The Transmission/Disequilibrium Test

The transmission-disequilibrium test (TDT) is an association-based test for linkage. It is a family-based test and thus avoids the problems potentially arising in case–control tests from population stratification. However it does this at some loss of power. Various other positive and negative features of the test are examined from a quantitative viewpoint. Keywords: transmission-disequilibrium test; linkage; association; power; marker alleles; chi-square tests

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