Copper-catalyzed highly enantioselective 1,4-conjugate addition of trimethylaluminum to 2-cyclohexenone

Abstract New bidentate phosphites were prepared starting from BINOL and H 8 -BINOL. Utilization of these ligands in the copper-catalyzed enantioselective conjugate addition of trimethylaluminum to 2-cyclohexenone afforded 3-methylcyclohexanone with up to 96% e.e. The scope of this process using various copper sources was investigated.

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