Histamine in lambs with abomasal bloat, haemorrhage and ulcers.

The median concentration of histamine in abomasal fluid of lambs with abomasal haemorrhage and/or ulcers (group 2) was significantly (P < 0.05) higher than the concentrations in lambs presenting abomasal bloat (group 1) and in the healthy and the diseased controls. In group 2, there was also a strong correlation (R2 = 0.81) between the histamine concentrations in abomasal tissue and abomasal fluid, although the median value of histamine in the abomasal tissue was not statistically higher in this group than in the others. The urine of lambs in group 2 also had numerically higher median concentration of histamine than the other groups. Five out of eight tested strains of Lactobacillus spp. and one out of two strains of Clostridium sordellii, isolated from abomasal contents of lambs with abomasal disease, were strong producers of histamine. Bacterial production is one possible source for the increased histamine concentrations in lambs suffering from abomasal haemorrhage and/or ulcers.

[1]  H. Stormorken,et al.  Diet and Histamine in the Ruminant , 1963, Nature.

[2]  O. Sjaastad.  Potentiation by aminoguanidine of the sensitivity of sheep to histamine given by mouth. Effect of amino-guanidine on the urinary excretion of endogenous histamine. , 1967, Quarterly journal of experimental physiology and cognate medical sciences.

[3]  M. Furr,et al.  Treatment of gastric ulcers in horses with histamine type 2 receptor antagonists. , 1989, Equine veterinary journal. Supplement.

[4]  B. Mukerji,et al.  Experimental peptic ulceration. I. The significance of mucous barrier. , 1958, The Indian journal of medical research.

[5]  R. Dubielzig,et al.  Plasma histamine and gastrin concentrations in 17 dogs with mast cell tumors. , 1990, Journal of veterinary internal medicine.

[6]  T. White,et al.  Bioassay of histamine in human urine. An improved method for purification of samples by means of cation exchange chromatography. , 1970, Scandinavian journal of clinical and laboratory investigation.

[7]  P. Romagnoli,et al.  Helicobacter pylori and duodenal ulcer: evidence for a histamine pathways-involving link. , 1996, The American journal of gastroenterology.

[8]  M. Ulvund,et al.  Abomasal bloat, haemorrhage and ulcers in young Norwegian lambs , 2000, Veterinary Record.

[9]  M. Tranulis,et al.  Sarcina -like bacteria, Clostridium fallax and Clostridium sordellii in lambs with abomasal bloat, haemorrhage and ulcers. , 2000, Journal of comparative pathology.

[10]  H. Joosten,et al.  Detection, Growth, and Amine-Producing Capacity of Lactobacilli in Cheese , 1989, Applied and environmental microbiology.