Activation of the TCL1 protein in B cell lymphomas

The TCL1 gene, localized near the break point of chromosome 14q32.1 often involved in T cell leukemias, is also expressed in normal precursor T and B cells, and B cell lymphoma cell lines. We investigated the expression of the TCL1 protein in various types of B cell lymphomas according to the Revised European–American Classification of Lymphoid neoplasms. Paraffin‐embedded tissue sections of lymphoma specimens were subjected to TCL1 immunohistochemistry, and positivity was scored on a three‐tiered scale: – (< 25% cells), + (25–50% cells), and ++ (> 50% cells). The TCL1 protein was expressed in low‐grade B cell lymphomas including mucosa‐associated lymphoid tissue type in ocular adnexa (18/20, 90%). It was also expressed in follicular, lymphoplasmacytic, and mantle cell lymphoma, but not in high‐grade diffuse large B cell lymphoma (2/11, 18%). These data suggest that the expression of the TCL1 gene characterizes low‐grade B cell lymphomas, and may be involved in certain processes of lymphomatogenesis.

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