectable materials for soft-tissue augmentation: current status and role in cosmetic surgery. , 2000, Plastic and reconstructive surgery.

[4]  B. Achauer,et al.  Augmentation of Facial Soft‐Tissue Defects with Alloderm Dermal Graft , 1998, Annals of plastic surgery.

[5]  R. Schuessler,et al.  An experimental model of small intestinal submucosa as a growing vascular graft. , 1998, The Journal of thoracic and cardiovascular surgery.

[6]  S. Badylak,et al.  Identification of extractable growth factors from small intestinal submucosa , 1997, Journal of cellular biochemistry.

[7]  C. Maas,et al.  Complications of Inject able Synthetic Polymers in Facial Augmentation , 1997, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[8]  S. Badylak,et al.  Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment in long-term canine bladder augmentations. , 1996, The Journal of urology.

[9]  W. Larrabee,et al.  Expanded Polytetrafluoroethylene Augmentation of the Lower Face , 1996, The Laryngoscope.

[10]  D. L. Wolf.  Complications following lip augmentation with Gore-Tex. , 1995, Plastic and reconstructive surgery.

[11]  R. Ersek,et al.  Transplantation of Purified Autologous Fat: A 3‐Year Follow‐Up Is Disappointing , 1991, Plastic and reconstructive surgery.

[12]  Rod J. Rohrich,et al.  Early results of vermilion lip augmentation using acellular allogeneic dermis: an adjunct in facial rejuvenation. , 2000, Plastic and reconstructive surgery.

[13]  S. Badylak,et al.  Porcine small intestinal submucosa as a dural substitute. , 1999, Surgical neurology.