A new series of 1-(substituted)-2-({5-[(naphthalen-1/2-yloxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)ethanone 5 was synthesized by reacting 5-[(naphthalen-1/2-yloxy)methyl]-1,3,4-oxadiazole-2-thiol 4 with appropriate α-haloketones by multistep organic synthesis. The newly synthesized compounds were characterised by IR, 1H NMR, mass spectral data and elemental analysis. They were evaluated for antioxidant properties. Few of them exhibited promising activities.