Rosemary polyphenols induce unfolded protein response and changes in cholesterol metabolism in colon cancer cells

[1]  L. Hendershot,et al.  The stressful road to antibody secretion , 2003, Nature Immunology.

[2]  Yutang Wang,et al.  Carnosic acid protects against ROS/RNS-induced protein damage and upregulates HO-1 expression in RAW264.7 macrophages , 2013 .

[3]  Antonio Segura-Carretero,et al.  Global Foodomics strategy to investigate the health benefits of dietary constituents. , 2012, Journal of chromatography. A.

[4]  C. Klaassen,et al.  Beneficial role of Nrf2 in regulating NADPH generation and consumption. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[5]  J. Nevins,et al.  The Rb/E2F pathway and cancer. , 2001, Human molecular genetics.

[6]  F. R. Papa,et al.  The UPR and cell fate at a glance , 2010, Journal of Cell Science.

[7]  J. Johnson Carnosol: a promising anti-cancer and anti-inflammatory agent. , 2011, Cancer letters.

[8]  Joseph L Goldstein,et al.  SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. , 2002, The Journal of clinical investigation.

[9]  C. Hetz,et al.  When ER stress reaches a dead end. , 2013, Biochimica et biophysica acta.

[10]  J. Cases,et al.  Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet , 2011, British Journal of Nutrition.

[11]  Alejandro Cifuentes,et al.  Comprehensive foodomics study on the mechanisms operating at various molecular levels in cancer cells in response to individual rosemary polyphenols. , 2014, Analytical chemistry.

[12]  C. Hetz The unfolded protein response: controlling cell fate decisions under ER stress and beyond , 2012, Nature Reviews Molecular Cell Biology.

[13]  Lingchong You,et al.  Network calisthenics , 2011, Cell cycle.

[14]  R. Tundis,et al.  NMR-based quantification of rosmarinic and carnosic acids, GC-MS profile and bioactivity relevant to neurodegenerative disorders of Rosmarinus officinalis L. extracts , 2013 .

[15]  E. Ibáñez,et al.  Present and future challenges in food analysis: foodomics. , 2012, Analytical chemistry.

[16]  E. Chevet,et al.  Redox controls UPR to control redox , 2014, Journal of Cell Science.

[17]  J. Johnson,et al.  Standardized rosemary (Rosmarinus officinalis) extract induces Nrf2/sestrin-2 pathway in colon cancer cells , 2015 .

[18]  Y. Takikawa,et al.  Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice , 2011, Hepatology research : the official journal of the Japan Society of Hepatology.

[19]  M. Madesh,et al.  Glutathione modulates lipid composition of human colon derived HT-29 cells. , 1998, The international journal of biochemistry & cell biology.

[20]  R. Kaufman,et al.  Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. , 2014, Antioxidants & redox signaling.

[21]  J. Hurst-Kennedy,et al.  Ubiquitin C-Terminal Hydrolase L1 in Tumorigenesis , 2012, Biochemistry research international.

[22]  D. Scheuner,et al.  Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. , 2005, Cell metabolism.

[23]  Songtao Li,et al.  Nuclear factor (erythroid‐derived 2)‐like 2 activation‐induced hepatic very‐low‐density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice , 2014, Hepatology.

[24]  Sana Basseri,et al.  Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential , 2011, Biochemistry research international.

[25]  Jiankun Cui,et al.  Carnosic acid, a catechol‐type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S‐alkylation of targeted cysteines on Keap1 , 2008, Journal of neurochemistry.

[26]  Hui-Hsuan Lin,et al.  Carnosic Acid, a Rosemary Phenolic Compound, Induces Apoptosis Through Reactive Oxygen Species-Mediated p38 Activation in Human Neuroblastoma IMR-32 Cells , 2011, Neurochemical Research.

[27]  A. Cifuentes,et al.  Effect of dietary polyphenols on K562 leukemia cells: A Foodomics approach , 2012, Electrophoresis.

[28]  A. Cifuentes,et al.  Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis , 2012, Genes & Nutrition.

[29]  R. Hamanaka,et al.  PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. , 2005, Molecular biology of the cell.

[30]  Kyoung-Jin Min,et al.  Carnosic Acid Induces Apoptosis Through Reactive Oxygen Species-mediated Endoplasmic Reticulum Stress Induction in Human Renal Carcinoma Caki Cells , 2014, Journal of cancer prevention.

[31]  Claudio R. Santos,et al.  Lipid metabolism in cancer , 2012, The FEBS journal.

[32]  G. Piwien-Pilipuk,et al.  Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. , 2013, Biochimica et biophysica acta.

[33]  L. Puricelli,et al.  Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells , 2012, Oncology reports.

[34]  L. Glimcher,et al.  The endoplasmic reticulum stress response in immunity and autoimmunity , 2008, Nature Reviews Immunology.

[35]  H. Abramson The lipogenesis pathway as a cancer target. , 2011, Journal of medicinal chemistry.

[36]  J. Johnson,et al.  Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer , 2013, Front. Pharmacol..

[37]  John Calvin Reed,et al.  ER stress-induced cell death mechanisms. , 2013, Biochimica et biophysica acta.

[38]  V. Carraro,et al.  The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression , 2013, Nucleic acids research.

[39]  J. Stevens,et al.  Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response , 2013, Toxicologic pathology.

[40]  A. Cifuentes,et al.  CE/LC‐MS multiplatform for broad metabolomic analysis of dietary polyphenols effect on colon cancer cells proliferation , 2012, Electrophoresis.

[41]  Melanie Korbelius,et al.  Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells[S] , 2014, Journal of Lipid Research.

[42]  E. Ibáñez,et al.  Two-step sequential supercritical fluid extracts from rosemary with enhanced anti-proliferative activity , 2014 .

[43]  G. Horgan,et al.  Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR , 2002 .

[44]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[45]  M. Katze,et al.  UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. , 2008, Developmental cell.