Characterization and engineering of the Lrp/AsnC family regulator SACE_5717 for erythromycin overproduction in Saccharopolyspora erythraea

[1]  Yansheng Wang,et al.  Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea , 2019, Journal of biological engineering.

[2]  Linhong Deng,et al.  SAV4189, a MarR-Family Regulator in Streptomyces avermitilis, Activates Avermectin Biosynthesis , 2018, Front. Microbiol..

[3]  B. Ye,et al.  PccD Regulates Branched-Chain Amino Acid Degradation and Exerts a Negative Effect on Erythromycin Production in Saccharopolyspora erythraea , 2018, Applied and Environmental Microbiology.

[4]  H. Rassi,et al.  Overproduction of Erythromycin by Ultraviolet Mutagenesis and Expression of ermE Gene in Saccharopolyspora erythraea. , 2017, Assay and drug development technologies.

[5]  J. Li,et al.  Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor , 2017, Applied Microbiology and Biotechnology.

[6]  E. Isogai,et al.  Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli. , 2017, Journal of bioscience and bioengineering.

[7]  E. Peeters,et al.  The genome-scale DNA-binding profile of BarR, a β-alanine responsive transcription factor in the archaeon Sulfolobus acidocaldarius , 2016, BMC Genomics.

[8]  Yuanyuan Pan,et al.  A Regulatory Gene SCO2140 is Involved in Antibiotic Production and Morphological Differentiation of Streptomyces coelicolor A3(2) , 2016, Current Microbiology.

[9]  M. Kinsella,et al.  Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach , 2016, Current Microbiology.

[10]  Yansheng Wang,et al.  Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea , 2016, Synthetic and systems biotechnology.

[11]  Milton H. Saier,et al.  The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis , 2015, PloS one.

[12]  Ying Wen,et al.  Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product , 2015, Applied and Environmental Microbiology.

[13]  Yawei Zhao,et al.  A stepwise increase in pristinamycin II biosynthesis by Streptomyces pristinaespiralis through combinatorial metabolic engineering. , 2015, Metabolic engineering.

[14]  Qing-ting Bu,et al.  Transcriptome-guided identification of SprA as a pleiotropic regulator in Streptomyces chattanoogensis , 2015, Applied Microbiology and Biotechnology.

[15]  B. Ye,et al.  Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea , 2014, Microbial Cell Factories.

[16]  B. Ye,et al.  Genetics and Molecular Biology of Industrial Organisms Sace_3986, a Tetr Family Transcriptional Regulator, Negatively Controls Erythromycin Biosynthesis in Saccharopolyspora Erythraea , 2022 .

[17]  L. Nielsen,et al.  Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach , 2013, BMC Genomics.

[18]  Gang Liu,et al.  Molecular Regulation of Antibiotic Biosynthesis in Streptomyces , 2013, Microbiology and Molecular Reviews.

[19]  N. Peixeiro,et al.  Cis-regulatory logic in archaeal transcription. , 2013, Biochemical Society transactions.

[20]  S. Muyldermans,et al.  Expanded target and cofactor repertoire for the transcriptional activator LysM from Sulfolobus , 2013, Nucleic acids research.

[21]  Z. Deng,et al.  Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008 , 2012, BMC Genomics.

[22]  Honghai Wang,et al.  Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors , 2011, Journal of cellular biochemistry.

[23]  Xunduan Huang,et al.  Identification of SACE_7040, a Member of TetR Family Related to the Morphological Differentiation of Saccharopolyspora erythraea , 2011, Current Microbiology.

[24]  D. Charlier,et al.  The Lrp Family of Transcription Regulators in Archaea , 2010, Archaea.

[25]  J. Martín,et al.  Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces. , 2010, Current opinion in microbiology.

[26]  J. Martín,et al.  PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis , 2009, Microbial cell factories.

[27]  C. Peano,et al.  Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production , 2009, Microbial cell factories.

[28]  D. Charlier,et al.  Ss‐LrpB, a transcriptional regulator from Sulfolobus solfataricus, regulates a gene cluster with a pyruvate ferredoxin oxidoreductase‐encoding operon and permease genes , 2009, Molecular microbiology.

[29]  C. Kao,et al.  A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea , 2008, Proceedings of the National Academy of Sciences.

[30]  Arkady B Khodursky,et al.  Limited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio , 2008, BMC Microbiology.

[31]  Y. Zhuang,et al.  Genetic Modulation of the Overexpression of Tailoring Genes eryK and eryG Leading to the Improvement of Erythromycin A Purity and Production in Saccharopolyspora erythraea Fermentation , 2008, Applied and Environmental Microbiology.

[32]  K. Yokoyama,et al.  Feast/famine regulation by transcription factor FL11 for the survival of the hyperthermophilic archaeon Pyrococcus OT3. , 2007, Structure.

[33]  L. Hellman,et al.  Electrophoretic mobility shift assay (EMSA) for detecting protein–nucleic acid interactions , 2007, Nature Protocols.

[34]  S. Lee,et al.  Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation , 2007, Proceedings of the National Academy of Sciences.

[35]  Markiyan Samborskyy,et al.  Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338 , 2007, Nature Biotechnology.

[36]  M. Merighi,et al.  Identification of the DNA bases of a DNase I footprint by the use of dye primer sequencing on an automated capillary DNA analysis instrument. , 2006, Journal of biomolecular techniques : JBT.

[37]  A. Demain,et al.  Genetic improvement of processes yielding microbial products. , 2006, FEMS microbiology reviews.

[38]  L. Ptitsyn,et al.  The yeaS (leuE) gene of Escherichia coli encodes an exporter of leucine, and the Lrp protein regulates its expression , 2005, FEBS letters.

[39]  N. P. Zakataeva,et al.  Expression of Genes Encoding the RhtB Family Proteins Depends on the Global Regulator Lrp , 2005, Molecular Biology.

[40]  M. Butler Natural products to drugs: natural product-derived compounds in clinical trials. , 2005, Natural product reports.

[41]  J. Westpheling,et al.  The bkdR Gene of Streptomyces coelicolor Is Required for Morphogenesis and Antibiotic Production and Encodes a Transcriptional Regulator of a Branched-Chain Amino Acid Dehydrogenase Complex , 2005, Journal of bacteriology.

[42]  V. Danilenko,et al.  Biogenesis and Regulation of Biosynthesis of Erythromycins in Saccharopolyspora erythraea , 2004, Applied Biochemistry and Microbiology.

[43]  C. Kao,et al.  Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. , 2004, Metabolic engineering.

[44]  Thijs J. G. Ettema,et al.  The Lrp family of transcriptional regulators , 2003, Molecular microbiology.

[45]  W. D. de Vos,et al.  The Sulfolobus solfataricus Lrp-like Protein LysM Regulates Lysine Biosynthesis in Response to Lysine Availability* , 2002, The Journal of Biological Chemistry.

[46]  Christine J. Martin,et al.  Increasing the efficiency of heterologous promoters in actinomycetes. , 2002, Journal of molecular microbiology and biotechnology.

[47]  M. Saier,et al.  The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators. , 1999, Journal of molecular microbiology and biotechnology.

[48]  F. Schneider,et al.  Relationship between valine, fatty acids, and spiramycin biosynthesis in Streptomyces ambofaciens. , 1994, Canadian journal of microbiology.

[49]  Hang Wu,et al.  Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea. , 2017, Metabolic engineering.

[50]  János Bérdy,et al.  Bioactive microbial metabolites. , 2005, The Journal of antibiotics.

[51]  C. Khosla,et al.  Process development and metabolic engineering for the overproduction of natural and unnatural polyketides. , 2001, Advances in biochemical engineering/biotechnology.