Mechanisms of Diastolic Dysfunction in Cardiovascular Disease Afterload-induced diastolic dysfunction contributes to high filling pressures in experimental heart failure with preserved ejection fraction

Sara Leite,* Sara Rodrigues,* Marta Tavares-Silva, José Oliveira-Pinto, Mohamed Alaa, Mahmoud Abdellatif, Dulce Fontoura, X Inês Falcão-Pires, Thierry C. Gillebert, Adelino F. Leite-Moreira, and X André P. Lourenço Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal; Cardiovascular Research Centre, Faculty of Medicine, University of Porto, Porto, Portugal; Department of Cardiology, Hospital São João, Porto, Portugal; Department of Vascular Surgery, Hospital São João, Porto, Portugal; Department of Cardiothoracic Surgery, Suez Canal University, Ismaileya, Egypt; Department of Cardiology, Ghent University, Ghent, Belgium; Department of Cardiothoracic Surgery, Hospital São João, Porto, Portugal; and Department of Anesthesiology, Hospital São João, Porto, Portugal

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