This paper estimates the static strength of a certain type of cooling fan designed by a company in the rotating speed of 1260 rpm and 1380 rpm, evaluates static strength according to the cooling fan’s permissible stress in F state and T1 state, estimates the fatigue strength according to the operation load of cooling fan suffering from different direction when locomotive running and evaluates the cooling fan fatigue life according to the IIW standard. Static strength and fatigue strength calculation using ANSYS companies in the United States commercial version of the ANSYS software to complete.