Beta-lactam antibiotic offers neuroprotection in a spinal muscular atrophy model by multiple mechanisms
暂无分享,去创建一个
S. Salani | C. Donadoni | N. Bresolin | S. Corti | G. Riboldi | A. Govoni | F. Fortunato | M. Nizzardo | C. Simone | M. Nardini | D. Ronchi | G. Comi | G. Colciago | M. Falcone
[1] F. Sörgel,et al. Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections , 2010, Clinical Microbiology Reviews.
[2] C. Lorson,et al. Spinal muscular atrophy: mechanisms and therapeutic strategies. , 2010, Human molecular genetics.
[3] S. Jablonka,et al. Valproic acid blocks excitability in SMA type I mouse motor neurons , 2009, Neurobiology of Disease.
[4] H. Kornblum,et al. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro , 2009, Journal of neurochemistry.
[5] S. Salani,et al. Motoneuron Transplantation Rescues the Phenotype of SMARD1 (Spinal Muscular Atrophy with Respiratory Distress Type 1) , 2009, The Journal of Neuroscience.
[6] C. Beattie,et al. Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? , 2009, Nature Reviews Neuroscience.
[7] M. Bowerman,et al. SMN, profilin IIa and plastin 3: A link between the deregulation of actin dynamics and SMA pathogenesis , 2009, Molecular and Cellular Neuroscience.
[8] J L Haines,et al. Supporting Online Material Materials and Methods Figs. S1 to S7 Tables S1 to S4 References Mutations in the Fus/tls Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis , 2022 .
[9] Xun Hu,et al. Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6 , 2009, Science.
[10] C. Mello,et al. The Time to Demand Funding , 2009, Science.
[11] DelindaA . Johnson,et al. Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis , 2008, The Journal of Neuroscience.
[12] I-Fan Wang,et al. TDP-43 Overexpression Enhances Exon 7 Inclusion during the Survival of Motor Neuron Pre-mRNA Splicing* , 2008, Journal of Biological Chemistry.
[13] S. Salani,et al. Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy. , 2008, The Journal of clinical investigation.
[14] M. Winberg,et al. Identification of a battery of tests for drug candidate evaluation in the SMNΔ7 neonate model of spinal muscular atrophy , 2008, Experimental Neurology.
[15] Lili Wan,et al. SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing , 2008, Cell.
[16] P. Fisher,et al. Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes* , 2008, Journal of Biological Chemistry.
[17] B. Wirth,et al. Plastin 3 Is a Protective Modifier of Autosomal Recessive Spinal Muscular Atrophy , 2008, Science.
[18] L. Pellizzoni,et al. Ribonucleoprotein Assembly Defects Correlate with Spinal Muscular Atrophy Severity and Preferentially Affect a Subset of Spliceosomal snRNPs , 2007, PloS one.
[19] Jonathan D. Edwards,et al. Abnormal motor phenotype in the SMNΔ7 mouse model of spinal muscular atrophy , 2007, Neurobiology of Disease.
[20] A. MacKenzie,et al. Histologic and transcriptional assessment of a mild SMA model , 2007, Neurological research.
[21] K. Fischbeck,et al. Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. , 2007, The Journal of clinical investigation.
[22] H. Wichterle,et al. Multiprotein Complexes of the Survival of Motor Neuron Protein SMN with Gemins Traffic to Neuronal Processes and Growth Cones of Motor Neurons , 2006, The Journal of Neuroscience.
[23] Ming-Shiun Tsai,et al. Abolishing Bax-dependent apoptosis shows beneficial effects on spinal muscular atrophy model mice. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[24] B. Wirth,et al. Mildly affected patients with spinal muscular atrophy are partially protected by an increased SMN2 copy number , 2006, Human Genetics.
[25] J. Melki,et al. Activation of RNA metabolism-related genes in mouse but not human tissues deficient in SMN. , 2006, Physiological genomics.
[26] P. Vidal,et al. Regular Exercise Prolongs Survival in a Type 2 Spinal Muscular Atrophy Model Mouse , 2005, The Journal of Neuroscience.
[27] M. Baptista,et al. Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS. , 2005, Brain : a journal of neurology.
[28] J. Yong,et al. The Survival of Motor Neurons Protein Determines the Capacity for snRNP Assembly: Biochemical Deficiency in Spinal Muscular Atrophy , 2005, Molecular and Cellular Biology.
[29] K. Fischbeck,et al. The role of histone acetylation in SMN gene expression. , 2005, Human molecular genetics.
[30] U. Monani,et al. SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. , 2005, Human molecular genetics.
[31] P. Fisher,et al. β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression , 2005, Nature.
[32] U. Monani,et al. Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy. , 2004, The Journal of clinical investigation.
[33] M. Butchbach,et al. Perspectives on models of spinal muscular atrophy for drug discovery , 2004 .
[34] Jeongsik Yong,et al. Why do cells need an assembly machine for RNA-protein complexes? , 2004, Trends in cell biology.
[35] Michael Sendtner,et al. Smn, the spinal muscular atrophy–determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneurons , 2003, The Journal of cell biology.
[36] S. Iannaccone,et al. A phase 1 trial of riluzole in spinal muscular atrophy. , 2003, Archives of neurology.
[37] K. Fischbeck,et al. Valproic acid increases SMN levels in spinal muscular atrophy patient cells , 2003, Annals of neurology.
[38] Y. Hofmann,et al. Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy. , 2003, Human molecular genetics.
[39] W. Schlote,et al. Classical infantile spinal muscular atrophy with SMN deficiency causes sensory neuronopathy , 2003, Neurology.
[40] J. Yong,et al. Essential Role for the SMN Complex in the Specificity of snRNP Assembly , 2002, Science.
[41] N. M. Reddy,et al. Higher order arrangement of the eukaryotic nuclear bodies , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[42] U. Monani,et al. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. , 2000, Human molecular genetics.
[43] J. McPherson,et al. A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2. , 1999, Human molecular genetics.
[44] C. Lorson,et al. A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[45] J. Melki,et al. The role of the SMN gene in proximal spinal muscular atrophy. , 1998, Human molecular genetics.
[46] A. Smith,et al. Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[47] A. Burghes. When is a deletion not a deletion? When it is converted. , 1997, American journal of human genetics.
[48] J. Nadeau,et al. Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene. , 1997, Genome research.
[49] G. Vrbóva,et al. Possible strategies for treatment of SMA patients: A neurobiologist's view , 1995, Neuromuscular Disorders.
[50] J. Weissenbach,et al. Identification and characterization of a spinal muscular atrophy-determining gene , 1995, Cell.
[51] J. Rothstein,et al. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[52] A. Bretscher. Fimbrin is a cytoskeletal protein that crosslinks F-actin in vitro. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[53] D. F. Roberts,et al. The Genetic Component in Child Mortality , 1970, Archives of disease in childhood.
[54] L. Goodman,et al. THE PHARMACOLOGICAL BASIS OF THERAPEUTICS , 1966 .
[55] K. Foust,et al. Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes , 2009, Nature Biotechnology.
[56] S. Minucci,et al. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer , 2006, Nature Reviews Cancer.
[57] E. Bertini,et al. Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy , 2004, European Journal of Human Genetics.