Acute Lymphoblastic Leukemia With Pre-B-CelI Characteristics

Blast cells from 6 of 50 patients with acute are probably related to early B-cell precurlymphoblastic leukemia (ALL) displayed sors (pre-B cells). In 4 of 6 cases the intracytoplasmic g chains in the absence of disease had a tumoral presentation; the detectable light chains and surface immuprognostic significance of this new subnoglobulins. These cells also expressed Iagroup. which accounts for 20% of patients like and common ALL antigens. Terminal with non-T non-B ALL. remains to be deoxynucleotidyltransferase was detectestablished. able in 2 of 5 cases tested. These blast cells

[1]  J. Brouet,et al.  The immunological classification of acute lymphoblastic leukemias , 1978, Cancer.

[2]  M. Cooper,et al.  Pre-B-cell leukemia. A new phenotype of childhood lymphoblastic leukemia. , 1978, The New England journal of medicine.

[3]  M. Cooper,et al.  B lymphocyte precursors in human bone marrow: an analysis of normal individuals and patients with antibody-deficiency states. , 1978, Journal of immunology.

[4]  M. Cooper,et al.  Immunofluorescent studies of the development of pre‐B cells, B lymphocytes and immunoglobulin isotype diversity in humans , 1977, European journal of immunology.

[5]  D. Baltimore,et al.  Terminal deoxynucleotidyl transferase is found in prothymocytes , 1976, The Journal of experimental medicine.

[6]  G. Flandrin,et al.  Immunological Classification of Acute Lymphoblastic Leukaemias: Evaluation of its Clinical Significance in a Hundred Patients , 1976, British journal of haematology.

[7]  J. Strominger,et al.  Distribution of Ia-like molecules on the surface of normal and leukemic human cells. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[8]  M. Greaves,et al.  Leukemia-associated antigens in man. , 1975, Journal of the National Cancer Institute.

[9]  D. Baltimore.  Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes? , 1974, Nature.

[10]  L. Chang,et al.  Development of terminal deoxynucleotidyl transferase activity in embryonic calf thymus gland. , 1971, Biochemical and biophysical research communications.