Effect of convulsions on cerebrospinal fluid and plasma activity of glutamic oxalacetic transaminase and lactic dehydrogenase

INCREASED CEREBROSPINAL FLUID glutamic oxalacetic transaminase (GOT) activity has been reported in dogs with experimental cerebral infarction,l and elevation of cerebrospinal fluid GOT and lactic dehydrogenase (LDH) activity has been observed in humans with cerebrovascular accidents and convulsions.= The blood-cerebrospinal fluid barrier7-10 normally prevents transfer of GOT from plasma to cerebrospinal fluid. We have found, however, that prolonged seizures in puppies increase the permeability of the blood-cerebrospinal fluid barrier as determined by the marked increase in the transfer of radioiodinated human serum albumin (RIHSA) from plasma to the cerebrospinal fluid.11 The purposes of this study were to evaluate (1) the effect of prolonged convulsions on the cerebrospinal fluid and plasma GOT and LDH activity in puppies and (2) whether the increased enzyme activity in the cerebrospinal fluid reflects changes in blood-cerebrospinal fluid barrier permeability.

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