Tissue Engineering and Regenerative Medicine in Iran: Current State of Research and Future Outlook

During two decades ago, Iran has exhibited remarkable increase in scientific publication in different aspects including tissue engineering and regenerative medicine (TERM). The field of TERM in Iran dates comes back to the early part of the 1990 and the advent of stem cell researches. Nowadays, Iran is one of the privileged countries in stem cell therapy in the Middle East. The next major milestone in TERM was application and fabrication of scaffolds for tissue engineering in the early 2000s with a focus on engineering bone and cartilage tissue. A good amount of thoughtful works has also yielded prototypes of other tissue substitutes such as nerve conduits, liver, and even heart. However, forward movement to clinical application of these products is still far from offering clinically acceptable solutions. In this study, we have presented a comprehensive review on the efforts of Iranian scientists in different issues of tissue engineering and regenerative medicine field.

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[60]  M. Soleimani,et al.  Stem cell‐conditioned medium does not protect against kidney failure , 2011, Cell biology international.

[61]  E. Biazar,et al.  A nanofibrous PHBV tube with Schwann cell as artificial nerve graft contributing to Rat sciatic nerve regeneration across a 30-mm defect bridge , 2013, Cell communication & adhesion.

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[76]  M. Akhondi,et al.  Comparative Evaluation of Cardiac Markers in Differentiated Cells from Menstrual Blood and Bone Marrow-Derived Stem Cells In Vitro , 2014, Molecular Biotechnology.

[77]  M. Soleimani,et al.  Neural differentiation of mouse embryonic stem cells on conductive nanofiber scaffolds , 2012, Biotechnology Letters.

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[87]  M. Sahraian,et al.  Autologous mesenchymal stem cell therapy in progressive multiple sclerosis: an open label study. , 2012, Current stem cell research & therapy.

[88]  J. Ai,et al.  Three‐dimensional culture of differentiated endometrial stromal cells to oligodendrocyte progenitor cells (OPCs) in fibrin hydrogel , 2013, Cell biology international.

[89]  H. Shahriari,et al.  Comparison of the Effect of Amniotic Membrane Suspension and Autologous Serum on Alkaline Corneal Epithelial Wound Healing in the Rabbit Model , 2008, Cornea.

[90]  J. Hilborn,et al.  One-stage tissue engineering of bladder wall patches for an easy-to-use approach at the surgical table. , 2013, Tissue engineering. Part C, Methods.

[91]  S. Shirian,et al.  Evaluation of Motor Neuron-Like Cell Differentiation of hEnSCs on Biodegradable PLGA Nanofiber Scaffolds , 2014, Molecular Neurobiology.

[92]  S. Nematollahi-Mahani,et al.  Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients , 2012, Clinical Neurology and Neurosurgery.

[93]  F. Sarrafzadeh-Rezaei,et al.  Enhanced mechanical properties of rabbit flexor tendons in response to intratendinous injection of adipose derived stromal vascular fraction. , 2012, Current stem cell research & therapy.

[94]  A. Oryan,et al.  Human platelet rich plasma plus Persian Gulf coral effects on experimental bone healing in rabbit model: radiological, histological, macroscopical and biomechanical evaluation , 2012, Journal of Materials Science: Materials in Medicine.

[95]  H. Baharvand,et al.  Effect of basic fibroblast growth factor on cardiomyocyte differentiation from mouse embryonic stem cells. , 2007, Saudi medical journal.

[96]  M. Nasr-Esfahani,et al.  Differentiation of human embryonic stem cell-derived retinal progenitors into retinal cells by Sonic hedgehog and/or retinal pigmented epithelium and transplantation into the subretinal space of sodium iodate-injected rabbits. , 2012, Stem cells and development.

[97]  M. Soleimani,et al.  Effects of TGF-β and b-FGF on the Potential of Peripheral Blood-Borne Stem Cells and Bone Marrow-Derived Stem Cells in Wound Healing in a Murine Model , 2011, Inflammation.

[98]  A. Baradaran-rafii,et al.  Limbal Stem Cell–Sparing Lamellar Keratoplasty for the Management of Advanced Keratoglobus , 2014, Cornea.

[99]  M. Hosseini,et al.  Neuroprotective effects of mesenchymal stem cell transplantation in animal model of cerebellar degeneration , 2011, Neurological research.

[100]  E. Biazar,et al.  The healing effect of stem cells loaded in nanofibrous scaffolds on full thickness skin defects. , 2013, Journal of biomedical nanotechnology.

[101]  Azita Tehranchi,et al.  Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: a preliminary report. , 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[102]  M. Shokrgozar,et al.  Transplantation of schwann cells differentiated from adipose stem cells improves functional recovery in rat spinal cord injury. , 2013, Archives of Iranian medicine.

[103]  S. Shakeri,et al.  Application of amniotic membrane as xenograft for urethroplasty in rabbit , 2009, International Urology and Nephrology.

[104]  M. Soleimani,et al.  Mechanical characteristics of electrospun aligned PCL/PLLA nanofibrous scaffolds conduct cell differentiation in human bladder tissue engineering. , 2013, Journal of nanoscience and nanotechnology.

[105]  H. Baharvand,et al.  Dehydroepiandrosterone stimulates neurogenesis in mouse embryonal carcinoma cell- and human embryonic stem cell-derived neural progenitors and induces dopaminergic neurons. , 2010, Stem cells and development.

[106]  M. Fathi,et al.  In vitro corrosion behavior of bioceramic, metallic, and bioceramic-metallic coated stainless steel dental implants. , 2003, Dental materials : official publication of the Academy of Dental Materials.

[107]  H. Baharvand,et al.  Intraepidermal injection of dissociated epidermal cell suspension improves vitiligo , 2010, Archives of Dermatological Research.

[108]  H. Namazi,et al.  A novel use of amniotic membrane for fingertip injuries. , 2014, Journal of wound care.

[109]  H. Baharvand,et al.  Generation of insulin‐secreting cells from human embryonic stem cells , 2006, Development, growth & differentiation.

[110]  H. Baharvand,et al.  Safety and efficacy of granulocyte-colony-stimulating factor administration following autologous intramuscular implantation of bone marrow mononuclear cells: a randomized controlled trial in patients with advanced lower limb ischemia. , 2010, Cytotherapy.

[111]  S. Homaeigohar,et al.  The effect of partially stabilized zirconia on the mechanical properties of the hydroxyapatite–polyethylene composites , 2004, Journal of materials science. Materials in medicine.

[112]  M. Nasr-Esfahani,et al.  Functional expression of potassium channels in cardiomyocytes derived from embryonic stem cells , 2012, Research in pharmaceutical sciences.

[113]  M. Soleimani,et al.  Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I–II clinical trial , 2009, European journal of gastroenterology & hepatology.

[114]  H. Baharvand,et al.  Electrospun nanofibrillar surfaces promote neuronal differentiation and function from human embryonic stem cells. , 2011, Tissue engineering. Part A.

[115]  M. Behmanesh,et al.  Pancreatic islet differentiation of human embryonic stem cells by microRNA overexpression , 2016, Journal of tissue engineering and regenerative medicine.

[116]  A. Lode,et al.  Fabrication and characterization of regenerated silk scaffolds reinforced with natural silk fibers for bone tissue engineering. , 2013, Journal of biomedical materials research. Part A.

[117]  F. Moulavi,et al.  Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation* , 2011, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[118]  B. Hashemibeni,et al.  An animal model study for repair of tracheal defects with autologous stem cells and differentiated chondrocytes from adipose-derived stem cells. , 2012, Journal of pediatric surgery.

[119]  Ali Samadikuchaksaraei,et al.  High-tech biomedical research: lessons from Iran's experience , 2008, Biomedical engineering online.

[120]  S. Mowla,et al.  p75NTR suppression in rat bone marrow stromal stem cells significantly reduced their rate of apoptosis during neural differentiation , 2011, Neuroscience Letters.

[121]  M. Prabhakaran,et al.  Development of nanofibrous cellulose acetate/gelatin skin substitutes for variety wound treatment applications , 2014, Journal of biomaterials applications.

[122]  M. Soleimani,et al.  Characterization and Chondrogenic Differentiation of Menstrual Blood-Derived Stem Cells on a Nanofibrous Scaffold , 2012, The International journal of artificial organs.

[123]  H. Baharvand,et al.  Effect of poly-L-lysine coating on retinoic acid-loaded PLGA microspheres in the differentiation of carcinoma stem cells into neural cells. , 2010, The International journal of artificial organs.

[124]  B. Khademi,et al.  Differentiation of adipose-derived stem cells into ear auricle cartilage in rabbits , 2012, The Journal of Laryngology & Otology.

[125]  A. Oryan,et al.  Bone tissue engineering with periosteal‐free graft and pedicle omentum , 2013, ANZ journal of surgery.

[126]  A. Meimandi-Parizi,et al.  Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance , 2013, Journal of Biomedical Science.

[127]  S. Nematollahi-Mahani,et al.  Improvement in Cardiac Function following Transplantation of Human Umbilical Cord Matrix-Derived Mesenchymal Cells , 2011, Cardiology.

[128]  M. Jeddi-Tehrani,et al.  Osteogenic differentiation of stem cells derived from menstrual blood versus bone marrow in the presence of human platelet releasate. , 2012, Tissue engineering. Part A.

[129]  A. Ahani,et al.  Comparative Evaluation of Differentiation Potential of Menstrual Blood- Versus Bone Marrow- Derived Stem Cells into Hepatocyte-Like Cells , 2014, PloS one.

[130]  M. Mozafari,et al.  Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering , 2012, International journal of nanomedicine.

[131]  A. Meimandi-Parizi,et al.  Implantation of a novel tissue-engineered graft in a large tendon defect initiated inflammation, accelerated fibroplasia and improved remodeling of the new Achilles tendon: a comprehensive detailed study with new insights , 2013, Cell and Tissue Research.

[132]  Theo M de Reijke,et al.  Propagation of human spermatogonial stem cells in vitro. , 2009, JAMA.

[133]  Mohammad Ali Sahraian,et al.  Evaluation of cytokines in multiple sclerosis patients treated with mesenchymal stem cells. , 2013, Archives of medical research.

[134]  Hossein Baharvand,et al.  Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord. , 2009, Cytotherapy.

[135]  E. Biazar,et al.  The healing effect of unrestricted somatic stem cells loaded in collagen-modified nanofibrous PHBV scaffold on full-thickness skin defects , 2014, Artificial cells, nanomedicine, and biotechnology.

[136]  H. Salour,et al.  Two-Stage Procedure for Management of Large Exposure Defects of Hydroxyapatite Orbital Implant , 2003, European journal of ophthalmology.

[137]  M. Ayaz.  An approach to 'use of split-thickness plantar skin grafts in the treatment of hyperpigmented skin-grafted fingers and palms in previously burned patients'. , 2013, Burns : journal of the International Society for Burn Injuries.

[138]  C. V. van Blitterswijk,et al.  Fabrication, Characterization and Cellular Compatibility of Poly(Hydroxy Alkanoate) Composite Nanofibrous Scaffolds for Nerve Tissue Engineering , 2013, PloS one.

[139]  K. Parivar,et al.  Functionalisation and surface modification of electrospun polylactic acid scaffold for tissue engineering , 2014, Cell biology international.

[140]  R. Malekzadeh,et al.  Autologous transplantation of bone marrow-derived mononuclear and CD133(+) cells in patients with decompensated cirrhosis. , 2011, Archives of Iranian medicine.

[141]  S. Razavi,et al.  Stability of neural differentiation in human adipose derived stem cells by two induction protocols. , 2012, Tissue & cell.

[142]  H. Baharvand,et al.  Differentiation of Bone Marrow-derived Mesenchymal Stem Cells into Hepatocyte-like Cells on Nanofibers and Their Transplantation into a Carbon Tetrachloride-Induced Liver Fibrosis Model , 2011, Stem Cell Reviews and Reports.

[143]  Isolation and enrichment of defined neural cell populations from heterogeneous neural stem cell progeny. , 2013, Methods in molecular biology.

[144]  N. Maffulli,et al.  Implantation of a novel biologic and hybridized tissue engineered bioimplant in large tendon defect: an in vivo investigation. , 2013, Tissue engineering. Part A.

[145]  I. Silver,et al.  Effectiveness of hybridized nano‐ and microstructure biodegradable, biocompatible, collagen‐based, three‐dimensional bioimplants in repair of a large tendon‐defect model in rabbits , 2016, Journal of tissue engineering and regenerative medicine.

[146]  L. Bahmani,et al.  Coculture with embryonic stem cells improves neural differentiation of adipose tissue-derived stem cells , 2014, Neuroscience.

[147]  Masoud Latifi,et al.  The influence of surface nanoroughness of electrospun PLGA nanofibrous scaffold on nerve cell adhesion and proliferation , 2013, Journal of Materials Science: Materials in Medicine.

[148]  M. Rajabi,et al.  Bandage Contact Lens and Topical Indomethacin for Treating Persistent Corneal Epithelial Defects After Vitreoretinal Surgery , 2007, Cornea.

[149]  A. Oryan,et al.  Wrapped omentum with periosteum concurrent with adipose derived adult stem cells for bone tissue engineering in dog model , 2014, Cell and Tissue Banking.

[150]  M. Soleimani,et al.  In vitro cardiomyogenic potential of human umbilical vein-derived mesenchymal stem cells. , 2006, Biochemical and biophysical research communications.

[151]  H. Baharvand,et al.  ISL1 Protein Transduction Promotes Cardiomyocyte Differentiation from Human Embryonic Stem Cells , 2013, PloS one.

[152]  M. Dodel,et al.  Evaluation of the Effect of NT-3 and Biodegradable Poly-l-lactic Acid Nanofiber Scaffolds on Differentiation of Rat Hair Follicle Stem Cells into Neural Cells In Vitro , 2013, Journal of Molecular Neuroscience.

[153]  H. Baharvand,et al.  Therapeutic Potential of Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Mice with Lethal Fulminant Hepatic Failure , 2013, Cell transplantation.

[154]  N. Sarrafzadegan,et al.  Incidence of cardiovascular diseases in an Iranian population: the Isfahan Cohort Study. , 2013, Archives of Iranian medicine.

[155]  Hossein Baharvand,et al.  Differentiation of Embryonic Stem Cells into Neural Cells on 3D Poly (D, L-Lactic Acid) Scaffolds versus 2D Cultures , 2011, The International journal of artificial organs.

[156]  S. Bahrami,et al.  Effect of tissue-engineered chitosan-poly(vinyl alcohol) nanofibrous scaffolds on healing of burn wounds of rat skin. , 2012, IET nanobiotechnology.

[157]  M. Soleimani,et al.  Sinus augmentation using human mesenchymal stem cells loaded into a beta-tricalcium phosphate/hydroxyapatite scaffold. , 2008, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[158]  M. Shokrgozar,et al.  Composite bone substitute materials based on β-tricalcium phosphate and magnesium-containing sol–gel derived bioactive glass , 2009, Journal of materials science. Materials in medicine.

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