A pH-Activatable Nanoprobe Labels Diverse Histologic Subtypes of Human Lung Cancer During Resection

[1]  Andrew D. Newton,et al.  Single-institution experience of 500 pulmonary resections guided by intraoperative molecular imaging. , 2023, The Journal of thoracic and cardiovascular surgery.

[2]  S. Singhal,et al.  Preclinical Evaluation of an Activity-Based Probe for Intraoperative Imaging of Esophageal Cancer , 2022, Molecular imaging.

[3]  Charles W. Bradley,et al.  A cathepsin targeted quenched activity-based probe facilitates enhanced detection of human tumors during resection. , 2022, Clinical cancer research : an official journal of the American Association for Cancer Research.

[4]  S. Singhal,et al.  Targeted detection of cancer cells during biopsy allows real-time diagnosis of pulmonary nodules , 2022, European Journal of Nuclear Medicine and Molecular Imaging.

[5]  S. Singhal,et al.  Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy , 2022, Nature Communications.

[6]  S. Singhal,et al.  Glycoprotein Receptor CEACAM5-Targeted Intraoperative Molecular Imaging Tracer in NSCLC. , 2022, The Annals of thoracic surgery.

[7]  S. Singhal,et al.  Impact of Intraoperative Molecular Imaging after Fluorescent-Guided Pulmonary Metastasectomy for Sarcoma. , 2022, Journal of the American College of Surgeons.

[8]  S. Singhal,et al.  A Prostate Specific Membrane Antigen-Targeted Near-Infrared Conjugate for Identifying Pulmonary Squamous Cell Carcinoma During Resection. , 2022, Molecular cancer therapeutics.

[9]  A. Jemal,et al.  Cancer statistics, 2022 , 2022, CA: a cancer journal for clinicians.

[10]  S. Singhal,et al.  3D Specimen Mapping Expedites Frozen Section Diagnosis of Non-Palpable Ground Glass Opacities. , 2021, The Annals of thoracic surgery.

[11]  S. Singhal,et al.  Targeted Intraoperative Molecular Imaging for Localizing Nonpalpable Tumors and Quantifying Resection Margin Distances. , 2021, JAMA surgery.

[12]  S. Bhatia,et al.  Microenvironment-triggered multimodal precision diagnostics , 2021, Nature Materials.

[13]  Jie Tian,et al.  Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings , 2021, Journal of biomedical optics.

[14]  S. Singhal,et al.  Intraoperative Detection and Assessment of Lung Nodules. , 2020, Surgical oncology clinics of North America.

[15]  K. Schepman,et al.  Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery , 2020, Nature Communications.

[16]  Pieterjan Debie,et al.  Latest developments in molecular tracers for fluorescence image-guided cancer surgery. , 2019, The Lancet. Oncology.

[17]  Samuel Achilefu,et al.  Perspective review of what is needed for molecular-specific fluorescence-guided surgery , 2018, Journal of biomedical optics.

[18]  Anne Wallace,et al.  Positive Surgical Margins in the 10 Most Common Solid Cancers , 2018, Scientific Reports.

[19]  Sunil Singhal,et al.  Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[20]  Andrew D. Newton,et al.  Intraoperative near-infrared imaging of mesothelioma. , 2017, Translational lung cancer research.

[21]  Shuming Nie,et al.  Near-Infrared Intraoperative Molecular Imaging Can Locate Metastases to the Lung. , 2017, The Annals of thoracic surgery.

[22]  Baran D. Sumer,et al.  A Transistor-like pH Nanoprobe for Tumour Detection and Image-guided Surgery , 2016, Nature Biomedical Engineering.

[23]  Andrew D. Newton,et al.  Intraoperative molecular imaging to identify lung adenocarcinomas. , 2016, Journal of thoracic disease.

[24]  S. Singhal,et al.  Clinical implications of positive margins following non‐small cell lung cancer surgery , 2016, Journal of surgical oncology.

[25]  Megan C. Garland,et al.  A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application. , 2016, Cell chemical biology.

[26]  Shuming Nie,et al.  The Optical Biopsy: A Novel Technique for Rapid Intraoperative Diagnosis of Primary Pulmonary Adenocarcinomas. , 2015, Annals of surgery.

[27]  P. Low,et al.  Intraoperative molecular imaging can identify lung adenocarcinomas during pulmonary resection. , 2015, The Journal of thoracic and cardiovascular surgery.

[28]  Jihyoun Jeon,et al.  Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010 , 2015, PloS one.

[29]  S. Singhal,et al.  Identification of a subcentimeter pulmonary adenocarcinoma using intraoperative near-infrared imaging during video-assisted thoracoscopic surgery. , 2015, The Journal of thoracic and cardiovascular surgery.

[30]  Shuming Nie,et al.  Intraoperative Near-Infrared Imaging Can Distinguish Cancer from Normal Tissue but Not Inflammation , 2014, PloS one.

[31]  Baran D. Sumer,et al.  A Broad Nanoparticle-Based Strategy for Tumor Imaging by Nonlinear Amplification of Microenvironment Signals , 2013, Nature materials.

[32]  Sunil Singhal,et al.  Local and Systemic Recurrence is the Achilles Heel of Cancer Surgery , 2011, Annals of Surgical Oncology.

[33]  R. Deberardinis,et al.  A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals , 2013 .