THE EFFECT OF METHYLCHOLANTHRENE ON RAT PROSTATE GLANDS GROWN IN NATURAL AND SEMI-DEFINED MEDIUM.
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Summary The effects of 20-methylcholanthrene (MC) on organ cultures of ventral prostate glands from rats of different ages grown in natural and semi-defined medium were studied. In the natural medium MC induced extensive epithelial hyperplasia and partially inhibited the growth of the connective tissue within a short period of treatment. The hyperplastic epithelium consisted of undifferentiated and columnar cells without orientation, some of which were transformed into prickle cells. These were similar in explants derived from young and older animals. In explants treated for 10 days and transferred to control medium the hyperplasia was reduced, and the growth of the stroma resumed. In the semi-defined medium the effect of the carcinogen was much less marked and limited to an increase in cell size and formation of papillary projections.
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