Scalar field model applied to the lamellar to the inverse hexagonal phase transition in lipid systems

Abstract In this paper we use a phenomenological field theory model to study the first-order phase transition from the lamellar phase to the inverse hexagonal phase in specific lipid bilayers. The model is described by a real scalar field with potential that supports both symmetric and asymmetric phase conformations. We adapt the coordinate and parameters of the model to describe the phase transition, and we show that the model is capable of correctly inferring the fraction of the inverse hexagonal phase in the phase transition, suggesting an alternative way to be couple to experimental techniques generally required for H I I − phase characterization.

[1]  L. Yaguzhinsky,et al.  Non-bilayer structures in mitochondrial membranes regulate ATP synthase activity. , 2018, Biochimica et biophysica acta. Biomembranes.

[2]  M. N. Tamashiro,et al.  Phase transitions in phospholipid monolayers: Statistical model at the pair approximation. , 2019, Physical review. E.

[3]  J. Boggs,et al.  Orientation and motion of amphiphilic spin labels in hexagonal lipid phases. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[4]  P. Cullis,et al.  Effects of fusogenic agent on membrane structure of erythrocyte ghosts and the mechanism of membrane fusion , 1978, Nature.

[5]  M. Kozlov,et al.  Bending, hydration and interstitial energies quantitatively account for the hexagonal-lamellar-hexagonal reentrant phase transition in dioleoylphosphatidylethanolamine. , 1994, Biophysical journal.

[6]  R. Epand,et al.  Oblique membrane insertion of viral fusion peptide probed by neutron diffraction. , 2000, Biochemistry.

[7]  D. Siegel Inverted micellar intermediates and the transitions between lamellar, cubic, and inverted hexagonal lipid phases. I. Mechanism of the L alpha----HII phase transitions. , 1986, Biophysical journal.

[8]  M. Caffrey Lipidat: A Database of Thermodynamic Data and Associated Information on Lipid Mesomorphic and Polymorphic Transitions , 1993 .

[9]  Frank Bringezu,et al.  Mechanism of the lamellar/inverse hexagonal phase transition examined by high resolution x-ray diffraction. , 2003, Biophysical journal.

[10]  G. Meer,et al.  Membrane lipids: where they are and how they behave , 2008, Nature Reviews Molecular Cell Biology.

[11]  A. Mark,et al.  Molecular view of hexagonal phase formation in phospholipid membranes. , 2004, Biophysical journal.

[12]  A. Tardieu,et al.  Lipid Phases: Structure and Structural Transitions , 1974 .

[13]  D. Siegel The modified stalk mechanism of lamellar/inverted phase transitions and its implications for membrane fusion. , 1999, Biophysical journal.

[14]  E. Pérez-Payá,et al.  Membrane-transferring regions of gp41 as targets for HIV-1 fusion inhibition and viral neutralization. , 2011, Current topics in medicinal chemistry.

[15]  F. Goñi,et al.  Effect of single chain lipids on phospholipase C-promoted vesicle fusion. A test for the stalk hypothesis of membrane fusion. , 1998, Biochemistry.

[16]  L. Chernomordik Non-bilayer lipids and biological fusion intermediates. , 1996, Chemistry and physics of lipids.

[17]  H. Grubmüller,et al.  Expansion of the fusion stalk and its implication for biological membrane fusion , 2014, Proceedings of the National Academy of Sciences.

[18]  R. Macdonald,et al.  Cubic phases in phosphatidylcholine-cholesterol mixtures: cholesterol as membrane "fusogen". , 2006, Biophysical journal.

[19]  S. Gruner,et al.  Membrane curvature, lipid segregation, and structural transitions for phospholipids under dual-solvent stress. , 1990, Biochemistry.

[20]  S. Tristram-Nagle,et al.  Structural insights into the cubic-hexagonal phase transition kinetics of monoolein modulated by sucrose solutions. , 2015, Physical chemistry chemical physics : PCCP.

[21]  R. Epand,et al.  The mechanism of lamellar-to-inverted hexagonal phase transitions in phosphatidylethanolamine: implications for membrane fusion mechanisms. , 1997, Biophysical journal.

[22]  A. Verkleij,et al.  Structural and Functional Aspects of Nonbilayer Lipids , 1982 .

[23]  J. Zimmerberg,et al.  Lipid polymorphisms and membrane shape. , 2011, Cold Spring Harbor perspectives in biology.

[24]  Kurt Binder,et al.  Theory of first-order phase transitions , 1987 .

[25]  H. Tsao,et al.  Hybrid membranes of lipids and diblock copolymers: From homogeneity to rafts to phase separation. , 2019, Physical review. E.

[26]  Tanmay Vachaspati,et al.  Kinks and Domain Walls: An Introduction to Classical and Quantum Solitons , 2006 .

[27]  Yongwei Zhang,et al.  High pressure effect on phase transition behavior of lipid bilayers. , 2012, Physical chemistry chemical physics : PCCP.

[28]  H. Delacroix,et al.  Inverse micellar phases of phospholipids and glycolipids. Invited Lecture , 2000 .

[29]  Kozlov Mm,et al.  On the Theory of Membrane Fusion. The Stalk Mechanism , 1984 .

[30]  H. Vogel,et al.  Induction of non-lamellar lipid phases by antimicrobial peptides: a potential link to mode of action. , 2010, Chemistry and physics of lipids.

[31]  D. Andelman,et al.  Budding transition of asymmetric two-component lipid domains. , 2016, Physical review. E.

[32]  B. Lentz,et al.  On the analysis of elastic deformations in hexagonal phases. , 2004, Biophysical journal.

[33]  Pressure-induced topological phase transitions in membranes. , 1992, Physical review letters.

[34]  A. Verkleij,et al.  Analysis of the hexagonal II phase and its relations to lipidic particles and the lamellar phase. A freeze-fracture study. , 1981, Biochimica et biophysica acta.