The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis.

[1]  F. Jardin,et al.  Two patterns of chromosomal breakpoint locations on the immunoglobulin heavy-chain locus in B-cell lymphomas with t(3;14)(q27;q32): relevance to histology , 2006, Oncogene.

[2]  P. Souček,et al.  Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma. , 2006, Cancer letters.

[3]  R. Gascoyne,et al.  Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study. , 2006, Blood.

[4]  P. Ferrigno,et al.  A peptide aptamer to antagonize BCL-6 function , 2006, Oncogene.

[5]  A. Melnick,et al.  Specific peptides for the therapeutic targeting of oncogenes. , 2006, Current opinion in genetics & development.

[6]  P. Lipsky,et al.  Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein , 2006, The Journal of experimental medicine.

[7]  K. Elenitoba-Johnson,et al.  Analysis of BCL6-interacting Proteins by Tandem Mass Spectrometry*S , 2005, Molecular & Cellular Proteomics.

[8]  L. Pasqualucci,et al.  Pathologic Co-Expression and Physical Interaction of c-MYC and BCL6 in B-Cell Lymphomas. , 2005 .

[9]  A. Melnick,et al.  BCL6 attenuates DNA damage sensing in normal and malignant B-cells by directly repressing ATR. , 2005 .

[10]  Theodore R Holford,et al.  A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma. , 2005, Journal of the National Cancer Institute.

[11]  E. Haralambieva,et al.  BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B , 2005, Genes, chromosomes & cancer.

[12]  O. Margalit,et al.  BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma. , 2005, Blood.

[13]  F. Jardin,et al.  Clinical and biological relevance of single-nucleotide polymorphisms and acquired somatic mutations of the BCL6 first intron in follicular lymphoma , 2005, Leukemia.

[14]  K. Basso,et al.  BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells , 2005, Nature Immunology.

[15]  Qiong Shen,et al.  Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. , 2005, Cancer cell.

[16]  F. Jardin,et al.  Targeted somatic mutation of the BCL6 proto-oncogene and its impact on lymphomagenesis. , 2005, Hematology.

[17]  Y. Natkunam,et al.  Expression of the bcl‐6 and MUM1/IRF4 proteins correlate with overall and disease‐specific survival in patients with primary cutaneous large B‐cell lymphoma: a tissue microarray study , 2005, Journal of cutaneous pathology.

[18]  A. Melnick.  Reprogramming Specific Gene Expression Pathways in B-Cell Lymphomas , 2005, Cell cycle.

[19]  Ryan T. Phan,et al.  The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells , 2004, Nature.

[20]  J. Licht,et al.  Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells , 2004, Nature Medicine.

[21]  D. Felsher,et al.  The human BCL6 transgene promotes the development of lymphomas in the mouse. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[22]  L. Staudt,et al.  Direct Repression of prdm1 by Bcl-6 Inhibits Plasmacytic Differentiation1 , 2004, The Journal of Immunology.

[23]  Ash A. Alizadeh,et al.  Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. , 2004, The New England journal of medicine.

[24]  J. Martinez-Climent,et al.  Bcl-6 mutation status provides clinically valuable information in early-stage B-cell chronic lymphocytic leukemia , 2004, Leukemia.

[25]  M. Lai,et al.  Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C. Schaller,et al.  Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation. , 2004, Blood.

[27]  Ramón Bosch,et al.  Building an outcome predictor model for diffuse large B-cell lymphoma. , 2004, The American journal of pathology.

[28]  A. Dent,et al.  Transcriptional repressor BCL-6 immortalizes germinal center-like B cells in the absence of p53 function , 2004, Oncogene.

[29]  Denis Bouchard,et al.  Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. , 2003, Molecular cell.

[30]  R. Siebert,et al.  Molecular Characterization of BCL6 Breakpoints in Primary Diffuse Large B‐cell Lymphomas of the Central Nervous System Identifies GAPD as Novel Translocation Partner , 2003, Brain pathology.

[31]  F. Jardin,et al.  Intronic BCL-6 mutations are preferentially targeted to the translocated allele in t(3;14)(q27;q32) non-Hodgkin B-cell lymphoma. , 2003, Blood.

[32]  L. Pasqualucci,et al.  Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma. , 2003, Blood.

[33]  Sunil Lakhani,et al.  BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation , 2003, Oncogene.

[34]  Takashi Akasaka,et al.  BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma. , 2003, Blood.

[35]  I. Lossos,et al.  The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene , 2003, Leukemia.

[36]  P. Casali,et al.  AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation. , 2003, Immunity.

[37]  Katia Basso,et al.  Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. , 2003, Blood.

[38]  Ash A. Alizadeh,et al.  Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations. , 2003, Blood.

[39]  R. Wall,et al.  Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a) , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Lisa M. Toney,et al.  Inhibition of Th2 Differentiation and GATA-3 Expression by BCL-6 1 , 2003, The Journal of Immunology.

[41]  N. Harris,et al.  BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[42]  O. Albagli-Curiel.  Ambivalent role of BCL6 in cell survival and transformation , 2003, Oncogene.

[43]  F. Jardin,et al.  Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics , 2002, Leukemia.

[44]  F. Jardin,et al.  Follicle center lymphoma is associated with significantly elevated levels of BCL-6 expression among lymphoma subtypes, independent of chromosome 3q27 rearrangements , 2002, Leukemia.

[45]  A. Naganuma,et al.  Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Wei Gu,et al.  Acetylation inactivates the transcriptional repressor BCL6 , 2002, Nature Genetics.

[47]  R. Warnke,et al.  BCL-6 mRNA expression in higher grade transformation of follicle center lymphoma: correlation with somatic mutations in the 5′ regulatory region of the BCL-6 gene , 2002, Leukemia.

[48]  Alberto Martin,et al.  Somatic hypermutation of the AID transgene in B and non-B cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[49]  Alexander L. Dent,et al.  Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene1 , 2002, The Journal of Immunology.

[50]  Chen-feng Qi,et al.  The Bcl6 locus is not mutated in mouse B-cell lineage lymphomas. , 2002, Leukemia research.

[51]  R. Gascoyne,et al.  Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma. , 2002, Cancer research.

[52]  M. Hatano,et al.  Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells , 2002, Nature Immunology.

[53]  Liming Yang,et al.  Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. , 2002, Immunity.

[54]  Jin-Hwang Liu,et al.  Low incidence of BCL‐6 gene alterations for diffuse large B‐cell lymphomas in Taiwan Chinese , 2002, Cancer.

[55]  S. Barrans,et al.  Rearrangement of the BCL6 locus at 3q27 is an independent poor prognostic factor in nodal diffuse large B‐cell lymphoma , 2002, British journal of haematology.

[56]  M. Piris,et al.  A short mutational hot spot in the first intron of BCL-6 is associated with increased BCL-6 expression and with longer overall survival in large B-cell lymphomas. , 2002, The American journal of pathology.

[57]  René Bernards,et al.  A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. , 2002, Genes & development.

[58]  Y. Furukawa,et al.  The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: Implications for a role of BCL6 in the down-regulation of apoptosis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[59]  G. Gaidano,et al.  Point mutations of the BCL-6 gene: clinical and prognostic correlation in B-diffuse large cell lymphoma , 2002, Leukemia.

[60]  H. Ohno,et al.  Non-immunoglobulin/ BCL6 Gene Fusion in Diffuse Large B-cell Lymphoma: Prognostic Implications , 2002, Leukemia & lymphoma.

[61]  R. Chaganti,et al.  Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma , 2001, Genes, chromosomes & cancer.

[62]  R Tibshirani,et al.  Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma. , 2001, Blood.

[63]  Gouri Nanjangud,et al.  Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas , 2001, Nature.

[64]  I. Lossos,et al.  A Polymorphism in the BCL-6 Gene is Associated with Follicle Center Lymphoma , 2001, Leukemia & lymphoma.

[65]  V. Diehl,et al.  Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction , 2000, The Journal of experimental medicine.

[66]  D. Fearon,et al.  Suppression of Signal Transducer and Activator of Transcription 3–Dependent B Lymphocyte Terminal Differentiation by Bcl-6 , 2000, The Journal of experimental medicine.

[67]  M. Schmid,et al.  Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF , 2000, Oncogene.

[68]  H. Ohno,et al.  Nonimmunoglobulin (non-Ig)/BCL6gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6 , 2000 .

[69]  L. Pasqualucci,et al.  BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia. , 2000, Cancer research.

[70]  N. Miyasaka,et al.  Identification of negative regulatory regions within the first exon and intron of the BCL6 gene , 2000, Oncogene.

[71]  L. Staudt,et al.  BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. , 2000, Immunity.

[72]  M. Dyer,et al.  The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. , 2000, Blood.

[73]  I. Lossos,et al.  Higher-grade transformation of follicle center lymphoma is associated with somatic mutation of the 5' noncoding regulatory region of the BCL-6 gene. , 2000, Blood.

[74]  P. Casali,et al.  B Cell Receptor Engagement and T Cell Contact Induce bcl-6 Somatic Hypermutation in Human B Cells: Identity with Ig Hypermutation1 , 2000, The Journal of Immunology.

[75]  H. Ohno,et al.  Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays. , 2000, Cancer research.

[76]  R. Warnke,et al.  Somatic mutation of the 5' noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma. , 2000, The American journal of pathology.

[77]  I. Lossos,et al.  Mutation analysis of the 5' noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity. , 2000, Blood.

[78]  Ash A. Alizadeh,et al.  Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling , 2000, Nature.

[79]  L. Pasqualucci,et al.  Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia. , 2000, Blood.

[80]  P. Pandolfi,et al.  Transcriptional Repression of Stat6-Dependent Interleukin-4-Induced Genes by BCL-6: Specific Regulation of Iɛ Transcription and Immunoglobulin E Switching , 1999, Molecular and Cellular Biology.

[81]  P. Isaacson,et al.  Nonimmunoglobulin gene hypermutation in germinal center B cells. , 1999, Blood.

[82]  D. Leprince,et al.  Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene , 1999, Oncogene.

[83]  J Hermans,et al.  Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. , 1998, Blood.

[84]  R. Evans,et al.  The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. , 1998, Nucleic acids research.

[85]  E. Cesarman,et al.  BCL-6 gene mutations in posttransplantation lymphoproliferative disorders predict response to therapy and clinical outcome. , 1998, Blood.

[86]  L. Pasqualucci,et al.  BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[87]  R. Dalla‐Favera,et al.  Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. , 1998, Genes & development.

[88]  M. Ebara,et al.  BAZF, a Novel Bcl6 Homolog, Functions as a Transcriptional Repressor , 1998, Molecular and Cellular Biology.

[89]  César Milstein,et al.  Monitoring and interpreting the intrinsic features of somatic hypermutation , 1998, Immunological reviews.

[90]  C. Chapman,et al.  Insight into the origin and clonal history of B‐cell tumors as revealed by analysis of immunoglobulin variable region genes , 1998, Immunological reviews.

[91]  Virginia Pascual,et al.  Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes , 1998, The Journal of experimental medicine.

[92]  S. Pileri,et al.  Detection of BCL‐6 rearrangements and p53 mutations in malt‐lymphomas , 1997, American journal of hematology.

[93]  F. Mandelli,et al.  Pathogenetic and clinical implications of Bcl‐6 and Bcl‐2 gene configuration in nodal diffuse large B‐cell lymphomas , 1997, The Journal of pathology.

[94]  D. Leprince,et al.  Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[95]  P. Pandolfi,et al.  The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation , 1997, Nature Genetics.

[96]  T. Akiyama,et al.  BCL-6 is phosphorylated at multiple sites in its serine- and proline-clustered region by mitogen-activated protein kinase (MAPK) in vivo , 1997, Oncogene.

[97]  L. Staudt,et al.  Control of inflammation, cytokine expression, and germinal center formation by BCL-6. , 1997, Science.

[98]  D. Leprince,et al.  Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation , 1997, Oncogene.

[99]  R S Chaganti,et al.  BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[100]  L. Staudt,et al.  Transcriptional repression by the proto-oncogene BCL-6. , 1996, Oncogene.

[101]  H. Ohno,et al.  Rearrangement of the BCL6 gene in B‐cell lymphoid neoplasms: comparison with lymphomas associated with BCL2 rearrangement , 1996, British journal of haematology.

[102]  K. Saito,et al.  Internal DNA deletion within the BCL-6 gene on untranslocated chromosome in non-Hodgkin's lymphoma with 3q27 abnormality. , 1996, Leukemia.

[103]  D. Leprince,et al.  The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo. , 1995, Oncogene.

[104]  K. Offit,et al.  Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[105]  R. Chaganti,et al.  Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. , 1995, The EMBO journal.

[106]  N. Kawamata,et al.  Biallelic DNA rearrangements and deletions within the BCL‐6 gene in B‐cell non‐Hodgkin's lymphoma , 1995, British journal of haematology.

[107]  R. Gascoyne,et al.  Frequent association of t(3;14) or variant with other lymphoma‐specific translocations , 1995, British journal of haematology.

[108]  N. Aoki,et al.  The organization of the BCL6 gene. , 1994, Leukemia.

[109]  M. Ladanyi,et al.  Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. , 1994, The New England journal of medicine.

[110]  A. Rossi,et al.  LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. , 1994, Blood.

[111]  H. Tilly,et al.  LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas , 1993, Nature Genetics.

[112]  P. H. Rao,et al.  Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. , 1993, Cancer research.

[113]  R. Espinosa,et al.  Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[114]  S. Pileri,et al.  Identification of outcome predictors in diffuse large B-cell lymphoma. Immunohistochemical profiling of homogeneously treated de novo tumors with nodal presentation on tissue micro-arrays. , 2005, Haematologica.

[115]  L. Staudt,et al.  Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. , 2004, Blood.

[116]  J. Nesland,et al.  Expression of bcl-6 and CD10 protein is associated with longer overall survival and time to treatment failure in follicular lymphoma. , 2004, American journal of clinical pathology.

[117]  Lisa M. Toney,et al.  Regulation of gene expression by the proto-oncogene BCL-6. , 2002, Critical reviews in oncology/hematology.

[118]  T. Honjo,et al.  Molecular mechanism of class switch recombination: linkage with somatic hypermutation. , 2002, Annual review of immunology.

[119]  J. Sierra,et al.  Bcl-6 p53 mutations in lymphomas carrying the bcl-2/Jh rearrangement. , 2002, Haematologica.

[120]  Z. Davis,et al.  Somatic mutation of bcl-6 genes can occur in the absence of V(H) mutations in chronic lymphocytic leukemia. , 2000, Blood.

[121]  U. Storb,et al.  Immunoglobulin transgenes as targets for somatic hypermutation. , 1998, The International journal of developmental biology.

[122]  G. Gaidano,et al.  Rearrangements of bcl-6, bcl-2, c-myc and 6q deletion in B-diffuse large-cell lymphoma: clinical relevance in 71 patients. , 1998, Annals of oncology : official journal of the European Society for Medical Oncology.

[123]  J. Banchereau,et al.  Induction of somatic mutation in a human B cell line in vitro. , 1997, Immunity.

[124]  N. Aoki,et al.  Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. , 1994, Blood.