IMGT®, the international ImMunoGeneTics information system®

IMGT, the international ImMunoGeneTics information system (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM (Université Montpellier 2 and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. The building of a unique ontology, IMGT-ONTOLOGY, has made IMGT the global reference in immunogenetics and immunoinformatics. IMGT is a high-quality integrated knowledge resource specialized in the immunoglobulins or antibodies, T cell receptors, major histocompatibility complex, of human and other vertebrate species, proteins of the IgSF and MhcSF, and related proteins of the immune systems of any species. IMGT provides a common access to standardized data from genome, proteome, genetics and 3D structures. IMGT consists of five databases (IMGT/LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB, etc.), fifteen interactive online tools for sequence, genome and 3D structure analysis, and more than 10,000 HTML pages of synthesis and knowledge. IMGT is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas and myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow-up of residual diseases) and therapeutical approaches (graft, immunotherapy, vaccinology). IMGT is freely available at http://www.imgt.org.

[1]  Gérard Lefranc,et al.  The Immunoglobulin FactsBook , 2001 .

[2]  Marie-Paule Lefranc,et al.  IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data , 2004, Nucleic Acids Res..

[3]  Samson W. Tu,et al.  Protégé-2000: An Open-Source Ontology-Development and Knowledge-Acquisition Environment: AMIA 2003 Open Source Expo , 2003, AMIA.

[4]  Marie-Paule Lefranc,et al.  IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs , 2004, ISMB/ECCB.

[5]  Quentin Kaas,et al.  IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles? , 2008, Briefings in functional genomics & proteomics.

[6]  Marie-Paule Lefranc,et al.  IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics. , 2004, Molecular immunology.

[7]  Mathew W. Wright,et al.  Guidelines for human gene nomenclature. , 2002, Genomics.

[8]  Marie-Paule Lefranc,et al.  Immunogenetics Sequence Annotation: the Strategy of IMGT based on IMGT-ONTOLOGY , 2005, MIE.

[9]  Patrice Duroux,et al.  IMGT/LIGM-DB, the IMGT® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences , 2005, Nucleic Acids Res..

[10]  Marie-Paule Lefranc,et al.  IMGT-ONTOLOGY for immunogenetics and immunoinformatics , 2003, Silico Biol..

[11]  V. Giudicelli,et al.  IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains. , 2003, Developmental and comparative immunology.

[12]  M. Lefranc,et al.  Nomenclature of the Human Immunoglobulin Genes , 2000, Current protocols in immunology.

[13]  Marie-Paule Lefranc,et al.  IMGT-Choreography for immunogenetics and immunoinformatics , 2004, Silico Biol..

[14]  Rodrigo Lopez,et al.  Public web-based services from the European Bioinformatics Institute , 2004, Nucleic Acids Res..

[15]  Sue Povey,et al.  The HGNC Database in 2008: a resource for the human genome , 2007, Nucleic Acids Res..

[16]  Robert Sabatier,et al.  IMGT standardized criteria for statistical analysis of immunoglobulin V‐REGION amino acid properties , 2004, Journal of molecular recognition : JMR.

[17]  Marie-Paule Lefranc,et al.  Ontology for immunogenetics: the IMGT-ONTOLOGY , 1999, Bioinform..

[18]  Patrice Duroux,et al.  IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics , 2008, Briefings Bioinform..

[19]  T. N. Bhat,et al.  The Protein Data Bank , 2000, Nucleic Acids Res..

[20]  Marie-Paule Lefranc,et al.  IMGT, the international ImMunoGeneTics information system® , 2004, Nucleic Acids Res..

[21]  Evelyn Camon,et al.  The EMBL Nucleotide Sequence Database , 2004, Nucleic acids research.

[22]  Marie-Paule Lefranc,et al.  IMGT, the international ImMunoGeneTics database , 2001, Nucleic Acids Res..

[23]  Marie-Paule Lefranc,et al.  IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor VJ and VDJrearrangement analysis , 2004, Nucleic Acids Res..

[24]  Marie-Paule Lefranc,et al.  IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures , 2002, Immunogenetics.

[25]  Jérôme Lane,et al.  IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm. , 2008, Biochimie.

[26]  Olivier Elemento,et al.  IMGT/PhyloGene: an on-line tool for comparative analysis of immunoglobulin and T cell receptor genes. , 2003, Developmental and comparative immunology.

[27]  M. Lefranc,et al.  Nomenclature of the Human T Cell Receptor Genes , 2000, Current protocols in immunology.

[28]  Judith A. Blake,et al.  The Mouse Genome Database (MGD): mouse biology and model systems , 2007, Nucleic Acids Res..

[29]  M. Lefranc,et al.  Unique database numbering system for immunogenetic analysis. , 1997, Immunology today.

[30]  Marie-Paule Lefranc,et al.  WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report , 2007, Immunogenetics.

[31]  Matthew Sperrin,et al.  Multiple Testing Procedures with Applications to Genomics , 2010 .

[32]  Quentin Kaas,et al.  IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN. , 2005, Developmental and comparative immunology.

[33]  Marie-Paule Lefranc,et al.  IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis , 2008, Nucleic Acids Res..

[34]  Tatiana A. Tatusova,et al.  Entrez Gene: gene-centered information at NCBI , 2004, Nucleic Acids Res..

[35]  Hideaki Sugawara,et al.  DDBJ with new system and face , 2007, Nucleic Acids Res..

[36]  James Robinson,et al.  IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex , 2003, Nucleic Acids Res..

[37]  Suzanna E. Lewis,et al.  Sequence Ontology Annotation Guide , 2004, Comparative and functional genomics.

[38]  Marie-Paule Lefranc,et al.  IMGT, the international ImMunoGeneTics database. , 1997, Nucleic acids research.

[39]  James G. R. Gilbert,et al.  The vertebrate genome annotation (Vega) database , 2004, Nucleic Acids Res..

[40]  M. Lefranc,et al.  IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr , 2003, Leukemia.

[41]  Haruki Nakamura,et al.  Remediation of the protein data bank archive , 2007, Nucleic Acids Res..

[42]  Marie-Paule Lefranc,et al.  IMGT/GeneInfo: enhancing V(D)J recombination database accessibility , 2004, Nucleic Acids Res..

[43]  Mathieu Rouard,et al.  IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains. , 2005, Developmental and comparative immunology.

[44]  Marie-Paule Lefranc,et al.  MIMAS: an innovative tool for network-based high density oligonucleotide microarray data management and annotation , 2006, BMC Bioinformatics.

[45]  Dan Wu,et al.  Priorities for nucleotide trace, sequence and annotation data capture at the Ensembl Trace Archive and the EMBL Nucleotide Sequence Database , 2007, Nucleic Acids Res..

[46]  Marie-Paule Lefranc,et al.  IMGT , the international ImMunoGeneTics information system , 2003 .

[47]  David L. Wheeler,et al.  GenBank , 2015, Nucleic Acids Res..

[48]  Gérard Lefranc,et al.  The T cell receptor factsbook , 2001 .