Transfusion of 35‐day stored red blood cells does not result in increase of plasma non‐transferrin bound iron in human endotoxemia

Transfusion of a single unit of stored red blood cells (RBCs) has been hypothesized to induce supra‐physiological levels of non‐transferrin bound iron (NTBI), which may enhance inflammation and act as a nutrient for bacteria. We investigated the relation between RBC storage time and iron levels in a clinically relevant “two‐hit” human transfusion model.

[1]  I. Papassideri,et al.  Donor‐variation effect on red blood cell storage lesion: A close relationship emerges , 2016, Proteomics. Clinical applications.

[2]  R. Lutter,et al.  Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans* , 2016, Critical care medicine.

[3]  A. Forster,et al.  Effect of Blood Donor Characteristics on Transfusion Outcomes: A Systematic Review and Meta-Analysis. , 2016, Transfusion medicine reviews.

[4]  C. Natanson,et al.  In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome , 2015, Transfusion.

[5]  S. Sheth,et al.  Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children , 2015, American journal of hematology.

[6]  S. Assmann,et al.  Effects of red-cell storage duration on patients undergoing cardiac surgery. , 2015, The New England journal of medicine.

[7]  Jeannie Callum,et al.  Age of transfused blood in critically ill adults. , 2015, The New England journal of medicine.

[8]  J. Wetterslev,et al.  Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis , 2015, BMJ : British Medical Journal.

[9]  S. Spitalnik,et al.  Stored red blood cell transfusions: iron, inflammation, immunity, and infection , 2014, Transfusion.

[10]  M. Gladwin,et al.  Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia , 2014, Transfusion.

[11]  J. Hess.  Measures of stored red blood cell quality , 2014, Vox sanguinis.

[12]  K. Collard,et al.  The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units. , 2014, Blood transfusion = Trasfusione del sangue.

[13]  M. Gladwin,et al.  Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. , 2014, Blood.

[14]  E. Hod,et al.  Transfusion of 28‐day‐old leucoreduced or non‐leucoreduced stored red blood cells induces an inflammatory response in healthy dogs , 2013, Vox sanguinis.

[15]  M. Stark,et al.  Does non-transferrin bound iron contribute to transfusion related immune-modulation in preterms? , 2013, Archives of Disease in Childhood: Fetal and Neonatal Edition.

[16]  S. Sheth,et al.  Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron. , 2011, Blood.

[17]  Ning Zhang,et al.  Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. , 2010, Blood.

[18]  Tatsuro Yoshida,et al.  Anaerobic storage of red blood cells in a novel additive solution improves in vivo recovery , 2009, Transfusion.

[19]  P. Marik,et al.  Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature* , 2008, Critical care medicine.

[20]  W. D. de Grip,et al.  Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods , 2008, Transfusion.

[21]  J. AuBuchon,et al.  Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials , 2008, Transfusion.

[22]  A. Cross,et al.  Review: From therapy to experimental model: a hundred years of endotoxin administration to human subjects , 2007, Journal of endotoxin research.

[23]  D. Fergusson,et al.  Clinical consequences of red cell storage in the critically ill , 2006, Transfusion.

[24]  G. Bosman,et al.  Survival of the fittest?--survival of stored red blood cells after transfusion. , 2004, Cellular and molecular biology.

[25]  V. Kretschmer,et al.  Flow-Cytometric Determination of Survival Time and 24-Hour Recovery of Transfused Red Blood Cells , 2003, Transfusion Medicine and Hemotherapy.

[26]  G. Wells,et al.  A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. , 1999, The New England journal of medicine.

[27]  T. Yasuda,et al.  An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum. , 1995, Biochemistry and molecular biology international.