I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection

[1]  P. Cohen,et al.  Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells* , 2012, The Journal of Biological Chemistry.

[2]  H. Chi,et al.  Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function , 2012, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Noula Shembade,et al.  The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1 , 2011, Nature Immunology.

[4]  B. Becher,et al.  NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses , 2011, The Journal of experimental medicine.

[5]  P. Cohen,et al.  Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β* , 2011, The Journal of Biological Chemistry.

[6]  M. Bajénoff,et al.  Visualizing Early Splenic Memory CD8+ T Cells Reactivation against Intracellular Bacteria in the Mouse , 2010, PloS one.

[7]  T. Kaisho,et al.  Cutting Edge: Critical Role of IκB Kinase α in TLR7/9-Induced Type I IFN Production by Conventional Dendritic Cells , 2010, The Journal of Immunology.

[8]  S. Akira,et al.  Pattern Recognition Receptors and Inflammation , 2010, Cell.

[9]  A. Iwasaki,et al.  Regulation of Adaptive Immunity by the Innate Immune System , 2010, Science.

[10]  B. Pulendran,et al.  Modulation of adaptive immunity with Toll-like receptors. , 2009, Seminars in immunology.

[11]  A. Hoffmann,et al.  A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling , 2009, Cell.

[12]  T. Taniguchi,et al.  Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes , 2009, PLoS pathogens.

[13]  J. Keats,et al.  Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling , 2008, Nature Immunology.

[14]  David A. Hume,et al.  Macrophages as APC and the Dendritic Cell Myth , 2008, The Journal of Immunology.

[15]  R. Steinman Dendritic cells in vivo: a key target for a new vaccine science. , 2008, Immunity.

[16]  S. Fischer,et al.  IKKalpha is required to maintain skin homeostasis and prevent skin cancer. , 2008, Cancer cell.

[17]  Marc Lecuit Human listeriosis and animal models. , 2007, Microbes and infection.

[18]  B. Reizis,et al.  Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen , 2007, The Journal of experimental medicine.

[19]  Qiang Sun,et al.  The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways , 2007, Nature Immunology.

[20]  B. Liu,et al.  Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 to Restrict Inflammation and Immunity , 2007, Cell.

[21]  Michael Karin,et al.  Regulation and Function of IKK and IKK-Related Kinases , 2006, Science's STKE.

[22]  K. Honda,et al.  IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors , 2006, Nature Reviews Immunology.

[23]  S. Akira,et al.  IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9 , 2006, Nature.

[24]  J. Hiscott,et al.  IRF-3 releases its inhibitions. , 2005, Structure.

[25]  Inder M. Verma,et al.  Enhanced NF-κB activation and cellular function in macrophages lacking IκB kinase 1 (IKK1) , 2005 .

[26]  Christophe Caux,et al.  A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells , 2005, The Journal of experimental medicine.

[27]  Toby Lawrence,et al.  IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation , 2005, Nature.

[28]  C. Sousa,et al.  Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function , 2005, Nature Immunology.

[29]  B. Aronow,et al.  Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers , 2004 .

[30]  E. Pamer Immune responses to Listeria monocytogenes , 2004, Nature Reviews Immunology.

[31]  M. Karin,et al.  The two NF-κB activation pathways and their role in innate and adaptive immunity , 2004 .

[32]  F. Inagaki,et al.  Identification of Ser-386 of Interferon Regulatory Factor 3 as Critical Target for Inducible Phosphorylation That Determines Activation* , 2004, Journal of Biological Chemistry.

[33]  Tak W. Mak,et al.  Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β , 2004 .

[34]  S. Akira,et al.  Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[35]  S. Akira,et al.  Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway , 2003, Science.

[36]  Guo-Ping Zhou,et al.  Triggering the Interferon Antiviral Response Through an IKK-Related Pathway , 2003, Science.

[37]  J. Ninomiya-Tsuji,et al.  A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase* , 2003, The Journal of Biological Chemistry.

[38]  M. Nierenstein,et al.  β‐Resorcylic Acid , 2003 .

[39]  M. Bevan,et al.  Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help , 2003, Science.

[40]  Steffen Jung,et al.  In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. , 2002, Immunity.

[41]  E. Schmidt,et al.  IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development , 2001, Cell.

[42]  S. Akira,et al.  Toll-like receptors control activation of adaptive immune responses , 2001, Nature Immunology.

[43]  Michael Karin,et al.  Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway , 2001, Science.

[44]  Zhijian J. Chen,et al.  TAK1 is a ubiquitin-dependent kinase of MKK and IKK , 2001, Nature.

[45]  D. Goeddel,et al.  Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice , 2001, Science.

[46]  A. Sher,et al.  CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. , 2000, Immunity.

[47]  T. Taniguchi,et al.  Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction , 2000 .

[48]  C. Hunter,et al.  The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii. , 1999, Journal of immunology.

[49]  T. Deerinck,et al.  The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis , 1999, The Journal of experimental medicine.

[50]  J. Hiscott,et al.  Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains , 1999, Molecular and Cellular Biology.

[51]  A. D'amico,et al.  RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells , 1998 .

[52]  J. Hiscott,et al.  Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation , 1998, Molecular and Cellular Biology.

[53]  C. Snapper,et al.  Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses , 1998, The Journal of experimental medicine.

[54]  Zhe‐Xi Luo,et al.  A new symmetrodont mammal from China and its implications for mammalian evolution , 1997, Nature.

[55]  E. Zandi,et al.  The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. , 1997, Cell.

[56]  E. Zandi,et al.  The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation , 1997, Cell.

[57]  D. Carrasco,et al.  Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2 , 1997, The Journal of experimental medicine.

[58]  STRUCTURAL AND FUNCTIONAL ANALYSIS , 2015 .

[59]  G. Cheng,et al.  NF-κB and innate immunity. , 2011, Current topics in microbiology and immunology.

[60]  S. Akira,et al.  Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7. , 2008, International immunology.

[61]  S. Akira,et al.  IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. , 2006, Nature.

[62]  I. Verma,et al.  Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[63]  Toby Lawrence,et al.  IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. , 2005, Nature.

[64]  M. Karin,et al.  The two NF-kappaB activation pathways and their role in innate and adaptive immunity. , 2004, Trends in immunology.

[65]  B. Aronow,et al.  Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. , 2004, The EMBO journal.

[66]  T. Mak,et al.  Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[67]  S. Akira,et al.  Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M. Karin,et al.  Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. , 2001, Science.

[69]  D. Goeddel,et al.  Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. , 2001, Science.

[70]  E. Schmidt,et al.  IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. , 2001, Cell.

[71]  T. Taniguchi,et al.  Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. , 2000, Immunity.

[72]  M. Karin,et al.  Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. , 2000, Annual review of immunology.

[73]  A. D'amico,et al.  RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. , 1998, Immunity.

[74]  L. Sokoloff,et al.  Animal models of rheumatoid arthritis. , 1984, International review of experimental pathology.