A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions.

[1]  J. Kissil,et al.  Merlin in organ size control and tumorigenesis: Hippo versus EGFR? , 2010, Genes & development.

[2]  M. Giovannini,et al.  Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. , 2010, Genes & development.

[3]  S. Baader,et al.  Merlin Inhibits Neurite Outgrowth in the CNS , 2010, The Journal of Neuroscience.

[4]  M. Giovannini,et al.  The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. , 2010, Developmental cell.

[5]  R. Jain,et al.  Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. , 2010, Cancer research.

[6]  Jonathan A. Cooper,et al.  Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus , 2010, Cell.

[7]  Gurpreet W. Tang,et al.  Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes , 2009, Nature.

[8]  R. Hennigan,et al.  Fluorescence Resonance Energy Transfer Analysis of Merlin Conformational Changes , 2009, Molecular and Cellular Biology.

[9]  A. McClatchey,et al.  Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma , 2009, Proceedings of the National Academy of Sciences.

[10]  F. Chareyre,et al.  Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas , 2009, Oncogene.

[11]  P. Lécine,et al.  The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. , 2009, Blood.

[12]  John G. Collard,et al.  Crosstalk between small GTPases and polarity proteins in cell polarization , 2008, Nature Reviews Molecular Cell Biology.

[13]  M. Yaffe,et al.  Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. , 2008, Cancer research.

[14]  Sylwia Ammoun,et al.  Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma. , 2008, Cancer research.

[15]  Carola Förster,et al.  Tight junctions and the modulation of barrier function in disease , 2008, Histochemistry and Cell Biology.

[16]  L. Holmgren,et al.  Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells. , 2008, Biochimica et biophysica acta.

[17]  C. Hanemann Magic but treatable? Tumours due to loss of merlin. , 2008, Brain : a journal of neurology.

[18]  D. Lallemand,et al.  Contact-dependent inhibition of EGFR signaling by Nf2/Merlin , 2007, The Journal of cell biology.

[19]  S. Tsukita,et al.  Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties , 2007, Genes to cells : devoted to molecular & cellular mechanisms.

[20]  M. Giovannini,et al.  Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. , 2007, Cancer research.

[21]  P. Herrlich,et al.  Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase , 2006, Nature.

[22]  Andrei Starostine,et al.  A Rich1/Amot Complex Regulates the Cdc42 GTPase and Apical-Polarity Proteins in Epithelial Cells , 2006, Cell.

[23]  R. Fehon,et al.  The Tumor Suppressors Merlin and Expanded Function Cooperatively to Modulate Receptor Endocytosis and Signaling , 2006, Current Biology.

[24]  J. Chernoff,et al.  Role of Group A p21-activated Kinases in Activation of Extracellular-regulated Kinase by Growth Factors* , 2005, Journal of Biological Chemistry.

[25]  F. Giancotti,et al.  Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane , 2005, The Journal of cell biology.

[26]  J. Miyoshi,et al.  Molecular perspective on tight-junction assembly and epithelial polarity. , 2005, Advanced drug delivery reviews.

[27]  S. Jhanwar,et al.  The NF2 Tumor Suppressor Gene Product, Merlin, Inhibits Cell Proliferation and Cell Cycle Progression by Repressing Cyclin D1 Expression , 2005, Molecular and Cellular Biology.

[28]  C. Haipek,et al.  Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression , 2004, Oncogene.

[29]  V. Ramesh Merlin and the ERM proteins in Schwann cells, neurons and growth cones , 2004, Nature Reviews Neuroscience.

[30]  Olli Carpén,et al.  Cyclic AMP-dependent Protein Kinase Phosphorylates Merlin at Serine 518 Independently of p21-activated Kinase and Promotes Merlin-Ezrin Heterodimerization* , 2004, Journal of Biological Chemistry.

[31]  J. Testa,et al.  A Clue to the Therapy of Neurofibromatosis Type 2: NF2/Merlin Is a PAK1 Inhibitor , 2004, Cancer journal.

[32]  Michael B Yaffe,et al.  Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. , 2003, Molecular cell.

[33]  K. Mielke,et al.  Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells. , 2003, Human molecular genetics.

[34]  M. Giovannini,et al.  NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. , 2003, Genes & development.

[35]  M. Umeda,et al.  Identification and functional characterization of nadrin variants, a novel family of GTPase activating protein for rho GTPases , 2002, Journal of neurochemistry.

[36]  M. Perricaudet,et al.  Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. , 2002, Genes & development.

[37]  T. Jacks,et al.  Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization* , 2002, The Journal of Biological Chemistry.

[38]  J. Testa,et al.  p21-activated Kinase Links Rac/Cdc42 Signaling to Merlin* , 2002, The Journal of Biological Chemistry.

[39]  P. Aspenström,et al.  RICH, a Rho GTPase-activating Protein Domain-containing Protein Involved in Signaling by Cdc42 and Rac1* , 2001, The Journal of Biological Chemistry.

[40]  T. Jacks,et al.  The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. , 2001, Developmental cell.

[41]  M. Umeda,et al.  Nadrin, a Novel Neuron-specific GTPase-activating Protein Involved in Regulated Exocytosis* , 2000, The Journal of Biological Chemistry.

[42]  A. Berns,et al.  Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. , 2000, Genes & development.

[43]  D. Cox,et al.  Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations. , 2000, American journal of human genetics.

[44]  G. Thomas,et al.  Conditional biallelic Nf 2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2 , 2000 .

[45]  M. Giovannini,et al.  Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of the NF2 gene , 1998, International journal of cancer.