Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats

Vimang is an aqueous extract of Mangifera indica L, used in Cuba for the treatment of immunopathological disorders. Increasing evidence from preclinical studies indicates that Vimang displays antioxidant, antiallergic, analgesic and antiinflammatory actions. The present study investigated the effects of systemic administration of Vimang on behavioural outcomes of neurological function in rats. A single oral administration of Vimang produced an impairment of short‐ and long‐term retention of memory for aversive training when given either 1 h pretraining or immediately posttraining, but not 8 h posttraining. Vimang did not affect open field behaviour or habituation. The results indicate that Vimang might induce deficits of emotionally motivated memory without affecting nonassociative memory, locomotion, exploratory behaviour or anxiety. Copyright © 2008 John Wiley & Sons, Ltd.

[1]  A. Vercesi,et al.  Mangifera indica L. extract (Vimang) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse. , 2008, Pharmacological research.

[2]  Mariela Guevara-García,et al.  The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract. , 2007, Pharmacological research.

[3]  R. Delgado,et al.  Interaction of Vimang (Mangifera indica L. extract) with Fe(III) improves its antioxidant and cytoprotecting activity. , 2006, Pharmacological research.

[4]  A. Vercesi,et al.  Dual mechanism of mangiferin protection against iron-induced damage to 2-deoxyribose and ascorbate oxidation. , 2006, Pharmacological research.

[5]  S. Cuzzocrea,et al.  Anti‐allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin , 2006, The Journal of pharmacy and pharmacology.

[6]  A. Vercesi,et al.  Mangifera indica L. extract (Vimang®) inhibits 2‐deoxyribose damage induced by Fe (III) plus ascorbate , 2006, Phytotherapy research : PTR.

[7]  A. Vercesi,et al.  Vimang (Mangifera indica L. extract) induces permeability transition in isolated mitochondria, closely reproducing the effect of mangiferin, Vimang's main component. , 2006, Chemico-biological interactions.

[8]  R. Roesler,et al.  Non-associative learning and anxiety in rats treated with a single systemic administration of the gastrin-releasing peptide receptor antagonist RC-3095 , 2005, Peptides.

[9]  A. Vercesi,et al.  Mangifera indica L. extract (Vimang) inhibits Fe2+-citrate-induced lipoperoxidation in isolated rat liver mitochondria. , 2005, Pharmacological research.

[10]  M. Blanco-Molina,et al.  An aqueous stem bark extract of Mangifera indica (Vimang®) inhibits T cell proliferation and TNF‐induced activation of nuclear transcription factor NF‐κB , 2005, Phytotherapy research : PTR.

[11]  I. Izquierdo,et al.  Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats , 2004, Behavioural Brain Research.

[12]  A. Nuñez,et al.  Vascular effects of the Mangifera indica L. extract (Vimang). , 2004, European journal of pharmacology.

[13]  J. Leiro,et al.  An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages. , 2004, International immunopharmacology.

[14]  G. Garrido,et al.  Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG). Role of mangiferin isolated from the extract. , 2004, Pharmacological research.

[15]  R. Roesler,et al.  RC-3095, a bombesin/gastrin-releasing peptide receptor antagonist, impairs aversive but not recognition memory in rats. , 2004, European journal of pharmacology.

[16]  F. Ubeira,et al.  Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin , 2003, Phytotherapy research : PTR.

[17]  F. Ubeira,et al.  Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses , 2003, Phytotherapy research : PTR.

[18]  R. Roesler,et al.  Differential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in rats , 2003, Brain Research.

[19]  I. A. Ross,et al.  Mangifera indica L. , 2003 .

[20]  L. Re,et al.  Protective effect of Mangifera indica L. extract (Vimang®) on the injury associated with hepatic ischaemia reperfusion , 2003, Phytotherapy research : PTR.

[21]  I. Izquierdo,et al.  Differential neurobehavioral deficits induced by apomorphine and its oxidation product, 8-oxo-apomorphine-semiquinone, in rats. , 2002, European journal of pharmacology.

[22]  F. Ubeira,et al.  Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin. , 2002, International immunopharmacology.

[23]  L. Rastrelli,et al.  Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement. , 2002, Journal of agricultural and food chemistry.

[24]  G. Garrido,et al.  Analgesic and anti‐inflammatory effects of Mangifera indica L. extract (Vimang) , 2001, Phytotherapy research : PTR.

[25]  O. S. León-Fernández,et al.  Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. , 2000, Pharmacological research.

[26]  G. Garrido,et al.  Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang) , 2000, Phytotherapy research : PTR.

[27]  R. Delgado,et al.  Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rat serum and liver. , 2008, Pharmacological research.

[28]  C. Viada,et al.  Mangifera indica L. (Vimang) protection against serum oxidative stress in elderly humans. , 2006, Archives of medical research.

[29]  G. Garrido,et al.  In vivo and in vitro anti-inflammatory activity of , 2022 .