Comparative chemical analyses of drug samples: general approach and application to heroin.

The methodology used for the comparative chemical analyses of illicit drug seizures, and its application to a heroin comparison case, is described. The illicit drug sample is subjected to a three-step procedure. The first is the qualitative and quantitative analysis of each sample, i.e. identification and quantitation of major and minor constituents. The second is the analysis of trace level impurities contained in each sample, after isolation from the drug matrix. The last step is the isotopic analysis of each sample, i.e. the determination of the isotopic enrichment of the major constituents. That analytical procedure, applied to heroin, allowed the determination of common batch samples with a high degree of certainty.

[1]  Verweij Am.  Impurities in Illicit Drug Preparations: Amphetamine and Methamphetamine. , 1989 .

[2]  Possible characterization of samples of Cannabis sativa l. by their carbon isotopic distributions. , 1979, Journal of forensic sciences.

[3]  John F. Casale,et al.  A Chromatographic Impurity Signature Profile Analysis for Cocaine Using Capillary Gas Chromatography , 1991 .

[4]  F. Medina.  The Identification of Heroin and Three Structurally Related Isoheroins , 1989 .

[5]  I. Lurie,et al.  Isolation, identification and separation of isomeric truxillines in illicit cocaine , 1990 .

[6]  M. Chiarotti,et al.  HPLC analysis of cocaine diastereoisomers by chiral stationary phase , 1990 .

[7]  S. A. Angelos,et al.  The Identification of Unreacted Precursors, Impurities, and By-Products in Clandestinely Produced Phencyclidine Preparations , 1990 .

[8]  Takako Inoue,et al.  Impurity Profiling Analysis of Illicit Methamphetamine by Capillary Gas Chromatography , 1994 .

[9]  Lisa M. Brewer,et al.  N -Formyl Cocaine: A Study of Cocaine Comparison Parameters , 1991 .

[10]  H. Urey,et al.  Improvements in mass spectrometers for the measurement of small differences in isotope abundance ratios. , 1950, The Review of scientific instruments.

[11]  D. A. Cooper,et al.  Illicit heroin manufacturing byproducts: capillary gas chromatographic determination and structural elucidation of narcotine- and norlaudanosine-related compounds. , 1984, Analytical chemistry.

[12]  Helmut Neumann.  Comparison of heroin by capillary gas chromatography in Germany , 1994 .

[13]  K. Himberg,et al.  Automated gas chromatographic amphetamine profiling , 1994 .

[14]  K. Mcguinness,et al.  The Quantitation of Heroin and Selected Basic Impurities via Reversed Phase HPLC. II. The Analysis of Adulterated Samples , 1986 .

[15]  K E Janzen,et al.  Comparison analysis of illicit cocaine samples. , 1992, Journal of forensic sciences.

[16]  J. Hummelen,et al.  Isolation, Identification, and Origin of Three Previously Unknown Congeners in Illicit Cocaine , 1991 .

[17]  James R. Pearson,et al.  Impurity profiling of methylamphetamine in Australia and the development of a national drugs database , 1994 .

[18]  R. D. Zeeuw,et al.  Detection, Isolation, and Identification of Truxillines in Illicit Cocaine by Means of Thin-Layer Chromatography and Mass Spectrometry , 1991 .

[19]  S. Seta,et al.  Impurity profiling analysis of methamphetamine seized in Japan , 1994 .

[20]  L. King,et al.  Amphetamine profiling in the UK , 1994 .

[21]  J. Casale.  Detection of pseudoecgonine and differentiation from ecgonine in illicit cocaine , 1990 .

[22]  Benjamin A. Perillo,et al.  Recent advances by the U.S. Drug Enforcement Administration in drug signature and comparative analysis , 1994 .

[23]  R. P. Meyers,et al.  The anatomy of a cocaine comparison case: a prosecutorial and chemistry perspective. , 1993, Journal of forensic sciences.

[24]  F. Besacier,et al.  Isotopic Analysis of13C as a Tool for Comparison and Origin Assignment of Seized Heroin Samples , 1997 .

[25]  R. D. de Zeeuw,et al.  A rapid gas chromatographic method for the fingerprinting of illicit cocaine samples. , 1992, Journal of forensic sciences.

[26]  C.S.L. Jonson,et al.  Amphetamine profiling — improvements of data processing , 1994 .

[27]  D. A. Cooper,et al.  Determination of neutral manufacturing impurities in heroin by capillary gas chromatography with electron capture detection after reduction with lithium aluminum hydride and derivatization with heptafluorobutyric anhydride. , 1986, Analytical chemistry.

[28]  D. A. Cooper,et al.  The application of capillary gas chromatography-electron capture detection in the comparative analyses of illicit cocaine samples. , 1993, Journal of forensic sciences.

[29]  A. Veltkamp,et al.  Determination of ‘common-batch’ members in a set of confiscated 3,4-(methylendioxy)-methylamphetamine samples by measuring the natural isotope abundances: a preliminary study , 1995 .

[30]  M. Lebelle,et al.  Comparison of Illicit Cocaine by Determination of Minor Components , 1991 .

[31]  D. Massart.  Chemometrics: A Textbook , 1988 .