Zebrafish-based small molecule discovery.
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[1] Stuart L. Schreiber,et al. The small-molecule approach to biology , 2003 .
[2] M. Fishman,et al. From Zebrafish to human: modular medical models. , 2002, Annual review of genomics and human genetics.
[3] D. Nebert,et al. Transgenic Zebrafish as Sentinels for Aquatic Pollution , 2000, Annals of the New York Academy of Sciences.
[4] A. Rubinstein,et al. Zebrafish: from disease modeling to drug discovery. , 2003, Current opinion in drug discovery & development.
[5] Stuart L Schreiber,et al. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. , 2002, Journal of the American Chemical Society.
[6] Tae-Wook Kang,et al. Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening. , 2003, Journal of the American Chemical Society.
[7] Calum A. MacRae,et al. Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish , 2003, Circulation.
[8] L. Zon,et al. The art and design of genetic screens: zebrafish , 2001, Nature Reviews Genetics.
[9] V. Dzau,et al. Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development. , 2002, Biochemical and biophysical research communications.
[10] S. Schreiber,et al. Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays. , 2001, Journal of the American Chemical Society.
[11] J. Dowling,et al. Small molecule developmental screens reveal the logic and timing of vertebrate development. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[12] R. Myers,et al. Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays. , 2002, Genome research.
[13] A. Schier,et al. A genetic screen for mutations affecting embryogenesis in zebrafish. , 1996, Development.
[14] Wolfgang Driever,et al. gridlock, a localized heritable vascular patterning defect in the zebrafish , 1995, Nature Medicine.
[15] R. Plasterk,et al. Target-Selected Inactivation of the Zebrafish rag1 Gene , 2002, Science.
[16] R. King,et al. Chemistry or biology: which comes first after the genome is sequenced? , 1999, Chemistry & biology.
[17] P. Ingham,et al. Multiple Muscle Cell Identities Induced by Distinct Levels and Timing of Hedgehog Activity in the Zebrafish Embryo , 2003, Current Biology.
[18] M. Fishman,et al. FROM ZEBRAFISH TO HUMAN , 2002 .
[19] M. Fishman,et al. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul , 2001, Current Biology.
[20] R. Keeler. Teratogenic compounds of Veratrum californicum (Durand) X. Cyclopia in rabbits produced by cyclopamine. , 1970, Teratology.
[21] J. Law. Issues Related to the Use of Fish Models in Toxicologic Pathology: Session Introduction , 2003, Toxicologic pathology.
[22] Mark C. Fishman,et al. Zebrafish--the Canonical Vertebrate , 2001, Science.
[23] K. Anderson,et al. The transformation of the model organism: a decade of developmental genetics , 2003, Nature Genetics.
[24] Wiebke Herzog,et al. Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. , 2003, Molecular endocrinology.
[25] Tae-Wook Kang,et al. A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. , 2002, Journal of the American Chemical Society.
[26] M. Halpern,et al. Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters , 2001, Science.
[27] F. Kasten,et al. Paul Ehrlich: pathfinder in cell biology. 1. Chronicle of his life and accomplishments in immunology, cancer research, and chemotherapy. , 1996, Biotechnic & histochemistry : official publication of the Biological Stain Commission.
[28] Andrew P McMahon,et al. Developmental roles and clinical significance of hedgehog signaling. , 2003, Current topics in developmental biology.
[29] Stefan Hans,et al. Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish , 2003, Development.
[30] Jussi Taipale,et al. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. , 2002, Genes & development.
[31] Wilbert Bitter,et al. Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections , 2003, Cellular microbiology.
[32] James F Amatruda,et al. Zebrafish as a cancer model system. , 2002, Cancer cell.
[33] S. Ekker,et al. Effective targeted gene ‘knockdown’ in zebrafish , 2000, Nature Genetics.
[34] L. Ramakrishnan,et al. Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. , 2002, Immunity.
[35] R. Moon,et al. Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. , 2002, Development.
[36] U. Langheinrich,et al. Zebrafish: a new model on the pharmaceutical catwalk. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.
[37] Ki-Young Lee,et al. Cloned zebrafish by nuclear transfer from long-term-cultured cells , 2002, Nature Biotechnology.
[38] C. Mattingly,et al. Green fluorescent protein (GFP) as a marker of aryl hydrocarbon receptor (AhR) function in developing zebrafish (Danio rerio). , 2001, Environmental health perspectives.
[39] J. Eisen,et al. Headwaters of the zebrafish — emergence of a new model vertebrate , 2002, Nature Reviews Genetics.
[40] D A Kane,et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. , 1996, Development.
[41] S. Scheidt,et al. History of drugs for thrombotic disease. Discovery, development, and directions for the future. , 1994, Circulation.