AN AMYLOID LIGAND-FREE OPTICAL RETINAL IMAGING METHOD TO PREDICT CEREBRAL AMYLOID PET STATUS

Temporal-superior cross sections of AD cases occasionally showed small extracellular deposits (10-20 mm) with 6E10 and 12F4 antibodies in the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) (arrows), in addition to intracellular staining of ganglion cells and cells in the inner nuclear layer (asterisks). In controls intracellular staining with 6E10 and 12F4 is observed, rather than extracellular deposits. All scale bars 50 mm.