The power of tears: how tear proteomics research could revolutionize the clinic

A thin layer of tears covers the ocular surface. The tears are a complex fluid comprised of secretions from a number of sources including the lacrimal gland, goblet cells, cornea, and vascular sour...

[1]  R. Beuerman,et al.  Proteomic analysis revealed the altered tear protein profile in a rabbit model of Sjögren's syndrome‐associated dry eye , 2013, Proteomics.

[2]  Lei Zhou,et al.  Tear analysis in ocular surface diseases , 2012, Progress in Retinal and Eye Research.

[3]  J. Mehta,et al.  Comparison of corneal sensitivity, tear function and corneal staining following laser in situ keratomileusis with two femtosecond laser platforms , 2013, Clinical ophthalmology.

[4]  Lei Zhou,et al.  Characterization of the human tear metabolome by LC-MS/MS. , 2011, Journal of proteome research.

[5]  K. Nichols,et al.  iTRAQ quantitative proteomics in the analysis of tears in dry eye patients. , 2012, Investigative ophthalmology & visual science.

[6]  R. Beuerman,et al.  Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication. , 2011, Investigative ophthalmology & visual science.

[7]  A. Urbani,et al.  Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. , 2013, Molecular bioSystems.

[8]  T. Sobrino,et al.  Proteomic analysis of the tear film in patients with keratoconus , 2010, Molecular vision.

[9]  A. Palmigiano,et al.  Identification of human tear fluid biomarkers in vernal keratoconjunctivitis using iTRAQ quantitative proteomics , 2010, Allergy.

[10]  C. Kramann,et al.  Effect of contact lenses on the protein composition in tear film: a ProteinChip study , 2011, Graefe's Archive for Clinical and Experimental Ophthalmology.

[11]  N. Pfeiffer,et al.  Proteomics Differentiate Between Thyroid-Associated Orbitopathy and Dry Eye Syndrome. , 2015, Investigative ophthalmology & visual science.

[12]  Lei Zhou,et al.  In-depth analysis of the human tear proteome. , 2012, Journal of proteomics.

[13]  I. Butovich.  Tear film lipids. , 2013, Experimental eye research.

[14]  Angelika Unterhuber,et al.  In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography. , 2015, Optics express.

[15]  N. Packer,et al.  Glycomic characterization of basal tears and changes with diabetes and diabetic retinopathy. , 2015, Glycobiology.

[16]  Xiaoping Zhou,et al.  Quantitation of 47 human tear proteins using high resolution multiple reaction monitoring (HR-MRM) based-mass spectrometry. , 2015, Journal of proteomics.

[17]  Lei Zhou,et al.  Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. , 2009, Journal of proteome research.

[18]  Chan-Wha Kim,et al.  Comparison of tear proteins between healthy and early diabetic retinopathy patients. , 2012, Clinical biochemistry.

[19]  C. Lebrilla,et al.  Characterization of novel O-glycans isolated from tear and saliva of ocular rosacea patients. , 2013, Journal of proteome research.

[20]  E. Claude,et al.  Applications of ion-mobility mass spectrometry for lipid analysis , 2015, Analytical and Bioanalytical Chemistry.

[21]  R. Beuerman,et al.  Association of tear proteins with Meibomian gland disease and dry eye symptoms , 2010, British Journal of Ophthalmology.

[22]  N. Pfeiffer,et al.  Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients , 2016, Scientific Reports.

[23]  F. Liu,et al.  Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry. , 2014, Investigative ophthalmology & visual science.

[24]  J. Mehta,et al.  Comparative analysis of two femtosecond LASIK platforms using iTRAQ quantitative proteomics. , 2014, Investigative ophthalmology & visual science.

[25]  Min Li,et al.  Tear proteomic analysis of Sjögren syndrome patients with dry eye syndrome by two-dimensional-nano-liquid chromatography coupled with tandem mass spectrometry , 2014, Scientific Reports.

[26]  H. Kölbl,et al.  Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach , 2012, Oncology reports.

[27]  Miklós Emri,et al.  Changes in the Chemical Barrier Composition of Tears in Alzheimer’s Disease Reveal Potential Tear Diagnostic Biomarkers , 2016, PloS one.

[28]  Ruedi Aebersold,et al.  Using data‐independent, high‐resolution mass spectrometry in protein biomarker research: Perspectives and clinical applications , 2015, Proteomics. Clinical applications.

[29]  P. Padmanabhan,et al.  Tear Fluid Protein Changes in Dry Eye Syndrome Associated with Rheumatoid Arthritis: A Proteomic Approach. , 2017, The ocular surface.

[30]  Jen Hong Tan,et al.  Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction[S] , 2014, Journal of Lipid Research.