Safety and Optimal Neuroprotection of neu2000 in acute Ischemic stroke with reCanalization: study protocol for a randomized, double-blinded, placebo-controlled, phase-II trial

[1]  Á. Chamorro,et al.  Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation , 2016, The Lancet Neurology.

[2]  A. Demchuk,et al.  Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials , 2016, The Lancet.

[3]  M. Fisher,et al.  Challenges and Opportunities of Endovascular Stroke Therapy , 2016, Annals of neurology.

[4]  C. Chung,et al.  Update of the Korean Clinical Practice Guidelines for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke , 2016, Journal of stroke.

[5]  Michael D Hill,et al.  Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke , 2015, The Lancet Neurology.

[6]  Eric E. Smith,et al.  Randomized assessment of rapid endovascular treatment of ischemic stroke. , 2015, The New England journal of medicine.

[7]  Hester F. Lingsma,et al.  A randomized trial of intraarterial treatment for acute ischemic stroke. , 2015, The New England journal of medicine.

[8]  Y. T. Wang,et al.  Excitotoxicity and stroke: Identifying novel targets for neuroprotection , 2014, Progress in Neurobiology.

[9]  Kiwon Lee,et al.  Therapeutic Hypothermia After Recanalization in Patients With Acute Ischemic Stroke , 2014, Stroke.

[10]  P. Sullivan,et al.  Antioxidant properties of Neu2000 on mitochondrial free radicals and oxidative damage. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.

[11]  B. Gwag,et al.  Iron mediates endothelial cell damage and blood-brain barrier opening in the hippocampus after transient forebrain ischemia in rats , 2011, Experimental & Molecular Medicine.

[12]  B. Gwag,et al.  Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat , 2011, Acta Neuropathologica.

[13]  B. Gwag,et al.  Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke. , 2010, Drug news & perspectives.

[14]  M. Ginsberg.  Current status of neuroprotection for cerebral ischemia: synoptic overview. , 2009, Stroke.

[15]  M. Kaste,et al.  Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. , 2008, The New England journal of medicine.

[16]  Y. Ahn,et al.  Marked Prevention of Ischemic Brain Injury by Neu2000, an NMDA Antagonist and Antioxidant Derived from Aspirin and Sulfasalazine , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  David J Gladstone,et al.  Toward Wisdom From Failure: Lessons From Neuroprotective Stroke Trials and New Therapeutic Directions , 2002, Stroke.

[18]  Karen Smith,et al.  Treatment of Comatose Survivors of Out-of-hospital Cardiac Arrest With Induced Hypothermia , 2003 .

[19]  S. Bernard,et al.  Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. , 2002, The New England journal of medicine.

[20]  Jin-Moo Lee,et al.  The changing landscape of ischaemic brain injury mechanisms , 1999, Nature.