Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
暂无分享,去创建一个
S. Paul | R. Leighty | A. Rojiani | K. Bales | Xin Wu | H. Potter | G. Arendash | Marcos F Garcia | David A. Costa | L. Nilsson | Mark A Low | Jennifer R Cracciolo
[1] S. Wisniewski,et al. Plasma and cerebrospinal fluid α1‐antichymotrypsin levels in Alzheimer's disease: Correlation with cognitive impairment , 2003, Annals of neurology.
[2] L. Mucke,et al. Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid β Peptides But Not on Plaque Formation , 2002, The Journal of Neuroscience.
[3] S. Paul,et al. Apolipoprotein E alters the processing of the β-amyloid precursor protein in APPV717F transgenic mice , 2002, Brain Research.
[4] J. Poirier,et al. Apolipoprotein E knockout mice display procedural deficits in the Morris water maze: analysis of learning strategies in three versions of the task , 2002, Neuroscience.
[5] Markus Rudin,et al. Compromised Hemodynamic Response in Amyloid Precursor Protein Transgenic Mice , 2002, The Journal of Neuroscience.
[6] Bruce J Aronow,et al. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[7] Xin Wu,et al. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model , 2002, Nature Neuroscience.
[8] W. K. Cullen,et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.
[9] A. Fagan,et al. Human and Murine ApoE Markedly Alters Aβ Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer's Disease , 2002, Neurobiology of Disease.
[10] Brett Chromy,et al. Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus , 2002, Brain Research.
[11] Saumya Das,et al. Effect of cytokines, dexamethazone and the A/T-signal peptide polymorphism on the expression of alpha1-antichymotrypsin in astrocytes: significance for Alzheimer's disease , 2001, Neurochemistry International.
[12] H. Potter,et al. The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation , 2001, Neurobiology of Aging.
[13] D. Diamond,et al. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. , 2001, DNA and cell biology.
[14] S. Paul,et al. Neuroinflammation‐induced acceleration of amyloid deposition in the APPV717F transgenic mouse , 2001, The European journal of neuroscience.
[15] M. Sasamata,et al. Apolipoprotein E deposition and astrogliosis are associated with maturation of β-amyloid plaques in βAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer’s disease , 2001, Brain Research.
[16] D. Diamond,et al. Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice , 2001, Neurobiology of Aging.
[17] D. Selkoe. Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.
[18] S. Paul,et al. α-1-Antichymotrypsin Promotes β-Sheet Amyloid Plaque Deposition in a Transgenic Mouse Model of Alzheimer's Disease , 2001, The Journal of Neuroscience.
[19] D. Diamond,et al. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes , 2001, Brain Research.
[20] J. Hardy,et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease , 2000, Nature.
[21] Guiquan Chen,et al. A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease , 2000, Nature.
[22] J. Hardy,et al. Pathways to Primary Neurodegenerative Disease , 2000, Annals of the New York Academy of Sciences.
[23] J. Poirier,et al. Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism , 2000, Annals of the New York Academy of Sciences.
[24] L. Mucke,et al. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. , 2000, The American journal of pathology.
[25] Hsiao-Wen Chen,et al. Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68 , 2000, Nature.
[26] D. Selkoe,et al. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. , 2000, Biochemistry.
[27] K. Ashe,et al. Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease , 2000, The Journal of Neuroscience.
[28] W. Griffin,et al. Interleukin‐1 and the Immunogenetics of Alzheimer Disease , 2000, Journal of neuropathology and experimental neurology.
[29] C. Plata-salamán,et al. Inflammation and Alzheimer’s disease , 2000, Neurobiology of Aging.
[30] A. Fagan,et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[31] J. Dodart,et al. Behavioral deficits in APPV717F transgenic mice decient for the apolipoprotein E gene , 2000, Neuroreport.
[32] S. Paul,et al. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[33] Jim J. Hagan,et al. Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains , 1999, Behavioural Brain Research.
[34] J. Sloane,et al. Metalloendopeptidase EC 3.4.24.15 Is Necessary for Alzheimer’s Amyloid-β Peptide Degradation* , 1999, The Journal of Biological Chemistry.
[35] E. Masliah,et al. Synaptic alterations in apolipoprotein E knockout mice , 1999, Neuroscience.
[36] C. Cahill,et al. Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences* , 1999, The Journal of Biological Chemistry.
[37] J. Gilbert,et al. Specific regional transcription of apolipoprotein E in human brain neurons. , 1999, The American journal of pathology.
[38] C. Lukacs,et al. Alzheimer’s Peptide Aβ1–42 Binds to Two β-Sheets of α1-Antichymotrypsin and Transforms It from Inhibitor to Substrate* , 1998, The Journal of Biological Chemistry.
[39] T. Wisniewski,et al. The prionoses and other conformational disorders. , 1998, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
[40] E. Masliah,et al. Increased levels of α-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype , 1998, Journal of Neuroimmunology.
[41] E. Otomo,et al. Association of α1‐antichymotrypsin polymorphism with cerebral amyloid angiopathy , 1998 .
[42] T. Morgan,et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[43] H. Potter,et al. The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer's disease. , 1998, Frontiers in bioscience : a journal and virtual library.
[44] T. Bliss,et al. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse , 1998, Neuroscience.
[45] S. Paul,et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition , 1997, Nature Genetics.
[46] D. Walsh,et al. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. , 1997, The Journal of biological chemistry.
[47] J. Wehner,et al. Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses , 1997, Neuroscience.
[48] G. Higgins,et al. Absence of central cholinergic deficits in ApoE knockout mice , 1997, Psychopharmacology.
[49] J. Hardy,et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 , 1996, Nature.
[50] J. Rogers,et al. Relative efficacies of amyloid β peptide (Aβ) binding proteins in Aβ aggregation , 1996 .
[51] H. Brewer,et al. Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by Aβ-related peptides , 1996, Neurobiology of Aging.
[52] C. Lukacs,et al. Is the binding of β‐amyloid protein to antichymotrypsin in Alzheimer plaques mediated by a β‐strand insertion? , 1996 .
[53] G. Schellenberg,et al. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.
[54] M. Mullan,et al. β-Amyloid-mediated vasoactivity and vascular endothelial damage , 1996, Nature.
[55] Steven A. Johnson,et al. Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress , 1995, Experimental Neurology.
[56] F. Cohen,et al. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein , 1995, Cell.
[57] M. Ilyas Kamboh,et al. A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism , 1995, Nature Genetics.
[58] A D Roses,et al. Apolipoprotein E and Alzheimer disease. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[59] L. Mucke,et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein , 1995, Nature.
[60] Saumya Das,et al. Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1 , 1995, Neuron.
[61] H. Brewer,et al. Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments , 1994, Nature.
[62] T Vogel,et al. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. , 1994, The American journal of pathology.
[63] A. Roses,et al. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. , 1994, The Journal of clinical investigation.
[64] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[65] M. Pericak-Vance,et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[66] G. Forloni,et al. Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1. , 1992, Brain research. Molecular brain research.
[67] P. Greengard,et al. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[68] B. Cooperman,et al. Crystallization, activity assay and preliminary X-ray diffraction analysis of the uncleaved form of the serpin antichymotrypsin. , 1992, Journal of molecular biology.
[69] Thomas Wisniewski,et al. Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid , 1992, Neuroscience Letters.
[70] E. Otomo,et al. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease , 1991, Brain Research.
[71] P. Mcgeer,et al. Anti-inflammatory drugs and Alzheimer disease , 1990, The Lancet.
[72] H. W. Harris,et al. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[73] D. Selkoe,et al. Immunochemical identification of the serine protease inhibitor α 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease , 1988, Cell.
[74] R. Morris,et al. Place navigation impaired in rats with hippocampal lesions , 1982, Nature.
[75] D. Price,et al. Mutant genes in familial Alzheimer's disease and transgenic models. , 1998, Annual review of neuroscience.
[76] Peter T. Lansbury,et al. Observation of metastable Aβ amyloid protofibrils by atomic force microscopy , 1997 .