Human society needs still more intensive exploitation of all kinds of transportation facilities. This need lasts already several decades and is much more imperative in future. Mobility is one of most strict requirements for survival, besides the energy and food resources, health care and security. The requirements on transportation systems concern not only the quantitative and qualitative aspects of transportation activities, but still more also the aspects of their reliability and safety. This concerns not only the transported subjects or goods, but also the environment. In spite of the fact significant progress was made in recent years as concerns the transportation systems automation, the fully automatic transportation system in use is still for-seen in the considerably far future. Analyzing the reliability and safety of transportation, one finds that the activity of human being is the weakest point. The technical reliability of almost all the transportation tools has improved quite a lot in recent years, however the human subject interacting with them has not changed too much, as concerns his/her reliability and safety of the respective necessary interaction. Therefore, there is a hard necessity to improve it and the possibilities how to increase it stays still more in the focus of our interest. In this contribution, the overview of related problems is made, the challenges for further research and development in this area are discussed and the outline of the vision of with respect to human interaction reliability optimized transportation systems is presented.
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