Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophrenia
暂无分享,去创建一个
[1] A. Kathuria,et al. Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder , 2023, Discover Mental Health.
[2] A. Takata,et al. The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research , 2023, Molecular Psychiatry.
[3] Shi-Yan Ng,et al. Metabolic contributions to neuronal deficits caused by genomic disruption of schizophrenia risk gene SETD1A , 2022, Schizophrenia.
[4] Shani Stern,et al. Current progress in understanding schizophrenia using genomics and pluripotent stem cells: A meta-analytical overview , 2022, Schizophrenia Research.
[5] ChangHui Pak,et al. Probing the molecular and cellular pathological mechanisms of schizophrenia using human induced pluripotent stem cell models , 2022, Schizophrenia Research.
[6] S. Baron-Cohen,et al. Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity , 2022, Schizophrenia Research.
[7] Michael F. Green,et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia , 2022, Nature.
[8] S. Gabriel,et al. Rare coding variants in ten genes confer substantial risk for schizophrenia , 2022, Nature.
[9] J. Duan,et al. Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells , 2022, Schizophrenia Research.
[10] A. Vallée,et al. Neuroinflammation in Schizophrenia: The Key Role of the WNT/β-Catenin Pathway , 2022, International journal of molecular sciences.
[11] J. Tiihonen,et al. The iPSC perspective on schizophrenia , 2021, Trends in Neurosciences.
[12] D. Çolak,et al. The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors , 2021, Translational Psychiatry.
[13] S. Djurovic,et al. Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway , 2021, bioRxiv.
[14] D. O’Regan,et al. The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study , 2021, Translational Psychiatry.
[15] E. Zackai,et al. Association of Mitochondrial Biogenesis With Variable Penetrance of Schizophrenia. , 2021, JAMA psychiatry.
[16] D. Lewis,et al. Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex , 2020, Neuroscience.
[17] B. Mowry,et al. Neurexins in autism and schizophrenia—a review of patient mutations, mouse models and potential future directions , 2020, Molecular Psychiatry.
[18] Eric E. Bardes,et al. Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons , 2020, Proceedings of the National Academy of Sciences.
[19] Richard M. Lipkin,et al. Computational modeling of excitatory/inhibitory balance impairments in schizophrenia , 2020, Schizophrenia Research.
[20] B. Cohen,et al. Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia. , 2020, JAMA psychiatry.
[21] O. Howes,et al. Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats , 2020, Nature Communications.
[22] J. Réthelyi,et al. Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes , 2020, Stem cell research & therapy.
[23] B. Cohen,et al. Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine , 2019, Translational Psychiatry.
[24] A. Falk,et al. Stem cell models of schizophrenia, what have we learned and what is the potential? , 2019, Schizophrenia Research.
[25] R. Kahn,et al. Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies , 2019, Schizophrenia bulletin.
[26] F. Gage,et al. Modeling neuropsychiatric disorders using human induced pluripotent stem cells , 2019, Protein & Cell.
[27] Daniel R Weinberger,et al. Thinking About Schizophrenia in an Era of Genomic Medicine. , 2019, The American journal of psychiatry.
[28] Prashant S. Emani,et al. Comprehensive functional genomic resource and integrative model for the human brain , 2018, Science.
[29] M. Gerstein,et al. Transcriptome and epigenome landscape of human cortical development modeled in organoids , 2018, Science.
[30] D. Spengler,et al. Tracing Early Neurodevelopment in Schizophrenia with Induced Pluripotent Stem Cells , 2018, Cells.
[31] Emily E. Burke,et al. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs , 2018, bioRxiv.
[32] P. Penzes,et al. Dendritic structural plasticity and neuropsychiatric disease , 2018, Nature Reviews Neuroscience.
[33] I. Weiner,et al. Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder , 2018, Schizophrenia bulletin.
[34] G. Ming,et al. Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms , 2018, Genome Medicine.
[35] F. Gage,et al. Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward , 2018, Genome Medicine.
[36] D. Weinberger,et al. Genetic insights into the neurodevelopmental origins of schizophrenia , 2017, Nature Reviews Neuroscience.
[37] D. Weinberger. Future of Days Past: Neurodevelopment and Schizophrenia. , 2017, Schizophrenia bulletin.
[38] J. Coyle,et al. Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs). , 2017, Biochimica et biophysica acta. Molecular basis of disease.
[39] R. Roberts. Postmortem studies on mitochondria in schizophrenia , 2017, Schizophrenia Research.
[40] D. Ben-Shachar. Mitochondrial multifaceted dysfunction in schizophrenia; complex I as a possible pathological target , 2017, Schizophrenia Research.
[41] A. Sawa,et al. Clozapine as a Model for Antipsychotic Development , 2017, Neurotherapeutics.
[42] A. Sampson,et al. Selective Loss of Smaller Spines in Schizophrenia. , 2017, The American journal of psychiatry.
[43] Rakesh Karmacharya,et al. Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder. , 2017, Pharmacogenomics.
[44] K. Fish,et al. Developmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex , 2017, Proceedings of the National Academy of Sciences.
[45] M. Cuénod,et al. Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? , 2016, Schizophrenia Research.
[46] Rakesh Karmacharya,et al. Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells , 2016, Molecular and Cellular Neuroscience.
[47] S. Haggarty,et al. Stem cell models of neuropsychiatric disorders , 2016, Molecular and Cellular Neuroscience.
[48] Masahiko Watanabe,et al. Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins , 2016, Neuron.
[49] Fenna M. Krienen,et al. Transcriptional profiles of supragranular-enriched genes associate with corticocortical network architecture in the human brain , 2016, Proceedings of the National Academy of Sciences.
[50] P. Bonaldo,et al. Collagen VI at a glance , 2015, Journal of Cell Science.
[51] Marius Wernig,et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. , 2015, Cell stem cell.
[52] J. Coyle,et al. The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond. , 2015, Current opinion in pharmacology.
[53] Matthew E. Ritchie,et al. limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.
[54] J. Coyle,et al. Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder. , 2014, JAMA psychiatry.
[55] A. Koleske,et al. Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood , 2014, Front. Neuroanat..
[56] David W. Nauen,et al. Synaptic dysregulation in a human iPS cell model of mental disorders , 2014, Nature.
[57] A. Hayashi‐Takagi,et al. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence , 2014, Proceedings of the National Academy of Sciences.
[58] Friedemann Kiefer,et al. Modulation of synaptic function through the α-neurexin–specific ligand neurexophilin-1 , 2014, Proceedings of the National Academy of Sciences.
[59] Eric S. Lander,et al. A polygenic burden of rare disruptive mutations in schizophrenia , 2014, Nature.
[60] D. Lewis,et al. Dendritic spine pathology in schizophrenia , 2013, Neuroscience.
[61] A. Sawa,et al. Human Cell Models for Schizophrenia , 2013 .
[62] M. Missler,et al. Neurexins , 2013, Genome Biology.
[63] M. Furihata,et al. A mental retardation gene, motopsin/prss12, modulates cell morphology by interaction with seizure-related gene 6. , 2013, Biochemical and biophysical research communications.
[64] Thomas C. Südhof,et al. Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking , 2013, Cell.
[65] A. Sawa,et al. Synapse-specific contributions in the cortical pathology of schizophrenia , 2013, Neurobiology of Disease.
[66] Cole Trapnell,et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions , 2013, Genome Biology.
[67] D. Patel,et al. The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. , 2013, Genes & development.
[68] F. J. Livesey,et al. Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks , 2012, Nature Protocols.
[69] David R. Kelley,et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks , 2012, Nature Protocols.
[70] Peter Kirwan,et al. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses , 2012, Nature Neuroscience.
[71] A. Kriegstein,et al. Development and Evolution of the Human Neocortex , 2011, Cell.
[72] B. Cohen,et al. Behavioral effects of clozapine: Involvement of trace amine pathways in C. elegans and M. musculus , 2011, Brain Research.
[73] J. Rubenstein,et al. Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells , 2011, Neuron.
[74] Fred H. Gage,et al. Modelling schizophrenia using human induced pluripotent stem cells , 2011, Nature.
[75] M. Buchsbaum,et al. Correlations between ventricular enlargement and gray and white matter volumes of cortex, thalamus, striatum, and internal capsule in schizophrenia , 2011, European Archives of Psychiatry and Clinical Neuroscience.
[76] H. Eichenbaum,et al. Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology , 2011, Genes, brain, and behavior.
[77] A. Hayashi‐Takagi,et al. Disturbed synaptic connectivity in schizophrenia: Convergence of genetic risk factors during neurodevelopment , 2010, Brain Research Bulletin.
[78] C. Glass,et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.
[79] N. L. Le Novère,et al. Schizophrenic: forever young? , 2010, Genome Medicine.
[80] Christian Gaser,et al. Reduced cortical thickness in first episode schizophrenia , 2010, Schizophrenia Research.
[81] George Perry,et al. Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease , 2009, The Journal of Neuroscience.
[82] Satoshi O. Suzuki,et al. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice , 2009, Nature Cell Biology.
[83] D. Lewis,et al. Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies. , 2009, The Journal of clinical investigation.
[84] B. Cohen,et al. Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin Signaling Pathway in Caenorhabditis elegans , 2009, Neuropsychopharmacology.
[85] Claudia S. Barros,et al. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system , 2009, Proceedings of the National Academy of Sciences.
[86] L. DeLisi. Searching for the true genetic vulnerability for schizophrenia , 2009, Genome Medicine.
[87] M. Mattson,et al. Mitochondria in Neuroplasticity and Neurological Disorders , 2008, Neuron.
[88] S. Snyder,et al. Neuroscience: A complex in psychosis , 2008, Nature.
[89] A. Frigessi,et al. Regional thinning of the cerebral cortex in schizophrenia: Effects of diagnosis, age and antipsychotic medication , 2008, Schizophrenia Research.
[90] P. Arlotta,et al. Neuronal subtype specification in the cerebral cortex , 2007, Nature Reviews Neuroscience.
[91] Yasunori Hayashi,et al. The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses , 2004, Cell.
[92] Akira Sawa,et al. Schizophrenia: Diverse Approaches to a Complex Disease , 2002, Science.
[93] German Barrionuevo,et al. Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey prefrontal cortex , 2001, The Journal of comparative neurology.
[94] R. Hoffman,et al. Schizophrenia as a disorder of developmentally reduced synaptic connectivity. , 2000, Archives of general psychiatry.
[95] P. Goldman-Rakic,et al. Intrinsic circuit organization of the major layers and sublayers of the dorsolateral prefrontal cortex in the rhesus monkey , 1995, The Journal of comparative neurology.
[96] B. Pakkenberg,et al. Post-mortem Study of Chronic Schizophrenic Brains , 1987, British Journal of Psychiatry.
[97] D. Rossignol,et al. Mitochondrial Dysfunction in Psychiatric Disorders , 2015 .
[98] Hilde van der Togt,et al. Publisher's Note , 2003, J. Netw. Comput. Appl..
[99] Alex E. Lash,et al. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository , 2002, Nucleic Acids Res..
[100] B. Pakkenberg,et al. No deficit in total number of neurons in the prefrontal cortex in schizophrenics. , 2001, Journal of psychiatric research.
[101] D. Lewis,et al. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. , 2000, Archives of general psychiatry.
[102] I. Feinberg,et al. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? , 1982, Journal of psychiatric research.