Vasoactive intestinal polypeptide receptor VPAC1 subtype is predominant in rat prostate membranes

The 28‐amino‐acid neuropeptide vasoactive intestinal peptide (VIP) might play an important role in the physiology of the prostate, since it stimulates glandular secretion, inhibits muscle contraction, stimulates proliferation of epithelial cells, and increases the secretion of prostate‐specific antigen (PSA). This neuropeptide may act through interaction with two types of high‐affinity receptors, named VPAC1 and VPAC2 receptors. Recently, selective agonists and antagonists for each receptor subtype were synthesized. We used them to identify the VIP receptor subclass expressed in rat prostatic tissue.

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