Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway
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A. Musarò | A. Paoli | C. Reggiani | L. Larsson | C. Mammucari | R. Rizzuto | P. Muñoz-Cánoves | L. Toniolo | M. Sandri | S. Schiaffino | M. Pende | A. Serrano | A. Maier | C. Meskers | B. Blaauw | G. Pallafacchina | L. Barberi | K. Dyar | A. Bijlsma | V. Romanello | G. Milan | M. Roceri | D. Pion | A. B. Maier | R. Rizzuto | A. Paoli
[1] S. Schiaffino,et al. Role of satellite cells in muscle growth and maintenance of muscle mass. , 2013, Nutrition, metabolism, and cardiovascular diseases : NMCD.
[2] M. Sandri,et al. Mechanisms regulating skeletal muscle growth and atrophy , 2013, The FEBS journal.
[3] Roberto Bottinelli,et al. The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms , 2012, The Journal of physiology.
[4] Peter M. Douglas,et al. RPN-6 determines C. elegans longevity under proteotoxic stress conditions , 2012, Nature.
[5] Eric Ravussin,et al. Skeletal Muscle Mitochondria and Aging: A Review , 2012, Journal of aging research.
[6] James M. Allen,et al. Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin , 2012, The Journal of cell biology.
[7] M. Tarnopolsky,et al. Myostatin is associated with age‐related human muscle stem cell dysfunction , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[8] D. Sabatini,et al. mTOR Signaling in Growth Control and Disease , 2012, Cell.
[9] Dudley Lamming,et al. Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity , 2012, Science.
[10] S. Sze,et al. Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting. , 2011, Molecular endocrinology.
[11] T. Koh,et al. The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice. , 2011, Blood.
[12] I. Ambudkar,et al. Faculty Opinions recommendation of A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. , 2011 .
[13] T. Reynolds,et al. PKB signaling and atrogene expression in skeletal muscle of aged mice. , 2011, Journal of applied physiology.
[14] V. Mootha,et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter , 2011, Nature.
[15] Subhash D. Katewa,et al. Role of TOR signaling in aging and related biological processes in Drosophila melanogaster , 2011, Experimental Gerontology.
[16] C. Mammucari,et al. Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models , 2011, Skeletal Muscle.
[17] N. Perrimon,et al. FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging , 2010, Cell.
[18] C. Kenyon. A pathway that links reproductive status to lifespan in Caenorhabditis elegans , 2010, Annals of the New York Academy of Sciences.
[19] Luca Scorrano,et al. Mitochondrial fission and remodelling contributes to muscle atrophy , 2010, The EMBO journal.
[20] C. Kenyon. The genetics of ageing , 2010, Nature.
[21] L. Partridge,et al. Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster , 2010, Cell metabolism.
[22] L. Schaeffer,et al. Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy , 2009, The Journal of cell biology.
[23] D. Metzger,et al. Autophagy is required to maintain muscle mass. , 2009, Cell metabolism.
[24] C. Reggiani,et al. Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[25] Janet M. Thornton,et al. Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span , 2009, Science.
[26] Marco Pahor,et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.
[27] S. Hatakeyama,et al. Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. , 2009, American journal of physiology. Cell physiology.
[28] C. Mammucari,et al. Smad2 and 3 transcription factors control muscle mass in adulthood. , 2009, American journal of physiology. Cell physiology.
[29] Emanuele Rizzuto,et al. Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1 , 2009, Aging.
[30] C. Reggiani,et al. Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle. , 2008, Human molecular genetics.
[31] Y. Nagamine. Transcriptional regulation of the plasminogen activator inhibitor type 1 – with an emphasis on negative regulation , 2008, Thrombosis and Haemostasis.
[32] E. Casanova,et al. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. , 2008, Cell metabolism.
[33] B. Turk,et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.
[34] A. Goldberg,et al. Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle* , 2008, Journal of Biological Chemistry.
[35] N. LeBrasseur,et al. Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. , 2008, Cell metabolism.
[36] A. Goldberg,et al. FoxO3 controls autophagy in skeletal muscle in vivo. , 2007, Cell metabolism.
[37] J. Petrella,et al. Load-mediated downregulation of myostatin mRNA is not sufficient to promote myofiber hypertrophy in humans: a cluster analysis. , 2007, Journal of applied physiology.
[38] P. Bénit,et al. S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. , 2007, Cell metabolism.
[39] S. Carr,et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. , 2007, Molecular cell.
[40] D. Befroy,et al. Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis , 2007, Cell metabolism.
[41] Nicholas Ling,et al. Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF‐κB‐independent, FoxO1‐dependent mechanism , 2006 .
[42] Jiandie D. Lin,et al. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription , 2006, Proceedings of the National Academy of Sciences.
[43] Jiandie D. Lin,et al. Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators , 2006, Cell.
[44] G. Vogler,et al. Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice , 2006, Mammalian Genome.
[45] P. Muñoz-Cánoves,et al. The plasminogen activation system in skeletal muscle regeneration: antagonistic roles of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1). , 2005, Frontiers in bioscience : a journal and virtual library.
[46] T. Koh,et al. Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration. , 2005, American journal of physiology. Cell physiology.
[47] J. Cross,et al. Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. , 2005, American journal of physiology. Endocrinology and metabolism.
[48] G. Mcclearn,et al. Genetic determinants of weight of fast- and slow-twitch skeletal muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage. , 2005, Physiological genomics.
[49] N. Sonenberg,et al. Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control , 2005, Nature Cell Biology.
[50] N. Rosenthal,et al. Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle. , 2005, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[51] D. Leroith,et al. Skeletal muscle. , 2005, Advances in experimental medicine and biology.
[52] G. Yancopoulos,et al. Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy , 2004, Molecular and Cellular Biology.
[53] Se-Jin Lee. Regulation of muscle mass by myostatin. , 2004, Annual review of cell and developmental biology.
[54] Johan Auwerx,et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[55] I. Gout,et al. The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins , 2004, The Journal of cell biology.
[56] W. Fay. Plasminogen activator inhibitor 1, fibrin, and the vascular response to injury. , 2004, Trends in cardiovascular medicine.
[57] R. DePinho,et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. , 2004, Cancer cell.
[58] Marco Sandri,et al. Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy , 2004, Cell.
[59] G. Mcclearn,et al. Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage. , 2003, Physiological genomics.
[60] K. Inoki,et al. TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.
[61] J. Redondo,et al. Plasminogen activator inhibitor type‐1 inhibits insulin signaling by competing with αvβ3 integrin for vitronectin binding , 2003 .
[62] J. Redondo,et al. Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with alphavbeta3 integrin for vitronectin binding. , 2003, European journal of biochemistry.
[63] J. Blenis,et al. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. , 2002, Molecular cell.
[64] E. Calabria,et al. A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[65] M. Blackman,et al. Comparison of GH, IGF-I, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men. , 2001, American journal of physiology. Endocrinology and metabolism.
[66] C. Rommel,et al. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways , 2001, Nature Cell Biology.
[67] G. Yancopoulos,et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo , 2001, Nature Cell Biology.
[68] Se-Jin Lee,et al. Regulation of myostatin activity and muscle growth , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[69] Antonio Musarò,et al. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle , 2001, Nature Genetics.
[70] D. Leroith,et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[71] J. Escalada,et al. Growth hormone gene expression and secretion in aging rats is age dependent and not age-associated weight increase related. , 1998, Endocrinology.
[72] Se-Jin Lee,et al. Double muscling in cattle due to mutations in the myostatin gene. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[73] S. Lamberts,et al. The endocrinology of aging. , 1997, Science.
[74] Se-Jin Lee,et al. Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member , 1997, nature.
[75] D. Loskutoff,et al. Structural and Functional Analysis of the Plasminogen Activator Inhibitor-1 Binding Motif in the Somatomedin B Domain of Vitronectin* , 1996, The Journal of Biological Chemistry.
[76] Roger M. Nitsch,et al. Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion (*) , 1996, The Journal of Biological Chemistry.
[77] E. Ruoslahti,et al. Association of insulin receptor substrate-1 with integrins. , 1994, Science.
[78] P. Carmeliet,et al. Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. , 1993, The Journal of clinical investigation.
[79] E. Pasquale,et al. The alpha v beta 3 integrin associates with a 190-kDa protein that is phosphorylated on tyrosine in response to platelet-derived growth factor. , 1993, The Journal of biological chemistry.
[80] M. Blackman,et al. Human growth hormone and human aging. , 1993, Endocrine reviews.
[81] N. Rosenthal,et al. A transgene target for positional regulators marks early rostrocaudal specification of myogenic lineages , 1992, Cell.
[82] L. Larsson,et al. Effects of age on physiological, immunohistochemical and biochemical properties of fast‐twitch single motor units in the rat. , 1991, The Journal of physiology.
[83] J. Tobin,et al. The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives. , 1990, Journal of gerontology.
[84] E. Tatum. GENETIC DETERMINANTS , 1964 .