Orchestrating Ca2+ influx through CaV1.2 and CaV3.x channels in human cerebral arteries

Vascular tone, and thus blood flow to a tissue bed, is regulated by neuronal-, endothelial-, and smooth muscle–dependent mechanisms. The smooth muscle–dependent component, reflecting the increase in arterial tone in response to increasing pressure (the myogenic response), has been appreciated

[1]  J. Patlak,et al.  Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations , 1996, The Journal of general physiology.

[2]  M. Nelson,et al.  TRPV4 Forms a Novel Ca2+ Signaling Complex With Ryanodine Receptors and BKCa Channels , 2005, Circulation research.

[3]  R. Tsien,et al.  Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967). , 1995, Molecular pharmacology.

[4]  W. Bayliss.  On the local reactions of the arterial wall to changes of internal pressure , 1902, The Journal of physiology.

[5]  L. Gray,et al.  T-type calcium channels blockers as new tools in cancer therapies , 2014, Pflügers Archiv - European Journal of Physiology.

[6]  E. Vigmond,et al.  CaV3.2 Channels and the Induction of Negative Feedback in Cerebral Arteries , 2014, Circulation research.

[7]  William A Catterall,et al.  Voltage-Gated Calcium Channels , 2011 .

[8]  M. Nelson,et al.  Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure , 1998, The Journal of physiology.

[9]  A. Zechariah,et al.  CaV1.2/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries , 2015, The Journal of general physiology.

[10]  E. Perez-Reyes.  Molecular physiology of low-voltage-activated t-type calcium channels. , 2003, Physiological reviews.

[11]  M. Rubart,et al.  Ca 2 + Currents in Cerebral Artery Smooth Muscle Cells of Rat at Physiological Ca 2 + Concentrations , 2003 .

[12]  M. Nelson,et al.  The role of T-type calcium channels in epilepsy and pain. , 2006, Current pharmaceutical design.