Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

[1]  D. Holtzman,et al.  Clusterin contributes to caspase-3–independent brain injury following neonatal hypoxia-ischemia , 2001, Nature Medicine.

[2]  D. Sanan,et al.  Isolation and Characterization of Apolipoproteins from Murine Microglia , 2000, The Journal of Biological Chemistry.

[3]  A Rostagno,et al.  Apolipoprotein J (clusterin) and Alzheimer's disease , 2000, Microscopy research and technique.

[4]  S. Younkin,et al.  Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease , 2000 .

[5]  A Rostagno,et al.  Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. , 2000, The Biochemical journal.

[6]  A. Fagan,et al.  Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model , 2000, Annals of neurology.

[7]  D. Holtzman,et al.  Neuroinflammation and Alzheimer’s disease: critical roles for cytokine/Aβ-induced glial activation, NF-κB, and apolipoprotein E , 2000, Neurobiology of Aging.

[8]  A. Fagan,et al.  Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[9]  M. Wilson,et al.  Clusterin is a secreted mammalian chaperone. , 2000, Trends in biochemical sciences.

[10]  WARREN J. STRITTMATTER,et al.  Apolipoprotein E and Alzheimer's Disease , 2000, Annals of the New York Academy of Sciences.

[11]  S. Paul,et al.  Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[12]  A. Fagan,et al.  Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice* , 1999, The Journal of Biological Chemistry.

[13]  M. Mattson,et al.  Truncated Apolipoprotein E (ApoE) Causes Increased Intracellular Calcium and May Mediate ApoE Neurotoxicity , 1999, The Journal of Neuroscience.

[14]  B. Teter,et al.  Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures , 1999, Neuroscience.

[15]  Matthias Orth,et al.  Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/− Mice: Isoform-Specific Effects on Neurodegeneration , 1999, The Journal of Neuroscience.

[16]  A. Fagan,et al.  Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. , 1999, The Journal of clinical investigation.

[17]  M. Tabaton,et al.  Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[18]  L. V. Van Eldik,et al.  Apolipoprotein E Attenuates β‐Amyloid‐Induced Astrocyte Activation , 1998 .

[19]  T. Morgan,et al.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[20]  T. Morgan,et al.  Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease , 1998, The Journal of Neuroscience.

[21]  A. Fagan,et al.  Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins , 1998, The Journal of Neuroscience.

[22]  D. Holtzman,et al.  Nascent Astrocyte Particles Differ from Lipoproteins in CSF , 1998, Journal of neurochemistry.

[23]  R. Demattos,et al.  A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins* , 1998, The Journal of Biological Chemistry.

[24]  T. Wisniewski,et al.  Biology of Aβ Amyloid in Alzheimer's Disease , 1997, Neurobiology of Disease.

[25]  B. Permanne,et al.  Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants. , 1997, Biochemical and biophysical research communications.

[26]  S. Paul,et al.  Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition , 1997, Nature Genetics.

[27]  D. Michaelson,et al.  Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury , 1997, Neuroscience.

[28]  N. Maeda,et al.  Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis* , 1997, The Journal of Biological Chemistry.

[29]  D. Laskowitz,et al.  Apolipoprotein E suppresses glial cell secretion of TNFα , 1997, Journal of Neuroimmunology.

[30]  E. Masliah,et al.  Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE , 1997, Brain Research.

[31]  T. Morgan,et al.  Astrocytes and Microglia Respond to Estrogen with Increased apoE mRNAin Vivoandin Vitro , 1997, Experimental Neurology.

[32]  D. Selkoe,et al.  Alzheimer's Disease--Genotypes, Phenotype, and Treatments , 1997, Science.

[33]  R. Wetzel,et al.  Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E. , 1996, Biochemistry.

[34]  P. May,et al.  Clusterin (Apo J) Protects Against In Vitro Amyloid‐β(1–40) Neurotoxicity , 1996 .

[35]  Jonathan D. Smith,et al.  Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides , 1996, Nature Genetics.

[36]  M. Nakai,et al.  Expression of apolipoprotein E mRNA in rat microglia , 1996, Neuroscience Letters.

[37]  C. Soto,et al.  Apolipoprotein J and Alzheimer's amyloid beta solubility. , 1996, The Biochemical journal.

[38]  R. Gross,et al.  Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: electrospray ionization mass spectrometry-facilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-induced platelet phospholipid hydrolysis. , 1996, Biochemistry.

[39]  C. Wernstedt,et al.  Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain , 1995, Neuron.

[40]  G. Getz,et al.  Purification of Apolipoprotein E Attenuates Isoform-specific Binding to -Amyloid (*) , 1995, The Journal of Biological Chemistry.

[41]  E. Matsubara,et al.  Characterization of Apolipoprotein J-Alzheimer's Aβ Interaction (*) , 1995, The Journal of Biological Chemistry.

[42]  R. James,et al.  Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid. , 1995, Biochimica et biophysica acta.

[43]  T. Wisniewski,et al.  Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. , 1995, The Biochemical journal.

[44]  P. Lansbury,et al.  Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[45]  H. Brewer,et al.  Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments , 1994, Nature.

[46]  Xianlin Han,et al.  Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[47]  A. Roses,et al.  Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. , 1994, The Journal of clinical investigation.

[48]  R. Mahley,et al.  Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. , 1994, Science.

[49]  B. Hyman,et al.  Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.

[50]  S. Gauthier,et al.  Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats , 1993, Neuroscience.

[51]  T. Wisniewski,et al.  The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. , 1993, The Biochemical journal.

[52]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[53]  C. Finch,et al.  Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration , 1992, Trends in Neurosciences.

[54]  Thomas Wisniewski,et al.  Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid , 1992, Neuroscience Letters.

[55]  C. Finch,et al.  Sulfated glycoprotein-2 (SGP-2) mRNA is expressed in rat striatal astrocytes following ibotenic acid lesions , 1991, Neuroscience Letters.

[56]  S. Young,et al.  Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation. , 1991, The Journal of clinical investigation.

[57]  E. Otomo,et al.  Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease , 1991, Brain Research.

[58]  D. G. Ferguson,et al.  A 70-kDa apolipoprotein designated ApoJ is a marker for subclasses of human plasma high density lipoproteins. , 1990, The Journal of biological chemistry.

[59]  J. Heuser,et al.  Protocol for 3-D visualization of molecules on mica via the quick-freeze, deep-etch technique. , 1989, Journal of electron microscopy technique.

[60]  E. Krul,et al.  Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function. , 1988, Journal of lipid research.

[61]  T. Forte,et al.  Heterogeneity of nascent high density lipoproteins secreted by the hepatoma-derived cell line, Hep G2. , 1988, Journal of lipid research.

[62]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.

[63]  R. E. Pitas,et al.  Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. , 1987, The Journal of biological chemistry.

[64]  R. Mahley,et al.  Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. , 1987, Biochimica et biophysica acta.

[65]  M. Brown,et al.  A receptor-mediated pathway for cholesterol homeostasis. , 1986, Science.

[66]  J. Taylor,et al.  Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. , 1985, The Journal of clinical investigation.

[67]  I. Goldberg,et al.  Immunoaffinity isolation of apolipoprotein E-containing lipoproteins. , 1985, Biochimica et biophysica acta.

[68]  J. Heuser,et al.  Procedure for freeze-drying molecules adsorbed to mica flakes. , 1983, Journal of molecular biology.

[69]  G. Vega,et al.  Apolipoproteins in human cerebrospinal fluid. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[70]  R. Mahley,et al.  Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins. , 1978, Biochemistry.

[71]  C. Fielding,et al.  A protein cofactor of lecithin:cholesterol acyltransferase. , 1972, Biochemical and biophysical research communications.

[72]  R. Mahley,et al.  Lipoprotein-receptor interactions. , 1986, Methods in enzymology.