Similarity Metrics for Groupwise Non-rigid Registration

The use of groupwise registration techniques for average atlas construction has been a growing area of research in recent years. One particularly challenging component of groupwise registration is finding scalable and effective groupwise similarity metrics; these do not always extend easily from pairwise metrics. This paper investigates possible choices of similarity metrics and additionally proposes a novel metric based on Normalised Mutual Information. The described groupwise metrics are quantitatively evaluated on simulated and 3D MR datasets, and their performance compared to equivalent pairwise registration.

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