Determination of N-acetylcysteine in pharmaceutical samples by flow injection

Two flow injection (FI) methods, involving spectrophotometric detection, are proposed for the determination of N-acetylcysteine (NAC). Both methods are based on the formation of a yellow complex between NAC and PdII in a medium of 1 mol dm–3 HCl. In the first method, which is based on the conventional Fl technique, NAC is determined over the range 5 × 10–5–5 × 10–3 mol dm–3, and in the second, in which the doublet-peak Fl mode is used, the working range is extended (5 × 10–5–5 × 10–2 mol dm–3). The Fl methods were applied to the determination of NAC in pharmaceutical samples.

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