N6-methyladenine modification in noncoding RNAs and its function in cancer

[1]  Xiaohong Wang,et al.  m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis , 2021, Journal of Hematology & Oncology.

[2]  Lijia Ma,et al.  A metabolic labeling method detects m6A transcriptome-wide at single base resolution , 2020, Nature Chemical Biology.

[3]  Yuan Fang,et al.  Circular RNA circ_0000337 contributes to osteosarcoma via the iR-4458/BACH1 pathway. , 2020, Cancer biomarkers : section A of Disease markers.

[4]  M. Yi,et al.  LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma , 2020, Molecular oncology.

[5]  M. Niedoszytko,et al.  MicroRNAs: future biomarkers and targets of therapy in asthma? , 2020, Current opinion in pulmonary medicine.

[6]  Lei Xu,et al.  METTL14 promotes the migration and invasion of breast cancer cells by modulating N6-methyladenosine and hsa-miR-146a-5p expression , 2020, Oncology reports.

[7]  Wei Yan,et al.  m6A-dependent biogenesis of circular RNAs in male germ cells , 2020, Cell Research.

[8]  Yang Wang,et al.  ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma , 2020, Cancer Cell International.

[9]  Z. Ren,et al.  Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway , 2020, Cell proliferation.

[10]  Ok Hyun Park,et al.  Molecular Mechanisms Driving mRNA Degradation by m6A Modification. , 2020, Trends in genetics : TIG.

[11]  Xuehao Wang,et al.  M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma , 2020, Journal of Hematology & Oncology.

[12]  P. Casali,et al.  B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids , 2020, Nature Communications.

[13]  Lixiao Zhou,et al.  N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats , 2020, Nanotoxicology.

[14]  Qian Wang,et al.  Identification of METTL14 in Kidney Renal Clear Cell Carcinoma Using Bioinformatics Analysis , 2019, Disease markers.

[15]  Xiao-ge Hu,et al.  IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader , 2019, Cell Death & Differentiation.

[16]  Hong Wu,et al.  KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3 , 2019, Molecular Cancer.

[17]  Xiaohong Wang,et al.  m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis , 2019, Journal of Hematology & Oncology.

[18]  F. Slack,et al.  The Role of Non-coding RNAs in Oncology , 2019, Cell.

[19]  Jie-Wei Chen,et al.  N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis , 2019, Nature Communications.

[20]  Su Yao,et al.  Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3 , 2019, Molecular Cancer.

[21]  Kate D. Meyer.  DART-seq: an antibody-free method for global m6A detection , 2019, Nature Methods.

[22]  Xin Wen,et al.  Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3. , 2019, Cancer research.

[23]  Yueming Sun,et al.  Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway , 2019, Journal of Experimental & Clinical Cancer Research.

[24]  Yan Wang,et al.  Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stability. , 2019, American journal of translational research.

[25]  Schraga Schwartz,et al.  Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling , 2019, Cell.

[26]  Peijing Zhang,et al.  Non-Coding RNAs and their Integrated Networks , 2019, J. Integr. Bioinform..

[27]  Anthony O. Olarerin-George,et al.  m6A enhances the phase separation potential of mRNA , 2019, Nature.

[28]  Xiaoyu Chen,et al.  The role of m6A RNA methylation in human cancer , 2019, Molecular cancer.

[29]  Shenglong Li,et al.  Circular RNA 0001785 regulates the pathogenesis of osteosarcoma as a ceRNA by sponging miR-1200 to upregulate HOXB2 , 2019, Cell cycle.

[30]  Ok Hyun Park,et al.  Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex. , 2019, Molecular cell.

[31]  Chuan He,et al.  Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. , 2019, Molecular cell.

[32]  Chunjiang He,et al.  The RNA N6-methyladenosine modification landscape of human fetal tissues , 2019, Nature Cell Biology.

[33]  W. Tan,et al.  Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression , 2019, Nature Communications.

[34]  T. Maniatis,et al.  Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice , 2019, Cell.

[35]  D-K Sun,et al.  Up-regulated circular RNA hsa_circ_0067934 contributes to glioblastoma progression through activating PI3K-AKT pathway. , 2019, European review for medical and pharmacological sciences.

[36]  Linjian Xia,et al.  CVm6A: A Visualization and Exploration Database for m6As in Cell Lines , 2019, Cells.

[37]  Kevin C. Wang,et al.  Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments , 2018, Nature Genetics.

[38]  M. Gorospe,et al.  The coding potential of circRNAs , 2018, Aging.

[39]  M. Barna,et al.  The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life. , 2018, Molecular cell.

[40]  Y. Miao,et al.  ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation , 2018, Cellular Physiology and Biochemistry.

[41]  Jenny Hansson,et al.  Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells , 2018, Cell.

[42]  J. Lindberg,et al.  Expression levels of long non-coding RNAs are prognostic for AML outcome , 2018, Journal of Hematology & Oncology.

[43]  Xiaoping Wan,et al.  N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential , 2018, Nucleic acids research.

[44]  Christopher Y. Park,et al.  Meddling with METTLs in Normal and Leukemia Stem Cells. , 2018, Cell stem cell.

[45]  I. Nookaew,et al.  Complete genomic and transcriptional landscape analysis using third-generation sequencing: a case study of Saccharomyces cerevisiae CEN.PK113-7D , 2018, Nucleic acids research.

[46]  James E. Bradner,et al.  R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling , 2018, Cell.

[47]  Samie R. Jaffrey,et al.  Reading m6A in the Transcriptome: m6A-Binding Proteins. , 2017, Trends in cell biology.

[48]  R. Green,et al.  Ribosomopathies: There’s strength in numbers , 2017, Science.

[49]  Yi Xing,et al.  Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs. , 2017, Cell reports.

[50]  M. Mack,et al.  Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome , 2017, The Journal of experimental medicine.

[51]  Yang Xie,et al.  The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention , 2017, Cell.

[52]  U. Weidle,et al.  Long Non-coding RNAs and their Role in Metastasis. , 2017, Cancer genomics & proteomics.

[53]  Chuan He,et al.  m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. , 2017, Cancer cell.

[54]  J. Ule,et al.  Illustrating the Epitranscriptome at Nucleotide Resolution Using Methylation-iCLIP (miCLIP). , 2017, Methods in molecular biology.

[55]  Zhike Lu,et al.  m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells , 2017, Cell reports.

[56]  Yang Zhang,et al.  Extensive translation of circular RNAs driven by N6-methyladenosine , 2017, Cell Research.

[57]  Feng Liu,et al.  METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing , 2017, Hepatology.

[58]  Q. Xue,et al.  MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. , 2017, Biochemical and biophysical research communications.

[59]  Yuan Wang,et al.  MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein* , 2017, The Journal of Biological Chemistry.

[60]  Jie Jin,et al.  FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase. , 2017, Cancer cell.

[61]  Bin Li,et al.  Circular RNAs in cancer: an emerging key player , 2017, Journal of Hematology & Oncology.

[62]  M. Qadir,et al.  miRNA: A Diagnostic and Therapeutic Tool for Pancreatic Cancer. , 2017, Critical reviews in eukaryotic gene expression.

[63]  Samie R. Jaffrey,et al.  m6A RNA methylation promotes XIST-mediated transcriptional repression , 2016, Nature.

[64]  R. Jamal,et al.  Circular RNAs as Promising Biomarkers: A Mini-Review , 2016, Front. Physiol..

[65]  Julia Salzman,et al.  Circular RNAs: analysis, expression and potential functions , 2016, Development.

[66]  Richard A Flavell,et al.  Recent advances in dynamic m6A RNA modification , 2016, Open Biology.

[67]  T. Pan,et al.  N(6)-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding. , 2016, Journal of molecular biology.

[68]  Ling-Ling Chen.  The biogenesis and emerging roles of circular RNAs , 2016, Nature Reviews Molecular Cell Biology.

[69]  Xiao-Qing Yuan,et al.  LncRNAs: key players and novel insights into cervical cancer , 2016, Tumor Biology.

[70]  Howard Y. Chang,et al.  Unique features of long non-coding RNA biogenesis and function , 2015, Nature Reviews Genetics.

[71]  Tingting Zhang,et al.  Long Non Coding RNA MALAT1 Promotes Tumor Growth and Metastasis by inducing Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma , 2015, Scientific Reports.

[72]  Saeed Tavazoie,et al.  HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events , 2015, Cell.

[73]  Gwyn T. Williams,et al.  Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA , 2015, Genes.

[74]  Jiang-xia Zhao,et al.  Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis , 2015, Cell Research.

[75]  Christopher E. Mason,et al.  Single-nucleotide resolution mapping of m6A and m6Am throughout the transcriptome , 2015, Nature Methods.

[76]  Chuan He,et al.  N 6 -methyladenosine Modulates Messenger RNA Translation Efficiency , 2015, Cell.

[77]  S. Tavazoie,et al.  N6-methyladenosine marks primary microRNAs for processing , 2015, Nature.

[78]  Erez Y. Levanon,et al.  m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation , 2015, Science.

[79]  Chuan He,et al.  N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions , 2015, Nature.

[80]  K. Bhat,et al.  EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner , 2015, Stem cell reports.

[81]  Gideon Rechavi,et al.  Gene expression regulation mediated through reversible m6A RNA methylation , 2014, Nature Reviews Genetics.

[82]  Zhike Lu,et al.  m6A-dependent regulation of messenger RNA stability , 2013, Nature.

[83]  Sebastian D. Mackowiak,et al.  Circular RNAs are a large class of animal RNAs with regulatory potency , 2013, Nature.

[84]  J. Kjems,et al.  Natural RNA circles function as efficient microRNA sponges , 2013, Nature.

[85]  Arne Klungland,et al.  ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. , 2013, Molecular cell.

[86]  A. Bhatti,et al.  MicroRNA-155 as a therapeutic target for inflammatory diseases , 2013, Rheumatology International.

[87]  O. Elemento,et al.  Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons , 2012, Cell.

[88]  M. Kupiec,et al.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq , 2012, Nature.

[89]  Y. Li,et al.  FoxM1: a potential drug target for glioma. , 2012, Future oncology.

[90]  J. Rinn,et al.  Modular regulatory principles of large non-coding RNAs , 2012, Nature.

[91]  Chengqi Yi,et al.  N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO , 2011, Nature chemical biology.

[92]  R. Kurokawa,et al.  Promoter-associated long noncoding RNAs repress transcription through a RNA binding protein TLS. , 2011, Advances in experimental medicine and biology.

[93]  Howard Y. Chang,et al.  Long intergenic noncoding RNAs: new links in cancer progression. , 2011, Cancer research.

[94]  Laura Belver,et al.  MicroRNAs prevent the generation of autoreactive antibodies. , 2010, Immunity.

[95]  I. Grummt,et al.  Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. , 2010, Genes & development.

[96]  D. Bartel.  MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[97]  Michael T. McManus,et al.  Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity , 2008, The Journal of experimental medicine.

[98]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[99]  Byoung-Tak Zhang,et al.  Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex , 2006, Cell.

[100]  S. Salzberg,et al.  The Transcriptional Landscape of the Mammalian Genome , 2005, Science.

[101]  R. Shiekhattar,et al.  The Microprocessor complex mediates the genesis of microRNAs , 2004, Nature.

[102]  G. Hannon,et al.  Processing of primary microRNAs by the Microprocessor complex , 2004, Nature.

[103]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[104]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[105]  R. Reenan,et al.  A-to-I Pre-mRNA Editing in Drosophila Is Primarily Involved in Adult Nervous System Function and Integrity , 2000, Cell.

[106]  F. Rottman,et al.  Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. , 1997, RNA.

[107]  H. Sawa,et al.  Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[108]  Y. Shimura,et al.  Association of U6 snRNA with the 5'-splice site region of pre-mRNA in the spliceosome. , 1992, Genes & development.

[109]  B. Maden.  Locations of methyl groups in 28 S rRNA of Xenopus laevis and man. Clustering in the conserved core of molecule. , 1988, Journal of molecular biology.

[110]  G. Sermonti.  The human genome. , 1988, Rivista di biologia.

[111]  J. Gall,et al.  Human Genome Sequencing , 1986, Science.

[112]  B. Maden.  Identification of the locations of the methyl groups in 18 S ribosomal RNA from Xenopus laevis and man. , 1986, Journal of molecular biology.

[113]  J. Gall,et al.  Human genome sequence. , 1986, Science.