论文信息 - Action of Guanethidine on the 5‐Hydroxytryptamine Content of the Brain

Action of Guanethidine on the 5‐Hydroxytryptamine Content of the Brain

Action of Guanethidine on the 5-Hydrorrytryptamine Content of the Brain Sm,-As guanethidine decreases the level of noradrenaline in the brain of the rat (FTeifer, Vizi and Story, 1962; Kroneberg and Schiirnam, 1962), it seemed interesting to us to investigate the effect of guanethidine on the 5-hydroxytryptamine (5-HT) content of the brain. In addition we compared a-methyldopa (an inhibitor of 5-hydroxytryptophan decarboxylase) and reserpine with guanethidine. White rats of both sexes and of different ages were used. Brain 5-HT content was estimated by the procedure described by Bertaccini (1960). Guanethidine, DL-a-methyldopa and reserpine were administered once daily for 7 or 12 days. Animals were killed 16-24 hr. after the last drug administration.

R. Ferrini | A. Glaesser

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